Esophageal small cell neuroendocrine carcinoma

Summary

Esophageal small cell neuroendocrine carcinoma (MONDO:0004116) is a cancer and 3 clinical trials. Top therapeutic interventions include toripalimab and adebrelimab. A subtype of small cell carcinoma — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Clinical trials: 3

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	esophageal small cell neuroendocrine carcinoma
Mondo ID	MONDO:0004116
DOID	DOID:7134
NCIT	C6762
UMLS	C1112474
MedGen	207270
GARD	0023832
Anatomy (UBERON)	UBERON:0001043
Is cancer (heuristic)	yes

Also known as: esophageal Oat cell carcinoma · esophageal small cell carcinoma · esophageal small cell NEC · esophageal small cell neuroendocrine carcinoma · esophagus Oat cell carcinoma · esophagus small cell carcinoma · Oat cell carcinoma of esophagus · Oat cell carcinoma of the esophagus · Oat cell carcinoma of the oesophagus · oesophagus Oat cell carcinoma · small cell carcinoma of esophagus · small cell carcinoma of oesophagus · small cell carcinoma of the esophagus · small cell carcinoma of the oesophagus · small cell carcinoma, esophagus · small cell carcinoma, oesophagus

Data availability: 3 cell lines.

Disease family

This is a subtype of small cell carcinoma. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › cancer › carcinoma › neuroendocrine carcinoma › small cell carcinoma › esophageal small cell neuroendocrine carcinoma

Related subtypes (17): extrahepatic bile duct small cell adenocarcinoma, ovarian small cell carcinoma, colon small cell neuroendocrine carcinoma, urinary bladder small cell neuroendocrine carcinoma, ampulla of vater small cell neuroendocrine carcinoma, Bartholin gland small cell carcinoma, thymus small cell carcinoma, cervical small cell carcinoma, endometrial small cell carcinoma, gallbladder small cell neuroendocrine carcinoma, gastric small cell neuroendocrine carcinoma, laryngeal small cell carcinoma, pancreatic small cell neuroendocrine carcinoma, prostate small cell carcinoma, salivary gland small cell carcinoma, ureter small cell carcinoma, small cell lung carcinoma

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 3.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE2	3

Top trials by phase / activity

NCT	Phase	Status	Title
NCT05173246	PHASE2	RECRUITING	JS001 Combined With TP as First-line Treatment for Unresectable or Advanced Small Cell Esophageal Carcinoma
NCT06478264	PHASE2	NOT_YET_RECRUITING	A Study of Adebrelimab Combined With Chemoradiotherapy in the Treatment of Esophageal Small Cell Carcinoma
NCT03811379	PHASE2	UNKNOWN	Toripalimab as Monotherapy for Patients With Small Cell Carcinoma of Esophagus Who Failed Chemotherapy

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
TORIPALIMAB	4	2
ADEBRELIMAB	3	1