Endometrioid tumor

Summary

Endometrioid tumor (MONDO:0002480) is a cancer and 4 clinical trials. Top therapeutic interventions include pasifolate exatecan. A subtype of epithelial neoplasm — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Clinical trials: 4

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	endometrioid tumor
Mondo ID	MONDO:0002480
DOID	DOID:3001
NCIT	C7113
UMLS	C0474809
MedGen	105374
Is cancer (heuristic)	yes

Also known as: endometrioid neoplasm · endometrioid neoplasm of female reproductive system · endometrioid neoplasm of the female reproductive system · endometrioid tumor · endometrioid tumor (morphologic abnormality) · endometrioid tumor of female reproductive system · endometrioid tumor of the female reproductive system · endometrioid tumour (morphologic abnormality) · endometrioid tumour of female reproductive system · endometrioid tumour of the female reproductive system · female reproductive endometrioid neoplasm · female reproductive endometrioid tumor · female reproductive endometrioid tumour

Disease family

An umbrella term covering 1 Mondo subtype.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › epithelial neoplasm › endometrioid tumor

Related subtypes (23): ovarian epithelial tumor, myoepithelial tumor, squamous cell neoplasm, pancreatic delta cell neuroendocrine tumor, thyroid hyalinizing trabecular adenoma, Wolffian adnexal tumor, adenoma, carcinoma, cystic, mucinous, and serous neoplasm, thymic epithelial neoplasm, epithelial tumor of anal canal, growth hormone-producing pituitary gland neoplasm, basal cell neoplasm, sympathetic paraganglioma, papillary epithelial neoplasm, epithelial skin neoplasm, glandular cell neoplasm, intraepithelial neoplasia, epithelial neoplasm of rectum, epithelial tumor of colon, mesonephric neoplasm, benign epithelial neoplasm, transitional cell neoplasm

Subtypes (1): ovarian endometrial cancer

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 4.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE1/PHASE2	1
PHASE2	1
PHASE1	1
Not specified	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT05997017	PHASE2	RECRUITING	Trial of Nab-Sirolimus in Combination With Letrozole in Patients With Advanced or Recurrent Endometrioid Endometrial Cancer
NCT05001282	PHASE1/PHASE2	TERMINATED	A Study to Evaluate ELU001 in Patients With Solid Tumors That Overexpress Folate Receptor Alpha (FRα)
NCT05274451	PHASE1	TERMINATED	A Study to Investigate LYL797 in Adults With Solid Tumors
NCT05891197	Not specified	TERMINATED	A Biomarker Screening Protocol for Participants With Solid Tumors

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
PASIFOLATE EXATECAN	1	1