Ectopic pregnancy
diseaseOn this page
Also known as extrauterine pregnancypregnancy, ectopic
Summary
Ectopic pregnancy (MONDO:0000755) is a disease and 63 clinical trials. Top therapeutic interventions include methotrexate, cetrorelix, and letrozole. A subtype of female reproductive system disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 63
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | ectopic pregnancy |
| Mondo ID | MONDO:0000755 |
| MeSH | D011271 |
| DOID | DOID:0060329 |
| ICD-11 | 1563334645 |
| NCIT | C34945 |
| SNOMED CT | 34801009 |
| UMLS | C0032987 |
| MedGen | 18618 |
| Is cancer (heuristic) | no |
Also known as: extrauterine pregnancy · pregnancy, ectopic
Disease family
This is a subtype of female reproductive system disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › reproductive system disorder › female reproductive system disorder › ectopic pregnancy
Related subtypes (33): pelvic inflammatory disease, endosalpingiosis, vaginal disorder, prolapse of female genital organ, Allen-Masters syndrome, fallopian tube disorder, vulvar disease, uterine disorder, gynatresia, Bartholin duct cyst, ovarian disorder, hymen, imperforate, preterm premature rupture of the membranes, mammary-digital-nail syndrome, Asherman syndrome, uterine cervical aplasia and agenesis, longitudinal vaginal septum, transverse vaginal septum, polycystic ovaries-urethral sphincter dysfunction syndrome, granulomatous mastitis, vaginal atresia, mullerian aplasia, vulvovaginal gingival syndrome, isolated partial vaginal agenesis, female infertility, female reproductive system neoplasm, polyp of vulva, vulval varices, vulvodynia, menstrual cycle-dependent periodic fever, Bartholin’s gland disease, delayed puberty, self-limited, menstrual disorder
Subtypes (4): abdominal ectopic pregnancy, tubal pregnancy, ovarian ectopic pregnancy, pregnancy, cornual
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
Drugs indicated for this disease
0 approved, 1 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.
| Drug | Development status |
|---|---|
| Methotrexate | Phase 3 (in late-stage trials) |
Clinical trials & evidence
Clinical trials
Clinical trials: 63.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 51 |
| PHASE4 | 5 |
| PHASE3 | 3 |
| PHASE1/PHASE2 | 3 |
| EARLY_PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT06354439 | PHASE4 | RECRUITING | Use of Letrozole for Ectopic Pregnancy |
| NCT01662167 | PHASE4 | COMPLETED | Comparison of Single and Multiple-dose Methotrexate Therapy for Ectopic Pregnancy |
| NCT01860690 | PHASE4 | UNKNOWN | BHCG Level in Day 4,7, in Comparison to Day 10 as an Indicator for Treatment Success |
| NCT01876004 | PHASE4 | COMPLETED | Effectiveness Of Expectant Management In The Tubal Ectopic Pregnancy |
| NCT05198141 | PHASE4 | COMPLETED | Evaluation of Different Doses of Letrozole in Ectopic Pregnancy |
| NCT00194272 | PHASE3 | COMPLETED | Two-Dose Methotrexate for Ectopic Pregnancy |
| NCT01855568 | PHASE3 | COMPLETED | Methotrexate Treatment for Ectopic Pregnancy |
| NCT02152696 | PHASE3 | COMPLETED | Optimal Treatment for Women With a Persisting Pregnancy of Unknown Location |
| NCT01800162 | PHASE1/PHASE2 | TERMINATED | RCT for Women With a Persisting Pregnancy of Unknown Location |
| NCT04071574 | PHASE1/PHASE2 | COMPLETED | Comparative Study on the Efficacy of Ovarian Stimulation Protocols on the Success Rate of ICSI in Female Infertility |
| NCT05918718 | PHASE1/PHASE2 | UNKNOWN | Assessment of the Efficacy of Letrozole in the Treatment of Ectopic Pregnancy |
| NCT06559280 | EARLY_PHASE1 | COMPLETED | The Effect of Subclinical Dose of Ketamine on Early Postoperative Pain Sensitivity in Patients Undergoing Salpingectomy |
