Eastern equine encephalitis

Summary

Eastern equine encephalitis (MONDO:0005736) is a disease and 3 clinical trials. A subtype of viral encephalitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: <1 / 1 000 000 (United States) [Orphanet-validated]
• Clinical trials: 3

Clinical features

Epidemiology

Prevalence records

1 prevalence record(s), Orphanet:

Type	Class	Value	Geography	Validation
Annual incidence	<1 / 1 000 000	0.01	United States	Validated

Identifiers

Disease identifiers

Field	Value
Canonical name	eastern equine encephalitis
Mondo ID	MONDO:0005736
EFO	EFO:0007242
MeSH	D020242
Orphanet	83594
DOID	DOID:10841
ICD-10-CM	A83.2
ICD-11	682536148
UMLS	C0153065
MedGen	102258
GARD	0010821
MedDRA	10014587
Is cancer (heuristic)	no

Also known as: Eastern equine encephalomyelitis · Neuroinvasive Eastern equine encephalitis virus infection

Disease family

This is a subtype of viral encephalitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › nervous system disorder › central nervous system disorder › encephalomyelitis › encephalitis › infectious encephalitis › viral encephalitis › eastern equine encephalitis

Related subtypes (11): Powassan encephalitis, acute necrotizing encephalitis, acute hemorrhagic encephalitis, Colorado tick fever, subacute sclerosing panencephalitis, herpes simplex encephalitis, tick-borne encephalitis, encephalitis lethargica, mosquito-borne viral encephalitis, HHV-6 encephalitis, borna virus encephalitis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 3.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE2	2
PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00584805	PHASE2	COMPLETED	Safety and Immunogenicity Study of Eastern Equine Encephalitis (EEE) Vaccine
NCT02654509	PHASE2	COMPLETED	Safety and Immunogenicity Study of the Eastern Equine Encephalitis (EEE) Vaccine
NCT03879603	PHASE1	COMPLETED	VRC 313: A Trivalent Virus-like Particle (VLP) Encephalitis Vaccine (WEVEE) in Healthy Adults