Extragonadal germ cell tumor

Summary

Extragonadal germ cell tumor (MONDO:0018201) is a cancer (an umbrella term covering 6 Mondo subtypes) and 46 clinical trials. Top therapeutic interventions include ifosfamide, bleomycin sulfate, and cyclophosphamide anhydrous. A subtype of germ cell tumor — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Prevalence: 1-9 / 1 000 000 (Europe) [Orphanet-validated]
• Umbrella term: 6 Mondo subtypes
• Clinical trials: 46

Clinical features

Epidemiology

Prevalence records

1 prevalence record(s), Orphanet:

Type	Class	Value	Geography	Validation
Annual incidence	1-9 / 1 000 000	0.13	Europe	Validated

Identifiers

Disease identifiers

Field	Value
Canonical name	extragonadal germ cell tumor
Mondo ID	MONDO:0018201
Orphanet	363579
NCIT	C3918
UMLS	C0262963
MedGen	75506
GARD	0009325
Is cancer (heuristic)	yes

Also known as: extragonadal germ cell neoplasm · extragonadal germ cell neoplasms · extragonadal germ cell tumor · neoplasm of extragonadal germ cell · neoplasm of the extragonadal germ cell · primary extragonadal germ cell tumor · primary extragonadal germ cell tumour · tumor of extragonadal germ cell · tumor of the extragonadal germ cell · tumour of extragonadal germ cell · tumour of the extragonadal germ cell

Disease family

This is a subtype of germ cell tumor. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › germ cell tumor › extragonadal germ cell tumor

Related subtypes (12): fallopian tube germ cell tumor, retroperitoneal germ cell neoplasm, childhood germ cell tumor, choriocarcinoma, malignant germ cell tumor, ovarian germ cell tumor, gonadal germ cell tumor, germinomatous germ cell tumor, germ cell tumor of the vulva, nongerminomatous germ cell tumor, adult germ cell tumor, germ cell benign neoplasm

Subtypes (6): central nervous system germ cell tumor, extragonadal germ cell cancer, extragonadal non-dysgerminomatous germ cell tumor, cardiac germ cell tumor, mediastinal germ cell tumor, lung germ cell tumor

