Endometrial polyp

Summary

Endometrial polyp (MONDO:0006195) is a disease and 25 clinical trials. Top therapeutic interventions include estetrol anhydrous, dienogest, and drospirenone. A subtype of endometrial disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 25

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	endometrial polyp
Mondo ID	MONDO:0006195
EFO	EFO:1000237
NCIT	C6433
UMLS	C1704273
MedGen	312370
Anatomy (UBERON)	UBERON:0001295
Is cancer (heuristic)	no

Also known as: endometrial polyp · endometrial stromal polyp · endometrium polyp · polyp of endometrium · polyp of the endometrium · polyp, endometrial stromal, benign

Disease family

This is a subtype of endometrial disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › reproductive system disorder › female reproductive system disorder › uterine disorder › endometrial disorder › endometrial polyp

Related subtypes (6): endometritis, tamoxifen-related endometrial lesion, endometriosis, atypical endometrial hyperplasia, adenomyosis, endometrium neoplasm

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 25.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	18
PHASE4	5
PHASE3	2

Top trials by phase / activity

NCT	Phase	Status	Title
NCT03790215	PHASE4	COMPLETED	Dydrogesterone in the Treatment of Endometrial Polyps
NCT06316180	PHASE4	COMPLETED	The Use of Drospirenone/Estetrol in Random Start Rapid Endometrial Preparation
NCT06316206	PHASE4	COMPLETED	The Use of Ethinylestradiol/Dienogest in Random Start Rapid Endometrial Preparation
NCT06316219	PHASE4	COMPLETED	The Use of Nomegestrol Acetate/Estradiol in Random Start Rapid Endometrial Preparation
NCT06324851	PHASE4	COMPLETED	The Use of Drospirenone/Estetrol, Nomegestrol Acetate/Estradiol and Ethinylestradiol/Dienogest in Random Start Rapid Endometrial Preparation
NCT01509313	PHASE3	COMPLETED	A Trial Comparing Morcellation With Electrical Resection for Removal of Uterine Polyps
NCT03309709	PHASE3	UNKNOWN	Endometrial Polyps Regression With Progesterone Therapy
NCT06526962	Not specified	RECRUITING	5Fr Bipolar Electrode vs. Conical Optical 5Fr Fibers for Dual Wave-length Diode Laser for Hysteroscopic Polypectomy
NCT06620939	Not specified	NOT_YET_RECRUITING	The Effect of Levonorgestrel Intrauterine System in Preventing Endometrial Polyps Recurrence
NCT06620978	Not specified	NOT_YET_RECRUITING	Impact of Different Saline Pressures During Hysteroscopy on Visibility, Feasibility and Patients’ Discomfort
NCT07048327	Not specified	RECRUITING	Cohort Study of Intrauterine Diseases
NCT07074795	Not specified	ACTIVE_NOT_RECRUITING	Use of Nitrous Oxide During Office Hysteroscopy
NCT00247923	Not specified	COMPLETED	Endometrial Polyps: Pathophysiology and Clinical Consequences
NCT01637974	Not specified	UNKNOWN	Efficiency of INTERCOAT (Oxiplex/AP Gel) in Preventing Intrauterine Adhesion Formation in Hysteroscopic Surgery
NCT02126397	Not specified	COMPLETED	Comparative Study of Endometrial Polypectomy Performed With Bipolar Electrode Versapoint and Laser Diode. A Randomised Controlled Trial.
NCT02472197	Not specified	COMPLETED	Morcellator Versus Resectoscope in the Treatment of Uterine Polyps by Hysteroscopy
NCT02520414	Not specified	COMPLETED	Symphion® System In-Office Study
NCT02590666	Not specified	UNKNOWN	Endometrial Polypectomy Performed With Bipolar Electrode Versapoint vs Microscissors or Graspers
NCT03207126	Not specified	COMPLETED	Pilot Study: Can Ultrasound Guided Biopsy be Used as an Alternative to Hysteroscopy?
NCT04706000	Not specified	COMPLETED	Autophagy Markers in Endometrial Polyps
NCT05049395	Not specified	UNKNOWN	HFNO Reducing the Incidence of Hypoxia for Hysteroscopy Sedated With Propofol
NCT05337046	Not specified	COMPLETED	Hysteroscopic Tissue Removal System Versus Bipolar Resectoscopy for Polypectomy: Long-term Results
NCT05337605	Not specified	COMPLETED	Hand Driven Versus Motor Driven Hysteroscopic Tissue Removal System for Polypectomy: Long-term Results
NCT06295510	Not specified	UNKNOWN	Observational Study of the Association Between Food Intake and Endometrial Polyps
NCT06826495	Not specified	COMPLETED	Thiol Disulfide Balance and Oxidative Stress Change in Endometrial Polyp Patients

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
ESTETROL ANHYDROUS	4	4
DIENOGEST	4	2
DROSPIRENONE	4	2
ETHINYL ESTRADIOL	4	2
NOMEGESTROL ACETATE	4	2
DYDROGESTERONE	4	1
ESTRADIOL	4	1
CHEMBL1078369	0	2