Ear infection
diseaseOn this page
Also known as otitis
Summary
Ear infection (MONDO:0021666) is a disease (an umbrella term covering 5 Mondo subtypes) and 30 clinical trials. Top therapeutic interventions include ciprofloxacin, dexmedetomidine, and montelukast. A subtype of infectious disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Umbrella term: 5 Mondo subtypes
- Clinical trials: 30
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | ear infection |
| Mondo ID | MONDO:0021666 |
| MeSH | D010031 |
| NCIT | C27193 |
| UMLS | C0699744 |
| MedGen | 147064 |
| Anatomy (UBERON) | UBERON:0001690 |
| Is cancer (heuristic) | no |
Also known as: Ear infection · otitis
Disease family
This is a subtype of infectious disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › ear infection
Related subtypes (34): infective endocarditis, hirudiniasis, fungal infectious disease, infectious peritonitis, epididymitis, viral infectious disease, bacterial infectious disease, parasitic infectious disease, abscess, Ciliophora infectious disease, hookworm infectious disease, infectious embryofetopathy, mycetoma, infectious disorder of the nervous system, sexually transmitted disease, puerperal infection, Acanthamoeba infectious disease, infectious myositis, infective vaginitis, skin disorder caused by infection, respiratory tract infectious disorder, nail infection, infective arthritis, digestive system infectious disorder, nosocomial infection, eye infectious disorder, prosthesis-related infectious disease, vector-borne disease, coinfection, urinary tract infection, hemorrhagic fever, protothecosis, pythiosis, infectious disease with sepsis
Subtypes (5): viral labyrinthitis, infectious otitis interna, otitis externa, geniculate herpes zoster, infectious otitis media
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 30.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 23 |
| PHASE4 | 3 |
| PHASE2 | 2 |
| PHASE3 | 1 |
| PHASE1/PHASE2 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00189462 | PHASE4 | COMPLETED | A Pilot Study to Evaluate the Efficacy of Montelukast in the Treatment of Acute Otitis Media (AOM) in Children |
| NCT00654329 | PHASE4 | COMPLETED | Dexmedetomidine vs Fentanyl for BMT |
| NCT00765635 | PHASE4 | COMPLETED | Chlorobutanol, Potassium Carbonate, and Irrigation in Cerumen Removal |
| NCT00967317 | PHASE3 | UNKNOWN | Phase III Open Study, Prospective, Multicenter, Randomized, Comparative to the Positive Control for Evaluating the Efficacy and Safety of Auris-Sedina in the Symptomatic Control of Otalgy in Patients With or Without Acute External Otitis. |
| NCT00872209 | PHASE1/PHASE2 | COMPLETED | Safety and Efficacy Study of Foam Otic Cipro Compared to a Standard Solution ( Ciloxan - Alcon Labs ) to Treat Acute Otitis Externa |
| NCT01157819 | PHASE2 | COMPLETED | Safety and Efficacy of Once-Daily Dosing of FoamOtic Cipro Compared to Twice-Daily Dosing of Ciloxan Ear Drops in Patients With Acute External Otitis |
| NCT01359098 | PHASE2 | COMPLETED | Efficacy and Safety of Once-Daily Ciprodexa Otic Foam Compared to Twice-daily Ciprodex Ear Drops in Acute Otitis Externa |
| NCT04471493 | Not specified | RECRUITING | Pediatric and Ambulatory Research in Infectious Diseases |
| NCT04743609 | Not specified | RECRUITING | RSV Burden in Outpatient and Hospital Settings |
| NCT05608993 | Not specified | ACTIVE_NOT_RECRUITING | RELAX: Reducing Length of Antibiotics for Children With Ear Infections |
| NCT05641285 | Not specified | ACTIVE_NOT_RECRUITING | Diagnostic Utility of Otosight Middle Ear Scope |
| NCT05741333 | Not specified | ACTIVE_NOT_RECRUITING | In-Office Clinical Study of the Solo+ TTD |
| NCT06023550 | Not specified | RECRUITING | Complicated Infections in Otorhinolaryngology |
| NCT06034080 | Not specified | RECRUITING | Interventions to De-implement Unnecessary Antibiotic Prescribing for Children With Ear Infections |
| NCT06429709 | Not specified | ACTIVE_NOT_RECRUITING | Utility of Advanced Ultrasound Otoscope In The Diagnosis of AOM |
| NCT07025473 | Not specified | NOT_YET_RECRUITING | Application of the Belle.AI Comparative Image Reference System for Describing Chronic Ear Infections in Pediatric Patients From Low-Resource Communities |
| NCT00694486 | Not specified | COMPLETED | Eustachian Tube Testing in a Pressure Chamber – Validation Study |
| NCT01033799 | Not specified | COMPLETED | Effect of the Consumption of a Fermented Milk on Common Infections in Shift-workers |
| NCT01315418 | Not specified | TERMINATED | Effect of the Consumption of a Fermented Milk on Common Infections in Adults Submitted to Multi-stressor Situation |
| NCT02610699 | Not specified | COMPLETED | Community Pediatric Acceptability Study (CPAS) |
| NCT02723890 | Not specified | COMPLETED | The Efficacy and Safety of Using the Novel Tyto Device |
| NCT02831985 | Not specified | COMPLETED | Postoperative Controls of Ventilation Tubes in Children - by General Practitioner or Otolaryngologist? |
| NCT03101605 | Not specified | COMPLETED | E-learning on the Trainees’ Ability to Diagnose and Treat Acute Otitis Media Among Children |
| NCT03398044 | Not specified | COMPLETED | Administration of Dexamethasone in PONV Prophylaxis in Children Undergoing Adenotomy |
| NCT03544138 | Not specified | COMPLETED | In-Office Study of the Hummingbird® in Children 6 Months-21 Years Old |
| NCT03722160 | Not specified | UNKNOWN | Clinical Study of the Solo Tympanostomy Tube Device |
| NCT04148417 | Not specified | UNKNOWN | Clinical Study of the Solo+ Tympanostomy Tube Device |
| NCT04296448 | Not specified | COMPLETED | Evaluation of Cellphone Based Otoscopy in Pediatric Patients |
| NCT04483232 | Not specified | UNKNOWN | Achromobacter Spp: Description of Epidemiology and Resistance in Chronic Ear Infections and in Healthy Individuals. |
| NCT06781164 | Not specified | COMPLETED | Examination of the Applicability and Performance of Otolaryngology Telemedicine, Telediagnostics in Establishing the Diagnosis and Therapy of Otolaryngology Diseases |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| CIPROFLOXACIN | 4 | 3 |
| DEXMEDETOMIDINE | 4 | 3 |
| MONTELUKAST | 4 | 3 |
| FENTANYL | 4 | 1 |
| SODIUM CHLORIDE | 4 | 1 |
| MEDETOMIDINE | 3 | 1 |
| CHEMBL5205127 | 0 | 1 |