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 46.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE2	20
PHASE3	7
PHASE1	7
Not specified	6
PHASE1/PHASE2	5
PHASE2/PHASE3	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00002566	PHASE3	COMPLETED	Combination Chemotherapy With Bone Marrow Transplantation in Treating Men With Germ Cell Tumors
NCT00002596	PHASE3	COMPLETED	Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors
NCT00003643	PHASE2/PHASE3	UNKNOWN	Combination Chemotherapy in Treating Men With Germ Cell Cancer
NCT00005590	PHASE3	COMPLETED	Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma
NCT00072215	PHASE3	TERMINATED	Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors
NCT00104676	PHASE3	COMPLETED	Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors
NCT00274950	PHASE3	UNKNOWN	Observation and/or Combination Chemotherapy After Surgery or Biopsy in Treating Young Patients With Extracranial Germ Cell Tumors
NCT00716976	PHASE3	COMPLETED	Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy
NCT00002472	PHASE2	COMPLETED	Cisplatin and Etoposide Prior to Radiation Therapy in Treating Patients With CNS Tumors
NCT00002489	PHASE2	COMPLETED	Combination Chemotherapy in Treating Children With Non-testicular Malignant Germ Cell Tumors
NCT00002508	PHASE1/PHASE2	COMPLETED	Combination Chemotherapy Followed by Bone Marrow or Stem Cell Transplantation in Treating Patients With Relapsed or Refractory Germ Cell Tumors
NCT00002515	PHASE2	COMPLETED	Combination Chemotherapy Followed by Bone Marrow Transplantation in Treating Patients With Rare Cancer
NCT00002558	PHASE1/PHASE2	COMPLETED	Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Germ Cell Tumors
NCT00002903	PHASE2	COMPLETED	Docetaxel in Treating Patients With Recurrent or Refractory Germ Cell Cancer
NCT00002931	PHASE2	COMPLETED	Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer
NCT00002943	PHASE2	COMPLETED	Carboplatin, Etoposide, Cyclophosphamide, and Autologous Bone Marrow Transplantation in Patients With Relapsed or Refractory Cancer
NCT00003173	PHASE2	COMPLETED	High-Dose Thiotepa Plus Peripheral Stem Cell Transplantation in Treating Patients With Refractory Solid Tumors
NCT00003657	PHASE2	COMPLETED	High-dose ICE With Amifostine
NCT00003811	PHASE2	COMPLETED	Combination Chemotherapy Plus Amifostine in Treating Children With Malignant Germ Cell Tumors
NCT00003852	PHASE2	TERMINATED	Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Germ Cell Tumors
NCT00024258	PHASE2	COMPLETED	Arsenic Trioxide in Treating Patients With Advanced Neuroblastoma or Other Childhood Solid Tumors
NCT00036842	PHASE2	COMPLETED	Arsenic Trioxide in Treating Men With Germ Cell Cancer
NCT00070096	PHASE2	COMPLETED	Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors
NCT00301782	PHASE2	COMPLETED	Combination Chemotherapy in Treating Male Patients With Germ Cell Tumors
NCT00423852	PHASE1/PHASE2	COMPLETED	Paclitaxel, Ifosfamide, and Carboplatin Followed By Autologous Stem Cell Transplant in Treating Patients With Germ Cell Tumors That Did Not Respond to Cisplatin
NCT00453232	PHASE2	COMPLETED	Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors
NCT00453310	PHASE2	COMPLETED	Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment
NCT00470366	PHASE2	COMPLETED	Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors
NCT00551122	PHASE1/PHASE2	UNKNOWN	Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors
NCT00788125	PHASE1/PHASE2	TERMINATED	Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors
NCT01037790	PHASE2	COMPLETED	Phase II Trial of the Cyclin-Dependent Kinase Inhibitor PD 0332991 in Patients With Cancer
NCT01172912	PHASE2	UNKNOWN	High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy
NCT06940804	PHASE2	WITHDRAWN	A Clinical Study Investigating the Therapeutic Effects and Safety of an Investigational Cell Therapy Given With and Without an Additional Investigational Product in Males With Testicular Cancer or a Form of Cancer That Developed From Sperm
NCT00002750	PHASE1	COMPLETED	Melphalan in Patients With Neoplastic Meningitis
NCT00007813	PHASE1	COMPLETED	Peripheral Stem Cell Transplantation Plus Chemotherapy in Treating Patients With Malignant Solid Tumors
NCT00020150	PHASE1	COMPLETED	Temozolomide and O6-benzylguanine in Treating Children With Solid Tumors
NCT00030108	PHASE1	COMPLETED	Ixabepilone in Treating Young Patients With Solid Tumors or Leukemia That Haven’t Responded to Therapy
NCT00036959	PHASE1	COMPLETED	ABT-751 in Treating Young Patients With Refractory Solid Tumors
NCT00313599	PHASE1	COMPLETED	Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors
NCT00638898	PHASE1	COMPLETED	Busulfan, Melphalan, Topotecan Hydrochloride, and a Stem Cell Transplant in Treating Patients With Newly Diagnosed or Relapsed Solid Tumor

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
IFOSFAMIDE	4	13
BLEOMYCIN SULFATE	4	9
CYCLOPHOSPHAMIDE ANHYDROUS	4	6
VINBLASTINE	4	4
CISPLATIN	4	3
ETOPOSIDE	4	3
THIOTEPA	4	3
AMIFOSTINE	4	2
ARSENIC TRIOXIDE	4	2
CARBOPLATIN	4	2
DASATINIB ANHYDROUS	4	2
ETOPOSIDE PHOSPHATE	4	2
FILGRASTIM	4	2
IXABEPILONE	4	2
LEVOFLOXACIN ANHYDROUS	4	2
MELPHALAN	4	2
DACTINOMYCIN	4	1
EPIRUBICIN HYDROCHLORIDE	4	1
LENOGRASTIM	4	1
OFLOXACIN	4	1
OXALIPLATIN	4	1
PACLITAXEL	4	1
PALBOCICLIB	4	1
SODIUM THIOSULFATE	4	1
SUNITINIB MALATE	4	1
TOPOTECAN HYDROCHLORIDE	4	1
6-O-BENZYLGUANINE	3	1
ABT-751	2	1
CHEMBL376464	0	2
CHEMBL48	0	1