Exotropia
diseaseOn this page
Also known as divergent concomitant strabismusdivergent strabismus
Summary
Exotropia (MONDO:0001286) is a disease and 44 clinical trials. Top therapeutic interventions include botulinum toxin type a and sodium chloride. A subtype of strabismus — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- ClinVar variants: 3
- Clinical trials: 44
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | exotropia |
| Mondo ID | MONDO:0001286 |
| MeSH | D005099 |
| DOID | DOID:1143 |
| ICD-10-CM | H50.1 |
| ICD-11 | 2116859618 |
| NCIT | C34601 |
| SNOMED CT | 399252000 |
| UMLS | C0015310 |
| MedGen | 4613 |
| Is cancer (heuristic) | no |
Also known as: divergent concomitant strabismus · divergent strabismus
Data availability: 3 ClinVar variants.
Disease family
This is a subtype of strabismus. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › nervous system disorder › cranial nerve neuropathy › ocular motility disease › strabismus › exotropia
Related subtypes (10): paralytic strabismus, conjugate gaze palsy, intermittent squint, internuclear ophthalmoplegia, mechanical strabismus, hypertropia, cyclotropia, esotropia, hypotropia, monofixation syndrome
Subtypes (2): alternating exotropia, monocular exotropia
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
ClinVar germline variants
3 retrieved; paginated sample, class counts are floors:
2 uncertain significance, 1 pathogenic
| ClinVar | Variant (HGVS) | Gene | Classification | Review |
|---|---|---|---|---|
| 267883 | 46;X;inv(X)(p11.4q24)dn | Pathogenic | criteria provided, single submitter | |
| 267823 | 46;XY;t(6;11)(q23;q21)or(q25;q21)dn | Uncertain significance | criteria provided, single submitter | |
| 267942 | 46;XY;t(1;14)(q42;q13) | Uncertain significance | criteria provided, single submitter |
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 44.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 40 |
| PHASE2/PHASE3 | 2 |
| PHASE4 | 1 |
| PHASE3 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT01460355 | PHASE4 | COMPLETED | Comparison of Two Treatments for Strabismus Correction: Botulinum Toxin A Associated to Surgery and Surgery Alone |
| NCT01616108 | PHASE2/PHASE3 | UNKNOWN | Bupivacaine Injection of Eye Muscles to Treat Strabismus |
| NCT03768362 | PHASE2/PHASE3 | UNKNOWN | Comparison of Medial Rectus Resection and Plication in Exotropic Patients |
| NCT05462821 | PHASE3 | COMPLETED | Full-Time Occlusion Therapy for Intermittent Exotropia in Children |
| NCT04199871 | Not specified | ACTIVE_NOT_RECRUITING | Improving Control of Alignment in Intermittent Exotropia |
| NCT04487249 | Not specified | RECRUITING | Trial of Vision Therapy for Intermittent Exotropia |
| NCT05379855 | Not specified | RECRUITING | A-eyedrops on Ocular Alignment and Binocular Vision |
| NCT06594666 | Not specified | NOT_YET_RECRUITING | Visual Training for Improving Intermittent Exotropia Visual Function |
| NCT06650735 | Not specified | ACTIVE_NOT_RECRUITING | Bilateral Lateral Rectus Recession Versus Bilateral Primary Medial Rectus Resection in Intermittent Exotropia |
| NCT06762067 | Not specified | NOT_YET_RECRUITING | Exercise Training on a Mirror for Intermittent Exotropia Control Post Strabismus Surgery |
| NCT07272005 | Not specified | RECRUITING | Improving Control of Intermittent Exotropia |
| NCT07350330 | Not specified | RECRUITING | Comparative Study of Muscle Transplantation Versus Y Splitting Recession Technique in Treatment of Large Angle Exotropia |
