Extrahepatic cholestasis

Summary

Extrahepatic cholestasis (MONDO:0006757) is a disease and 3 clinical trials. A subtype of cholestasis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 3

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	extrahepatic cholestasis
Mondo ID	MONDO:0006757
EFO	EFO:1000933
MeSH	D001651
DOID	DOID:13619
SNOMED CT	8262006
UMLS	C0005398
MedGen	2241
MedDRA	10008637
Anatomy (UBERON)	UBERON:0003703
Is cancer (heuristic)	no

Also known as: cholestasis of extrahepatic bile duct · extrahepatic bile duct cholestasis · extrahepatic cholestasis (finding)

Disease family

This is a subtype of cholestasis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › digestive system disorder › hepatobiliary disorder › biliary tract disorder › bile duct disorder › cholestasis › extrahepatic cholestasis

Related subtypes (4): obstructive jaundice, biliary atresia, intrahepatic cholestasis, parenteral nutrition-associated cholestasis

Subtypes (1): Mirizzi syndrome

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 3.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	3

Top trials by phase / activity

NCT	Phase	Status	Title
NCT03237247	Not specified	COMPLETED	Role of Complete Blood Picture in Predicting the Etiology of Extrahepatic Cholestasis
NCT04992585	Not specified	COMPLETED	Primary Versus Secondary Metal Stent Implantation in PTBD
NCT05268731	Not specified	UNKNOWN	Clinical Success of Different Percutaneous Transhepatic Biliary Drainage Procedures