Enamel caries

Summary

Enamel caries (MONDO:0002233) is a disease and 6 clinical trials. A subtype of dental caries — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 6

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	enamel caries
Mondo ID	MONDO:0002233
DOID	DOID:217
SNOMED CT	80353004
UMLS	C0266853
MedGen	540214
Anatomy (UBERON)	UBERON:0001752
Is cancer (heuristic)	no

Also known as: dental caries limited to enamel · dental caries of enamel · enamel dental caries

Disease family

This is a subtype of dental caries. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › tooth disorder › tooth hard tissue disease › dental caries › enamel caries

Related subtypes (4): dentin caries, odontoclasia, pit and fissure surface dental caries, smooth surface dental caries

Subtypes (1): root caries

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 6.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	6

Top trials by phase / activity

NCT	Phase	Status	Title
NCT03774498	Not specified	UNKNOWN	Effect of Different Over-the-counter Toothpastes on Enamel Remineralization
NCT04155658	Not specified	COMPLETED	Evaluation of Efficacy of Sodium Monofluorophosphate (SMPF) Toothpastes on Enamel Lesion Remineralisation
NCT04685889	Not specified	COMPLETED	Resin Infiltration Treatment for MIH
NCT04756557	Not specified	COMPLETED	Caries-preventing Effect of a Hydroxyapatite-toothpaste in Adults
NCT05296213	Not specified	COMPLETED	Medical Treatment of Early-Enamel Carious Lesion Using Different Remeneralizing Agents
NCT06425536	Not specified	COMPLETED	Efficacy of Remineralizing Products Used in Molar Grooves: Evaluation With Diagnodent Pen and Diagnocam