Extraosseous osteosarcoma
diseaseOn this page
Also known as extraskeletal osteogenic sarcomaextraskeletal osteosarcomaosteosarcoma, extraskeletal, malignantsoft tissue osteosarcoma
Summary
Extraosseous osteosarcoma (MONDO:0002621) is a disease (an umbrella term covering 7 Mondo subtypes) and 2 clinical trials. Top therapeutic interventions include pazopanib and ifosfamide. A subtype of osteosarcoma — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Umbrella term: 7 Mondo subtypes
- Clinical trials: 2
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | extraosseous osteosarcoma |
| Mondo ID | MONDO:0002621 |
| DOID | DOID:3357 |
| NCIT | C8810 |
| SNOMED CT | 404077005 |
| UMLS | C0855052 |
| MedGen | 163186 |
| GARD | 0023192 |
| Is cancer (heuristic) | no |
Also known as: extraosseous osteosarcoma · extraskeletal osteogenic sarcoma · extraskeletal osteosarcoma · osteosarcoma, extraskeletal, malignant · soft tissue osteosarcoma
Data availability: 2 cell lines.
Disease family
This is a subtype of osteosarcoma. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › cancer › sarcoma › osteosarcoma › extraosseous osteosarcoma
Related subtypes (5): localized osteosarcoma, multifocal osteogenic sarcoma, pediatric osteosarcoma, bone osteosarcoma, low grade central osteosarcoma
Subtypes (7): kidney osteogenic sarcoma, mediastinal extraskeletal osteosarcoma, liver extraskeletal osteosarcoma, childhood extraosseous osteosarcoma, breast extraskeletal osteosarcoma, adult extraskeletal osteosarcoma, central nervous system extraskeletal osteosarcoma
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 2.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| PHASE2/PHASE3 | 1 |
| Not specified | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT02180867 | PHASE2/PHASE3 | ACTIVE_NOT_RECRUITING | Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery |
| NCT05515068 | Not specified | NOT_YET_RECRUITING | Registry For Children, Adolescents And Adults With Osteosarcoma And Biologically Related Bone Sarcomas |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| PAZOPANIB | 4 | 3 |
| IFOSFAMIDE | 4 | 1 |
| CHEMBL4068768 | 0 | 1 |
| CHEMBL4171277 | 0 | 1 |
Related Atlas pages
- Drugs: Pazopanib, Ifosfamide