Endometritis
diseaseOn this page
Also known as endometrium inflammationinflammation of endometriumuterine infection
Summary
Endometritis (MONDO:0000918) is a disease and 25 clinical trials. Top therapeutic interventions include doxycycline anhydrous, cefazolin, and ampicillin. A subtype of endometrial disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 25
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | endometritis |
| Mondo ID | MONDO:0000918 |
| EFO | EFO:1001312 |
| MeSH | D004716 |
| DOID | DOID:1002 |
| NCIT | C26764 |
| SNOMED CT | 78623009 |
| UMLS | C0014179 |
| MedGen | 41789 |
| Is cancer (heuristic) | no |
Also known as: endometrium inflammation · inflammation of endometrium · uterine infection
Disease family
This is a subtype of endometrial disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › reproductive system disorder › female reproductive system disorder › uterine disorder › endometrial disorder › endometritis
Related subtypes (6): tamoxifen-related endometrial lesion, endometriosis, atypical endometrial hyperplasia, endometrial polyp, adenomyosis, endometrium neoplasm
Subtypes (3): acute endometritis, chronic endometritis, endomyometritis
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
Drugs indicated for this disease
2 approved. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.
| Drug | Development status |
|---|---|
| Clindamycin | Approved (phase 4) |
| Clindamycin Phosphate | Approved (phase 4) |
Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Ceftriaxone.
Clinical trials & evidence
Clinical trials
Clinical trials: 25.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 20 |
| PHASE4 | 2 |
| PHASE2 | 2 |
| PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00547170 | PHASE4 | COMPLETED | Doxycycline Prophylaxis at Vacuum Aspiration Trial |
| NCT01721616 | PHASE4 | WITHDRAWN | Comparison Study of Cefazolin Versus Cefazolin Plus Azithromycin Prophylaxis in Post-Cesarean Endometritis |
| NCT02742948 | PHASE2 | UNKNOWN | The Optimal Time for Intravenous Antibiotic Prophylaxis in Elective Cesarean Section |
| NCT03960970 | PHASE2 | UNKNOWN | Two-drug Antibiotic Prophylaxis in Scheduled Cesarean Deliveries |
| NCT01587495 | PHASE1 | TERMINATED | Pharmacokinetics and Safety of Ertapenem in the Postpartum Period |
| NCT07265505 | Not specified | NOT_YET_RECRUITING | Study of Endometrial Immune and Microbiological Modifications in Cases of Recurrent Implantation Failure and/or Recurrent Pregnancy Loss |
| NCT07603492 | Not specified | RECRUITING | Fertility Outcomes After Antibiotic Treatment In Women With Chronic Endometritis |
| NCT00330278 | Not specified | COMPLETED | Timing of Prophylactic Antibiotics for Cesarean Sections |
| NCT00386477 | Not specified | TERMINATED | Vaginal Cleansing at Cesarean Delivery to Reduce Infection: A Randomized, Controlled Trial |
| NCT00500019 | Not specified | COMPLETED | Uterine Flora During Elective and Urgent Cesarean Sections |
| NCT00501033 | Not specified | COMPLETED | A Prospective Comparative Study of Induction of Labor With a Cervical Ripening Double Balloon vs Foley Catheter |
| NCT00603603 | Not specified | COMPLETED | Controlled Clinical Trial of Supplemental Oxygen for the Prevention of Post-Cesarean Infectious Morbidity |
| NCT00858832 | Not specified | COMPLETED | Reduction of Endometritis After Cesarean Section With the Routine Use of Methergine |
| NCT01235546 | Not specified | COMPLETED | Study of Effectiveness and Safety of Azithromycin-based Extended-spectrum Prophylaxis to Prevent Post Cesarean Infection |
| NCT01464840 | Not specified | COMPLETED | The Pharmacokinetics of Azithromycin Prophylaxis for Cesarean Delivery |
| NCT01762098 | Not specified | COMPLETED | Chronic Endometritis in Patients With Recurrent Miscarriages or Repeated Implantation Failures in In-vitro Fertilization |
| NCT01945450 | Not specified | UNKNOWN | Prophylactic Antibiotics for Manual Removal of Retained Placenta in Vaginal Birth: a Randomized Controlled Trial |
| NCT02402907 | Not specified | COMPLETED | STRIPES Study: Study To Reduce Infection Post cEsarean Section |
| NCT03442218 | Not specified | COMPLETED | Use of Antiseptic Solution for Vaginal Wash Before Cesarean Section |
| NCT03459599 | Not specified | COMPLETED | Antibiotic Prophylaxis in Ragged Placental Membranes |
| NCT04163679 | Not specified | TERMINATED | Vaginal Preparation and Azithromycin to Reduce Post Cesarean Infections |
| NCT04197167 | Not specified | UNKNOWN | Mid-Infrared Spectroscopy as a Real Time Diagnostic Tool for Chronic Endometritis |
| NCT04307069 | Not specified | UNKNOWN | Management of Prelabor Rupture of the Membranes at Term |
| NCT05049395 | Not specified | UNKNOWN | HFNO Reducing the Incidence of Hypoxia for Hysteroscopy Sedated With Propofol |
| NCT06936475 | Not specified | COMPLETED | Vaginal Cleansing With Chlorhexidine Versus Iodine for Prevention of Endometritis |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| DOXYCYCLINE ANHYDROUS | 4 | 3 |
| CEFAZOLIN | 4 | 2 |
| AMPICILLIN | 4 | 1 |
| AZITHROMYCIN | 4 | 1 |
| CEFOXITIN SODIUM | 4 | 1 |
| CEFTRIAXONE | 4 | 1 |
| ERTAPENEM | 4 | 1 |
| GENTAMICIN | 4 | 1 |
| METHYLERGONOVINE MALEATE | 4 | 1 |
| CHEMBL4299381 | 0 | 1 |
| CHEMBL5421678 | 0 | 1 |
| CHEMBL1628 | 0 | 1 |
| 17 | 0 | 1 |
| GENTAMICIN C1 | 0 | 1 |