Excessive tearing
disease diseaseOn this page
Also known as apparatus disease, lacrimalapparatus diseases, lacrimaldisease, lacrimal apparatusdiseases, lacrimal apparatusepiphoralacrimal apparatus disease
Summary
Excessive tearing (MONDO:0001793) is a disease and 28 clinical trials. Top therapeutic interventions include proparacaine, botulinum toxin type a, and nepafenac. A subtype of lacrimal apparatus disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 28
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | excessive tearing |
| Mondo ID | MONDO:0001793 |
| DOID | DOID:13757 |
| ICD-10-CM | H04.2 |
| SNOMED CT | 193982009 |
| UMLS | C0152227 |
| MedGen | 57518 |
| Is cancer (heuristic) | no |
Also known as: apparatus disease, lacrimal · apparatus diseases, lacrimal · disease, lacrimal apparatus · diseases, lacrimal apparatus · epiphora · lacrimal apparatus disease
Disease family
This is a subtype of lacrimal apparatus disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › disorder of orbital region › eye adnexa disorder › lacrimal apparatus disorder › excessive tearing
Related subtypes (16): lacrimal passage granuloma, eversion of lacrimal punctum, stenosis of lacrimal punctum, stenosis of lacrimal passage, primary lacrimal atrophy, secondary lacrimal atrophy, lacrimal system cancer, stenosis of lacrimal sac, acute inflammation of lacrimal passage, chronic inflammation of lacrimal passage, dry eye syndrome, IgG4-related dacryoadenitis and sialadenitis, isolated congenital alacrima, disorder of lacrimal gland, nasolacrimal duct disorder, syndromic lacrimal system disorder
Subtypes (2): epiphora due to insufficient drainage, epiphora due to excess lacrimation
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 28.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 16 |
| PHASE4 | 4 |
| PHASE2 | 4 |
| PHASE3 | 1 |
| PHASE2/PHASE3 | 1 |
| PHASE1 | 1 |
| EARLY_PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT05663684 | PHASE4 | RECRUITING | Does Topical Ophthalmic Proparacaine 0.5% Prior to Probing and Irrigation Decrease Pain? |
| NCT07372014 | PHASE4 | ACTIVE_NOT_RECRUITING | A Comparative Analysis of the Effectiveness of Nepafenac Combined With a Lubricant Versus a Lubricant Alone in the Treatment of Epiphora Associated With Lacrimal Punctum Stenosis |
| NCT01010659 | PHASE4 | COMPLETED | The Safety and Efficacy of Lacrimal Silicone Intubation for the Management of Epiphora |
| NCT04229771 | PHASE4 | TERMINATED | Does Topical Ophthalmic Anesthetic Prior to Probing and Irrigation Decrease Pain? |
| NCT03436576 | PHASE3 | UNKNOWN | Efficacy of Two Concentrations of Autologous Serum for the Treatment of Severe Dry Eye |
| NCT04637633 | PHASE2/PHASE3 | COMPLETED | Topical Cyclosporine-A for Management of Epiphora |
| NCT00001598 | PHASE2 | COMPLETED | DHEA Treatment for Sjogren’s Syndrome |
| NCT00824811 | PHASE2 | WITHDRAWN | Topical Cyclosporine vs. Placebo for Epiphora Associated With Docetaxel |
| NCT01282541 | PHASE2 | COMPLETED | Determination of the Optimum Delivery Route for Botulinum Toxin A in Patients With Epiphora |
| NCT03266081 | PHASE2 | WITHDRAWN | Bupivacaine Epiphora Trial |
| NCT00266838 | PHASE1 | COMPLETED | Prevention of Docetaxel Induced Dacryostenosis |
| NCT02240615 | EARLY_PHASE1 | COMPLETED | The Sinopsys Lacrimal Stent for Lacrimal System Repair in Epiphora |
| NCT00706251 | Not specified | COMPLETED | Follow up of Nasolacrimal Intubation in Adults |
| NCT01579344 | Not specified | UNKNOWN | Lacrimal Drainage System Obstruction Associated to Radioactive Iodine Therapy for Thyroid Carcinoma |
| NCT01766232 | Not specified | COMPLETED | Lacrimal Drainage Resistance Study |
| NCT01826734 | Not specified | COMPLETED | Analysis of 86 Dacryoliths at the University Hospital Ostrava |
| NCT02386774 | Not specified | COMPLETED | Innovative Imaging of the Conjunctiva, Cornea, and Ocular Adnexa |
| NCT02503956 | Not specified | COMPLETED | Perforated Punctal Plugs for Treatment of Papillary Conjunctivitis in Otherwise Healthy Patients |
| NCT02849093 | Not specified | UNKNOWN | Optical Coherence Tomography of Ocular Structures in Epiphora and Dry Eye Syndrome. |
| NCT03705000 | Not specified | TERMINATED | SLlt Stent II Lacrimal Stent for the Treatment of Nasolacrimal Duct Obstruction |
| NCT03706443 | Not specified | COMPLETED | Tear Lipid Layer Thickness Changes With Use of Emollient and Non-Emollient Eye Drops |
| NCT03731143 | Not specified | COMPLETED | Management of Lower Punctal Stenosis. |
| NCT04240431 | Not specified | COMPLETED | Level of Lacrimal Passage Obstruction |
| NCT04680078 | Not specified | UNKNOWN | Placement of Three Interrupted Sutures After Triangular Three-snip Punctoplasty |
| NCT04833452 | Not specified | UNKNOWN | Comparative Study Between Wide and Narrow Fenstrum Endoscopic DCR |
| NCT04968561 | Not specified | UNKNOWN | Design of an Augmented Reality System by Integration of CT Scan or MRI Data With Endoscopic Images for Video-assisted Endonasal Endoscopic Surgery |
| NCT06428266 | Not specified | COMPLETED | Closed Dacryointubation vs Bicanalicular Intubation for Proximal Tear Duct Obstruction |
| NCT06810089 | Not specified | COMPLETED | Examination of Lacrimal Sac and Nasal Mucosa Preparations Taken in Dacryocystorhinostomy Surgery of Patients With Nasolacrimal Duct Obstruction and Comparison of Clinical Groups With Each Other |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| PROPARACAINE | 4 | 2 |
| BOTULINUM TOXIN TYPE A | 4 | 1 |
| NEPAFENAC | 4 | 1 |
| PRASTERONE | 4 | 1 |
| CHEMBL31399 | 0 | 1 |