Enterovirus infectious disease

Summary

Enterovirus infectious disease (MONDO:0005747) is a disease (an umbrella term covering 6 Mondo subtypes) and 18 clinical trials. Top therapeutic interventions include pleconaril and vapendavir. A subtype of Picornaviridae infectious disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Umbrella term: 6 Mondo subtypes
• Clinical trials: 18

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	enterovirus infectious disease
Mondo ID	MONDO:0005747
EFO	EFO:0007255
MeSH	D004769
SNOMED CT	53648006
UMLS	C0014378
MedGen	8647
Anatomy (UBERON)	UBERON:0001555
Is cancer (heuristic)	no

Also known as: disease due to enterovirus · Enterovirus caused disease or disorder · Enterovirus disease or disorder · Enterovirus infection · Enterovirus infectious disease · enterovirus infectious disease · infection, Enterovirus · infections, Enterovirus

Disease family

This is a subtype of Picornaviridae infectious disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › viral infectious disease › primary viral infectious disease › Picornaviridae infectious disease › enterovirus infectious disease

Related subtypes (1): cardiovirus infectious disease

Subtypes (6): coxsackievirus infectious disease, Echovirus infectious disease, congenital enterovirus infection, enterovirus antenatal infection, fetal enterovirus syndrome, poliovirus infection

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 18.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	6
PHASE2	5
PHASE1	5
PHASE4	1
PHASE3	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT04091880	PHASE4	COMPLETED	Evaluation of the Safety and Immunogenicity of Simultaneously Administration of EV71 Vaccine and Influenza Vaccine
NCT05099029	PHASE3	ACTIVE_NOT_RECRUITING	A Study to Evaluate the Efficacy, Immunogenicity and Safety of an EV71 Vaccine in Healthy Infants and Children
NCT00031512	PHASE2	COMPLETED	Pleconaril Enteroviral Sepsis Syndrome
NCT01129232	PHASE2	TERMINATED	Diabetes Virus Detection Project, Intervention With GAD-alum
NCT02777411	PHASE2	COMPLETED	A Study to Evaluate the Safety and Immunogenicity of EV71 Vaccine in Pediatric Subjects Aged 3 to 6 Years and 6 to 35 Months Old
NCT03268083	PHASE2	COMPLETED	A Study to Evaluate the Immunogenicity and Safety of EV71 Vaccine in Pediatric Subjects
NCT06149494	PHASE2	COMPLETED	RCT of Vapendavir in Patients With COPD and Human Rhinovirus/Enterovirus Upper Respiratory Infection
NCT01268787	PHASE1	COMPLETED	A Study to Evaluate the Safety and Immunogenicity of EV71 Vaccine
NCT01313715	PHASE1	COMPLETED	A Clinical Trial for Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children and Infants
NCT02961595	PHASE1	COMPLETED	Live Enterovirus Vaccine and Type 1 Diabetes
NCT05016687	PHASE1	COMPLETED	First-in-human Clinical Trial Evaluating CUR-N399 in Healthy Volunteers.
NCT06444048	PHASE1	COMPLETED	Phase 1, Randomized, Double-Blind, Placebo-controlled Study to Evaluate the Safety and Tolerability of an Enterovirus D68-specific Monoclonal Antibody in Healthy Adults
NCT06263439	Not specified	RECRUITING	Surveillance of HFMD in Pediatric Outpatients
NCT06922474	Not specified	ACTIVE_NOT_RECRUITING	Molecular Epidemiology of Enteroviruses Detected at the Virology Laboratory of Brest University Hospital During the Period 2018-2024: Retrospective Analysis of an Atypical Meningitis Epidemic in 2024 (BrEcho9Men)
NCT00426699	Not specified	COMPLETED	Urinary Excretion of Enteroviruses From Children With a Presumed Enteroviral Infection
NCT04431050	Not specified	TERMINATED	Evaluation of a Single Use Point of Care Device for the Diagnosis of Respiratory Pathogens
NCT04535648	Not specified	WITHDRAWN	Detection of Enterovirus Genotypes by CRISPR Technology
NCT04769167	Not specified	COMPLETED	Congenital Heart Anomaly Risk in Maternal Enteroviral Infection and Diabetes

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
PLECONARIL	2	1
VAPENDAVIR	2	1