| NCT07446621 | Not specified | NOT_YET_RECRUITING | Risk Factors And Surgical Outcomes Of Strabismus Reoperation |
| NCT01032330 | Not specified | COMPLETED | Observation Versus Occlusion Therapy for Intermittent Exotropia |
| NCT01032603 | Not specified | COMPLETED | Bilateral Lateral Rectus Recession Versus Unilateral Recess-Resect for Intermittent Exotropia |
| NCT01267500 | Not specified | TERMINATED | Study of Non-surgical Treatment Versus Observation in Asian Children With Intermittent Exotropia |
| NCT02131792 | Not specified | COMPLETED | Early Results of Slanted Recession of the Lateral Rectus Muscle for Intermittent Exotropia With Convergence Weakness |
| NCT02223650 | Not specified | COMPLETED | A Pilot Clinical Trial of Overminus Spectacle Therapy for Intermittent Exotropia |
| NCT02383381 | Not specified | COMPLETED | Lateral Rectus Muscle and Anterior Segment Optical Coherence Tomography (AS-OCT) |
| NCT02450162 | Not specified | UNKNOWN | Lateral Rectus Muscle and Anterior Segment Optical Coherence Tomography (AS-OCT) in Two Recession Surgeries |
| NCT02466659 | Not specified | TERMINATED | Controlled Intermittent Alternate Occlusion (CIAO) Therapy for Intermittent Exotropia |
| NCT02570555 | Not specified | COMPLETED | Strabismus Surgery and Driving Ability |
| NCT02699580 | Not specified | COMPLETED | Protective Effect of Biodegradable Collagen Implant (Ologen) in Scleral Thinning After Strabismus Surgery |
| NCT02807350 | Not specified | COMPLETED | Trial of Overminus Spectacle Therapy for Intermittent Exotropia |
| NCT02902887 | Not specified | UNKNOWN | Monitored Controlled Intermittent Alternate Occlusion (CIAO) Therapy for Intermittent Exotropia |
| NCT03119311 | Not specified | COMPLETED | A Novel Diagnostic Method for Exotropia Using Video-oculography |
| NCT03321838 | Not specified | UNKNOWN | Office Based Vergence and Accommodative Therapy and Intermittent Exotropia |
| NCT03641040 | Not specified | UNKNOWN | The Analysis of Ocular Deviations Between Dominant and Non-dominant Eye Using Video-oculography (VOG) in Intermittent Exotropia |
| NCT03661476 | Not specified | COMPLETED | The Effect of Oculo-Motor Exercises in Intermittent Exotropia |
| NCT03700632 | Not specified | UNKNOWN | Part-time Patch Therapy for Treatment of Intermittent Exotropia |
| NCT03952702 | Not specified | UNKNOWN | Overminus Lens Therapy in Intermittent |
| NCT04263103 | Not specified | UNKNOWN | A Training Software (SJ-RS-WL2015) Rehabilitating Intermittent Exotropia Binocular Functions |
| NCT04307160 | Not specified | UNKNOWN | Relationship of Age at Surgery to Surgical Outcome After Surgery for Intermittent Exotropia |
| NCT04744779 | Not specified | UNKNOWN | Office Based Vergence/Accommodative Therapy for the Treatment of Intermittent Exotropia |
| NCT04961021 | Not specified | COMPLETED | Management of Consecutive Exotropia |
| NCT05089422 | Not specified | UNKNOWN | Study of Clinical Types and Surgical Out Come of Pediatric Exotropia |
| NCT05234957 | Not specified | COMPLETED | Symmetric vs Asymmetric BLR Recession in Management of Basic IXT With Ocular Dominance |
| NCT05242510 | Not specified | TERMINATED | Evaluation of Exotropia After Patching the Eye or After Prism Adaptation |
| NCT05615519 | Not specified | UNKNOWN | Validation of a Smartphone-based Intelligent Diagnosis and Measurement for Strabismus |
| NCT05643456 | Not specified | COMPLETED | Surgery for Large Angle Exotropia Two Muscles Versus Three Muscles |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| BOTULINUM TOXIN TYPE A | 4 | 1 |
| SODIUM CHLORIDE | 4 | 1 |