Erythema elevatum diutinum

Summary

Erythema elevatum diutinum (MONDO:0019526) is a disease and 1 clinical trial. A subtype of immune complex mediated vasculitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: Unknown (Worldwide)
• Phenotypes (HPO): 8
• Clinical trials: 1

Clinical features

Signs & symptoms

Clinical features (HPO)

8 HPO clinical features (Orphanet curated; top 8 by frequency):

HPO ID	Term	Frequency
HP:0000988	Skin rash	Very frequent (80-99%)
HP:0002829	Arthralgia	Very frequent (80-99%)
HP:0200029	Vasculitis in the skin	Very frequent (80-99%)
HP:0008066	Abnormal blistering of the skin	Frequent (30-79%)
HP:0010702	Increased circulating antibody level	Frequent (30-79%)
HP:0200037	Skin vesicle	Frequent (30-79%)
HP:0003326	Myalgia	Occasional (5-29%)
HP:0200036	Skin nodule	Occasional (5-29%)

Identifiers

Disease identifiers

Field	Value
Canonical name	erythema elevatum diutinum
Mondo ID	MONDO:0019526
MeSH	C535509
Orphanet	90000
DOID	DOID:0060567
ICD-10-CM	L95.1
ICD-11	754210950
SNOMED CT	58872001
UMLS	C0263398
MedGen	75517
GARD	0008653
MedDRA	10056968
Is cancer (heuristic)	no

Disease family

This is a subtype of immune complex mediated vasculitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › cardiovascular disorder › vascular disorder › vasculitis › immune complex mediated vasculitis › erythema elevatum diutinum

Related subtypes (4): Cryoglobulinemic vasculitis, hypocomplementemic urticarial vasculitis, immunoglobulin A vasculitis, cutaneous leukocytoclastic angiitis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 1.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT01952275	Not specified	UNKNOWN	Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases