Encephalitis lethargica
diseaseOn this page
Also known as epidemic encephalitislethargic encephalitisVon Economo encephalitisvon Economo's diseaseVon Economo’s disease
Summary
Encephalitis lethargica (MONDO:0019384) is a disease. A subtype of viral encephalitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Prevalence: <1 / 1 000 000 (Europe)
- Phenotypes (HPO): 30
Clinical features
Epidemiology
Prevalence records
1 prevalence record(s), Orphanet:
| Type | Class | Value | Geography | Validation |
|---|---|---|---|---|
| Point prevalence | <1 / 1 000 000 | Europe | Not yet validated |
Signs & symptoms
Clinical features (HPO)
30 HPO clinical features (Orphanet curated; top 30 by frequency):
| HPO ID | Term | Frequency |
|---|---|---|
| HP:0001298 | Encephalopathy | Very frequent (80-99%) |
| HP:0002360 | Sleep abnormality | Very frequent (80-99%) |
| HP:0000651 | Diplopia | Frequent (30-79%) |
| HP:0001254 | Lethargy | Frequent (30-79%) |
| HP:0001268 | Mental deterioration | Frequent (30-79%) |
| HP:0001300 | Parkinsonism | Frequent (30-79%) |
| HP:0001337 | Tremor | Frequent (30-79%) |
| HP:0001945 | Fever | Frequent (30-79%) |
| HP:0002315 | Headache | Frequent (30-79%) |
| HP:0002922 | Increased CSF protein concentration | Frequent (30-79%) |
| HP:0002960 | Autoimmunity | Frequent (30-79%) |
| HP:0003326 | Myalgia | Frequent (30-79%) |
| HP:0003484 | Upper limb muscle weakness | Frequent (30-79%) |
| HP:0004429 | Recurrent viral infections | Frequent (30-79%) |
| HP:0005986 | Limitation of neck motion | Frequent (30-79%) |
| HP:0007146 | Bilateral basal ganglia lesions | Frequent (30-79%) |
| HP:0010702 | Increased circulating antibody level | Frequent (30-79%) |
| HP:0012547 | Abnormal involuntary eye movements | Frequent (30-79%) |
| HP:0025439 | Pharyngitis | Frequent (30-79%) |
| HP:0100660 | Dyskinesia | Frequent (30-79%) |
| HP:0000020 | Urinary incontinence | Occasional (5-29%) |
| HP:0000613 | Photophobia | Occasional (5-29%) |
| HP:0000709 | Psychosis | Occasional (5-29%) |
| HP:0001250 | Seizure | Occasional (5-29%) |
| HP:0001259 | Coma | Occasional (5-29%) |
| HP:0001662 | Bradycardia | Occasional (5-29%) |
| HP:0002607 | Bowel incontinence | Occasional (5-29%) |
| HP:0002883 | Hyperventilation | Occasional (5-29%) |
| HP:0009763 | Limb pain | Occasional (5-29%) |
| HP:0025258 | Stiff neck | Occasional (5-29%) |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | encephalitis lethargica |
| Mondo ID | MONDO:0019384 |
| Orphanet | 83600 |
| DOID | DOID:5225 |
| ICD-11 | 1777779617 |
| NCIT | C26761, C34576 |
| SNOMED CT | 186499007 |
| UMLS | C0014040 |
| MedGen | 4028 |
| GARD | 0006332 |
| MedDRA | 10052369 |
| Is cancer (heuristic) | no |
Also known as: encephalitis lethargica · epidemic encephalitis · lethargic encephalitis · Von Economo encephalitis · von Economo’s disease · Von Economo’s disease
Disease family
This is a subtype of viral encephalitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › nervous system disorder › central nervous system disorder › encephalomyelitis › encephalitis › infectious encephalitis › viral encephalitis › encephalitis lethargica
Related subtypes (11): Powassan encephalitis, acute necrotizing encephalitis, acute hemorrhagic encephalitis, Colorado tick fever, eastern equine encephalitis, subacute sclerosing panencephalitis, herpes simplex encephalitis, tick-borne encephalitis, mosquito-borne viral encephalitis, HHV-6 encephalitis, borna virus encephalitis
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 0.
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.