Eclampsia
disease diseaseOn this page
Also known as eclampsia, postpartum
Summary
Eclampsia (MONDO:0001754) is a disease and 38 clinical trials. Top therapeutic interventions include acetaminophen, calcium, and ibuprofen. A subtype of toxemia of pregnancy — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 38
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | eclampsia |
| Mondo ID | MONDO:0001754 |
| MeSH | D004461 |
| DOID | DOID:13593 |
| ICD-10-CM | O15 |
| ICD-11 | 1759760659 |
| NCIT | C87167 |
| SNOMED CT | 303063000 |
| UMLS | C0013537 |
| MedGen | 4443 |
| Is cancer (heuristic) | no |
Also known as: eclampsia, postpartum
Disease family
This is a subtype of toxemia of pregnancy. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › cardiovascular disorder › vascular disorder › arterial disorder › hypertensive disorder › hypertension, pregnancy-induced › toxemia of pregnancy › eclampsia
Related subtypes (1): preeclampsia
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 38.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 30 |
| PHASE4 | 6 |
| PHASE3 | 2 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT06281665 | PHASE4 | RECRUITING | Treatment With Aspirin After Preeclampsia: TAP Trial |
| NCT07510568 | PHASE4 | NOT_YET_RECRUITING | Vitamin D Supplementation Among Pregnant Women in Uganda for the Prevention of Hypertensive Disorders in Pregnancy, and Other Adverse Maternal and Foetal Outcomes |
| NCT02911701 | PHASE4 | COMPLETED | Effect of Acetaminophen on Postpartum Blood Pressure Control in Preeclampsia With Severe Features |
| NCT02920593 | PHASE4 | UNKNOWN | A Randomized Control Trial of Vitamin D Prophylaxis in the Prevention of Hypertensive Disorders of Pregnancy |
| NCT06069102 | PHASE4 | COMPLETED | Optimal Blood Pressure Treatment Thresholds Postpartum |
| NCT06997575 | PHASE4 | COMPLETED | Comparing Intravenous and Intramuscular Magnesium Sulphate for Preventing Seizure Recurrence in Women With Eclampsia |
| NCT00000534 | PHASE3 | COMPLETED | Calcium for Pre-Eclampsia Prevention (CPEP) |
| NCT00097110 | PHASE3 | COMPLETED | RCT of Antioxidant Therapy to Prevent Preeclampsia in Brazil |
| NCT02578810 | Not specified | RECRUITING | PIERS and BIS, sFIT:PIGF, Adrenomedullin |
| NCT05655936 | Not specified | RECRUITING | Eliminating Severe Maternal Morbidity With Heart Health Doulas Trial |
| NCT05678062 | Not specified | RECRUITING | Point-of-care Ultrasound Abnormalities in Eclampsia |
| NCT06377878 | Not specified | RECRUITING | The Preeclampsia Registry |
| NCT06523569 | Not specified | RECRUITING | Mobile Health Interventions to Prevent Heart Disease After Hypertensive Disorders of Pregnancy |
| NCT07151339 | Not specified | RECRUITING | Pilot Project Renal and Cardiovascular Tertiary Prevention in Preeclampsia |
| NCT00005456 | Not specified | COMPLETED | Hypertensive and Normal Pregnancy–Calcium Metabolism and Renin-Angiotensin - SCOR in Hypertension |
| NCT00215969 | Not specified | UNKNOWN | Prospective Study in Pregnant Women With Hypercoagulopathy |
| NCT01736826 | Not specified | COMPLETED | Free DNA and Nucleosome Concentrations in Pathological Pregnancies |
| NCT01751945 | Not specified | COMPLETED | Improved Accessibility of EmONC Services for Maternal and Newborn Health: a Community Based Project |
| NCT01856387 | Not specified | UNKNOWN | The Effect of neutrophil-to Lymphocyte Ratio in Preeclampsia- Eclampsia |
| NCT01990625 | Not specified | COMPLETED | A Cluster-Randomized Trial of Ultrasound Use to Improve Pregnancy Outcomes in Low Income Country Settings |
| NCT02027272 | Not specified | TERMINATED | Eclampsia and Posterior Reversible Encephalopathy Syndrome (PRES): |
| NCT02256995 | Not specified | UNKNOWN | uChek Pilot Study for Urinalysis in the Antenatal Care Setting |
| NCT02351583 | Not specified | WITHDRAWN | Microcirculatory and Tissue and Cerebral Oxygenation in Preeclampsia and Normal Pregnancy: An Observation Study |
| NCT02468310 | Not specified | COMPLETED | Evaluating the Effects of SMS Text Messaging Support System Among Frontline Health Workers in Ghana |
| NCT02765906 | Not specified | COMPLETED | Comparing Different Methods of Patient Education on Preeclampsia |
| NCT02797353 | Not specified | COMPLETED | Strengthening Maternal Neonatal and Child Health Services in a Rural District of Pakistan |
| NCT03028194 | Not specified | COMPLETED | Postpartum Uterine Curettage in the Recovery From Preeclampsia/Eclampsia |
| NCT03200743 | Not specified | UNKNOWN | Catestatin and Hypertension in Pregnancy |
| NCT03455387 | Not specified | COMPLETED | Evaluation of the Serum Markers sFLt1 and PlGF for the Prediction of the Complications of the Placental Vascular Pathologies in the 3rd Quarter of the Pregnancy. |
| NCT03978429 | Not specified | COMPLETED | An mHealth Strategy to Reduce Pre-Eclampsia and Infant Death in Tanzania |
| NCT04160923 | Not specified | COMPLETED | Incidence and Neonatal Outcome of Eclamptic Parturient in Tertiary Hospital. |
| NCT04468763 | Not specified | UNKNOWN | Cardiac Biomarkers in Preeclampsia: Prediction of Disease and the Risk of Future Cardiovascular Events in Survivors |
| NCT04855513 | Not specified | UNKNOWN | Prevention of Pre-eclampsia Using Metformin: a Randomized Control Trial |
| NCT04998942 | Not specified | UNKNOWN | Virtual Cardiac Wellness Program Following Hypertensive Disorders of Pregnancy |
| NCT05121415 | Not specified | COMPLETED | Investigation of Genetic Disease Marker Associated With Spontaneous Haemorrhagic Stroke Complicating Severe Pre-eclampsia in Pregnancy |
| NCT05143710 | Not specified | COMPLETED | The Clinical and Prognostic Features of PRES |
| NCT06126068 | Not specified | COMPLETED | Comparison of Loading Dose Magnesium Sulphate With Prichard Regimen in the Management of Severe Preeclampsia and Eclampsia. |
| NCT06219109 | Not specified | UNKNOWN | Pulmonary Edema Resolution in Severe Preeclampsia and Eclampsia |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| ACETAMINOPHEN | 4 | 1 |
| CALCIUM | 4 | 1 |
| IBUPROFEN | 4 | 1 |
| CHEMBL5072826 | 0 | 1 |
Related Atlas pages
- Drugs: Acetaminophen, Calcium, Ibuprofen