| NCT06471166 | Not specified | RECRUITING | The Effect of Different Treatment Modalities of Tubal Ectopic Pregnancy on Ovarian Reserve: a Prospective Cohort Study |
| NCT06486415 | Not specified | NOT_YET_RECRUITING | Novel Diagnosis of Ectopic Pregnancy |
| NCT06554964 | Not specified | NOT_YET_RECRUITING | Chromotubation on the Remaining Fallopian Tube After a Laparoscopic Salpingectomy Due to Tubal Pregnancy |
| NCT06615843 | Not specified | RECRUITING | Randomized Study of a Dematerialized Management for Post-Emergency Gynecological Follow-Up |
| NCT06721403 | Not specified | NOT_YET_RECRUITING | Psychatric Effect of Ectopic Pregnancy |
| NCT07009808 | Not specified | NOT_YET_RECRUITING | Nalbuphine Dosing and Its Impact on Anxiety and Depression in Ectopic Pregnancy Surgery |
| NCT07057115 | Not specified | RECRUITING | Comparison of vNOTES and Laparoscopic Salpingectomy in the Surgical Treatment of Ectopic Pregnancy |
| NCT07186127 | Not specified | RECRUITING | Methotrexate Treatment in Cases of Ectopic Pregnancy With Relative Contraindications |
| NCT07306689 | Not specified | RECRUITING | Posttraumatic Stress Disorder in Ectopic Pregnancy |
| NCT07431411 | Not specified | NOT_YET_RECRUITING | Reproductive Health Education, Birth Control and Sexual Quality of Life in Ectopic Pregnancy |
| NCT07541937 | Not specified | RECRUITING | Doppler Flow in Tubal Ectopic Pregnancy in Diagnosis as a Predictor of Treatment Success - Conservative and MTX Treatment |
| NCT00194168 | Not specified | COMPLETED | Ectopic Pregnancy Biomarkers |
| NCT00194207 | Not specified | COMPLETED | Risk Factors of Ectopic Pregnancy |
| NCT00683202 | Not specified | COMPLETED | Low-Dose Aspirin in in Vitro Fertilization (IVF) and Intracytoplasmic Sperm Injection (ICSI) Treatments |
| NCT00827970 | Not specified | COMPLETED | Randomized Population-Based Study on Chlamydia Trachomatis Screening |
| NCT01261026 | Not specified | COMPLETED | Are Serum Levels of Vascular Endothelial Growth Factor a Marker for the Early Diagnosis of Ectopic Pregnancy? |
| NCT01322958 | Not specified | COMPLETED | Sonographic Assessment and Visualization of Ectopics in Emergency Medicine |
| NCT01589016 | Not specified | COMPLETED | Activin A and Inhibin A in Predicting Outcome of Pregnancies of Unknown Location After Assisted Reproductive Technology |
| NCT02700789 | Not specified | COMPLETED | Pregnancies of Uncertain Location or Viability Research |
| NCT02714998 | Not specified | COMPLETED | The Impact of Salpingectomy and Single Dose Systemic Methotrexate Treatments on Ovarian Reserve in Ectopic Pregnancy |
| NCT02793089 | Not specified | COMPLETED | Risk of Ectopic Pregnancy and Variation of Luteal Estradiol and Progesterone Levels in IVF |
| NCT02831556 | Not specified | COMPLETED | Point of Care 3D Ultrasound for Various Applications: A Pilot Study |
| NCT02963012 | Not specified | UNKNOWN | The Correlation Between Uterine Endometrial Pattern and Ectopic Pregnancy |
| NCT02973230 | Not specified | COMPLETED | Serum VEGF as a Tubal Pregnancy Marker |
| NCT02995356 | Not specified | COMPLETED | Evaluation of the Axonemal Dynein Heavy Chain 5 and Creatine Kinase Concentration in Cervical Fluid for Early Detection of the Ectopic Pregnancy |
| NCT03138694 | Not specified | UNKNOWN | Adnexal Mass After Methotrexate Treatment for Ectopic Pregnancies |
| NCT03253588 | Not specified | COMPLETED | Laparoscopic Tubal Preservation Surgery |
| NCT03327688 | Not specified | COMPLETED | Point-of-care Ultrasound in Finland |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| METHOTREXATE | 4 | 13 |
| CETRORELIX | 4 | 2 |
| LETROZOLE | 4 | 2 |
| GONADORELIN ACETATE | 4 | 1 |
| NALBUPHINE | 4 | 1 |
| TRIPTORELIN | 4 | 1 |
| CHEMBL426 | 0 | 2 |
| CHEMBL2370644 | 0 | 1 |