Ethylene glycol poisoning

Summary

Ethylene glycol poisoning (MONDO:0017861) is a disease. A subtype of poisoning — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: Unknown (Worldwide)
• Phenotypes (HPO): 44

Clinical features

Signs & symptoms

Clinical features (HPO)

44 HPO clinical features (Orphanet curated; top 44 by frequency):

HPO ID	Term	Frequency
HP:0001942	Metabolic acidosis	Very frequent (80-99%)
HP:0003128	Lactic acidosis	Very frequent (80-99%)
HP:0001251	Ataxia	Frequent (30-79%)
HP:0001289	Confusion	Frequent (30-79%)
HP:0001350	Slurred speech	Frequent (30-79%)
HP:0001649	Tachycardia	Frequent (30-79%)
HP:0002013	Vomiting	Frequent (30-79%)
HP:0002018	Nausea	Frequent (30-79%)
HP:0002329	Drowsiness	Frequent (30-79%)
HP:0002789	Tachypnea	Frequent (30-79%)
HP:0002901	Hypocalcemia	Frequent (30-79%)
HP:0031844	Euphoria	Frequent (30-79%)
HP:0031962	Elevated serum anion gap	Frequent (30-79%)
HP:0000083	Renal insufficiency	Occasional (5-29%)
HP:0000822	Hypertension	Occasional (5-29%)
HP:0000961	Cyanosis	Occasional (5-29%)
HP:0001259	Coma	Occasional (5-29%)
HP:0001635	Congestive heart failure	Occasional (5-29%)
HP:0001657	Prolonged QT interval	Occasional (5-29%)
HP:0002153	Hyperkalemia	Occasional (5-29%)
HP:0002315	Headache	Occasional (5-29%)
HP:0002615	Hypotension	Occasional (5-29%)
HP:0002793	Abnormal pattern of respiration	Occasional (5-29%)
HP:0004885	Episodic respiratory distress	Occasional (5-29%)
HP:0005110	Atrial fibrillation	Occasional (5-29%)
HP:0005263	Gastritis	Occasional (5-29%)
HP:0007695	Abnormal pupillary light reflex	Occasional (5-29%)
HP:0030955	Alcoholism	Occasional (5-29%)
HP:0031273	Shock	Occasional (5-29%)
HP:0100598	Pulmonary edema	Occasional (5-29%)
HP:0000124	Renal tubular dysfunction	Very rare (<1-4%)
HP:0000602	Ophthalmoplegia	Very rare (<1-4%)
HP:0000639	Nystagmus	Very rare (<1-4%)
HP:0000790	Hematuria	Very rare (<1-4%)
HP:0001250	Seizure	Very rare (<1-4%)
HP:0001298	Encephalopathy	Very rare (<1-4%)
HP:0001336	Myoclonus	Very rare (<1-4%)
HP:0002045	Hypothermia	Very rare (<1-4%)
HP:0002181	Cerebral edema	Very rare (<1-4%)
HP:0008682	Renal tubular epithelial necrosis	Very rare (<1-4%)
HP:0010628	Facial palsy	Very rare (<1-4%)
HP:0011037	Decreased urine output	Very rare (<1-4%)
HP:0030157	Flank pain	Very rare (<1-4%)
HP:0031910	Abnormal cranial nerve physiology	Very rare (<1-4%)

Identifiers

Disease identifiers

Field	Value
Canonical name	ethylene glycol poisoning
Mondo ID	MONDO:0017861
Orphanet	31826
SNOMED CT	426692001
GARD	0018805
Is cancer (heuristic)	no

Disease family

This is a subtype of poisoning. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › poisoning › ethylene glycol poisoning

Related subtypes (58): toxic oil syndrome, infantile mercury poisoning, ketamine-induced biliary dilatation, manganese poisoning, cyanide-induced parkinsonism, colchicine poisoning, methanol poisoning, paraquat poisoning, lead poisoning, mercury poisoning, acute opioid poisoning, acute tricyclic antidepressant poisoning, acute poisoning by drugs with membrane-stabilizing effect, snakebite envenomation, paracetamol poisoning, cyanide poisoning, scorpion envenomation, argyria, acute ackee fruit intoxication, cocaine intoxication, systemic monochloroacetate poisoning, water intoxication, cassavism, formaldehyde poisoning, heavy metal poisoning, abacavir toxicity, allopurinol toxicity, codeine toxicity, efavirenz toxicity, flucloxacilline toxicity, isoniazid toxicity, raltegravir toxicity, voriconazole toxicity, curariform drugs toxicity, statin toxicity, phenytoin or carbamazepine toxicity, letrozole toxicity, ricin poisoning, ivermectin toxicity, belinostat toxicity or dose selection, toxicity to dolutegravir, mycotoxicosis, ciguatera fish poisoning, lathyrism, cadmium poisoning, phenytoin toxicity, nerve agent poisoning, local anesthetic poisoning, fire ant poisoning, aflatoxicosis, black widow spider envenomation, platinum-induced ototoxicity, carbon monoxide poisoning, organophosphate poisoning, sulfur mustard poisoning, cardiac glycoside intoxication, monochloroacetic acid poisoning, chemotherapy-induced toxicity

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.