Epicondylitis

Summary

Epicondylitis (MONDO:0001875) is a disease and 180 clinical trials. Top therapeutic interventions include triamcinolone acetonide, dextrose, and doxycycline hyclate. A subtype of bone inflammation disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 180

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	epicondylitis
Mondo ID	MONDO:0001875
EFO	EFO:1001887
MeSH	D013716
DOID	DOID:14087
ICD-10-CM	M77.1
NCIT	C34589
SNOMED CT	202855006
UMLS	C0014488
MedGen	4090
Is cancer (heuristic)	no

Also known as: ectepicondyle of humerus inflammation · inflammation of ectepicondyle of humerus · lateral epicondylitis

Disease family

This is a subtype of bone inflammation disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › bone disorder › bone inflammation disease › epicondylitis

Related subtypes (5): mastoiditis, Osgood-Schlatter disease, osteomyelitis, arthritic joint disease, Caffey disease

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

5 approved, 5 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

Drug	Development status
Cortisone Acetate	Approved (phase 4)
Dexamethasone	Approved (phase 4)
Prednisolone	Approved (phase 4)
Prednisone	Approved (phase 4)
Triamcinolone Acetonide	Approved (phase 4)
Abobotulinumtoxina	Phase 3 (in late-stage trials)
Dextrose	Phase 3 (in late-stage trials)
Lidocaine	Phase 3 (in late-stage trials)
Onabotulinumtoxina	Phase 3 (in late-stage trials)
Sodium Chloride	Phase 3 (in late-stage trials)

Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Capsaicin, Fibrin, Methylprednisolone Acetate, Piroxicam, Polidocanol.

Clinical trials & evidence

Clinical trials

Clinical trials: 180.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	145
PHASE2	9
PHASE4	8
PHASE3	8
PHASE2/PHASE3	4
PHASE1	3
PHASE1/PHASE2	2
EARLY_PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT03718637	PHASE4	RECRUITING	Efficacy Bioinductive Implant for Tennis Elbow (Lateral Epicondylitis)
NCT07342426	PHASE4	RECRUITING	High and Low Dose High-intensity Laser Therapy Lateral Epicondylitis
NCT00554476	PHASE4	TERMINATED	Comparison of Two Combined Therapeutic Methods for Treatment of Lateral Epicondylitis
NCT02492945	PHASE4	COMPLETED	Bundang Rehabilitative Impact Study of the Elbow Epicondylitis
NCT02613455	PHASE4	UNKNOWN	Corticosteroid Injection Verses High Energy Extracorporeal Shock Wave Therapy for Lateral Epicondylitis
NCT04382144	PHASE4	UNKNOWN	Levobupivacaine Versus Liposomal Bupivacaine (Exparel®) for Treatment of Pain and Disability in Lateral Epicondylitis
NCT04384809	PHASE4	WITHDRAWN	Platelet Rich Plasma Injection vs Percutaneous Tenotomy for Common Extensor Tendinopathy
NCT04680936	PHASE4	COMPLETED	Low and High Dose Dextrose Prolotherapy in the Treatment of Lateral Epicondylitis
NCT00160303	PHASE3	COMPLETED	Efficacy Study of Prolotherapy vs Corticosteroid for Tennis Elbow
NCT00257634	PHASE3	COMPLETED	Randomized Trial of Iontophoresis Versus Injection of Corticosteroids for Lateral Epicondylitis
NCT00674622	PHASE2/PHASE3	COMPLETED	Prolotherapy for the Treatment of Chronic Lateral Epicondylitis
NCT00725023	PHASE2/PHASE3	TERMINATED	Use of TPD Heat Lamp for Tennis Elbow Pain - a Randomized-controlled Trial
NCT01269879	PHASE3	UNKNOWN	VIBration Training in EpicondylitiS
NCT01273688	PHASE3	UNKNOWN	Eccentric Training With or Without Elbow Brace for Epicondylitis
NCT01945528	PHASE3	COMPLETED	Platelet Rich Plasma (PRP) in Chronic Epicondylitis
NCT01986465	PHASE2/PHASE3	COMPLETED	Effectiveness of Steroid Injection in Treating Patients With Lateral Epicondylitis
NCT02266433	PHASE3	TERMINATED	Dexamethasone Versus Ketorolac Injection for the Treatment of Local Inflammatory Hand and Upper Extremity Disorders
NCT03380559	PHASE3	COMPLETED	A Phase III Study to Evaluate Efficacy of Botulinum Toxin for Treating Epicondylitis
NCT04201249	PHASE2/PHASE3	UNKNOWN	Mesotherapy In Lateral Epicondylitis
NCT05648032	PHASE3	UNKNOWN	PLT and Steroid in Lateral Epicondylopathy and Supraspinatus Calcific Tendinopathy
NCT07111325	PHASE1/PHASE2	RECRUITING	Safety and Preliminary Efficacy of iEVs Injection in Treating Lateral Epicondylitis of Humerus
NCT00794976	PHASE2	COMPLETED	Dexamethasone Iontophoretic Patch for the Treatment of Pain Associated With Lateral Epicondylitis
NCT01185951	PHASE2	UNKNOWN	TENDOSHOCK-2010 Combination Therapy for Athletic Tendinopathies
NCT01618487	PHASE2	UNKNOWN	Comparison of Surgical Interventions for Lateral Epicondylitis: A Prospective Study
NCT01668862	PHASE1/PHASE2	UNKNOWN	A Study to Determine Safety & Efficacy of Autologous Human Platelet Lysate in Lateral Epicondylitis (Tennis Elbow)
NCT01746420	PHASE2	COMPLETED	Phase II Study of the Effects of rhPDGF-BB Injection on Lateral Epicondylitis
NCT01897259	PHASE2	UNKNOWN	Comparison of Conservative Methods for the Treatment of Lateral Epicondylitis: A Randomized, Prospective Study
NCT03279796	PHASE2	UNKNOWN	Treatment of Tendon Disease Using Autologous Adipose-derived Mesenchymal Stem Cells
NCT03300531	PHASE2	UNKNOWN	Impact of Autologous Pure Platelet-rich Plasma in the Treatment of Tendon Disease
NCT03449082	PHASE2	COMPLETED	Treatment of Intractable Common Extensor Tendon Injury Using Mesenchymal Stem Cells (Allo-ASC)
NCT03811145	PHASE2	COMPLETED	An Investigation of Tendoncel, a Novel Topical Platelet Lysate Gel, in the Treatment of Lateral Epicondylitis
NCT06578000	PHASE1	RECRUITING	Efficacy of Iontophoresis in Treating Lateral Epicondylitis Patients
NCT00895076	PHASE1	UNKNOWN	Study to Compare the Pharmacokinetics of a Dexamethasone Iontophoretic Patch to a Dexamethasone Injection
NCT04686799	PHASE1	COMPLETED	Doxycycline for Elbow Tendinopathy
NCT01856140	EARLY_PHASE1	COMPLETED	Treatment of Tendon Injury Using Mesenchymal Stem Cells
NCT03984955	Not specified	RECRUITING	Comparing Injection Treatments for Tennis Elbow
NCT04556825	Not specified	ACTIVE_NOT_RECRUITING	Arthroscopic Treatment Combined With PRP Injection for Refractory Elbow Epicondylitis
NCT05237869	Not specified	RECRUITING	Blood Flow Restriction & Tennis Elbow Rehab
NCT05809622	Not specified	RECRUITING	Upper Extremity-based Exercises and Elbow-focused Exercises in LET
NCT06271915	Not specified	RECRUITING	Role of Cervical Spine Mobilization on Lateral Epicondylitis

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
TRIAMCINOLONE ACETONIDE	4	2
DEXTROSE	4	1
DOXYCYCLINE HYCLATE	4	1
PIROXICAM	4	1
POLIDOCANOL	4	1
ARTEMISININ	3	1
FIBRIN	3	1
CHEMBL423707	0	1
CHEMBL1231723	0	1
CHEMBL1200567	0	1