factor VII and Factor VIII, combined deficiency of

Summary

factor VII and Factor VIII, combined deficiency of (MONDO:0007595) is a disease. A subtype of inherited blood coagulation disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	factor VII and Factor VIII, combined deficiency of
Mondo ID	MONDO:0007595
MeSH	C565025
OMIM	134430
UMLS	C1851377
MedGen	341995
GARD	0024565
Is cancer (heuristic)	no

Also known as: factor VII and Factor VIII, combined deficiency of

Disease family

This is a subtype of inherited blood coagulation disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › hematologic disorder › blood coagulation disease › inherited blood coagulation disorder › factor VII and Factor VIII, combined deficiency of

Related subtypes (39): platelet-type bleeding disorder 16, hypoplasminogenemia, Ehlers-Danlos syndrome, fibronectinemic type, factor V and factor VIII, combined deficiency of, type 1, congenital factor V deficiency, congenital high-molecular-weight kininogen deficiency, congenital factor XII deficiency, alpha-2-plasmin inhibitor deficiency, Scott syndrome, Tatsumi factor deficiency, congenital thrombotic thrombocytopenic purpura, Wiskott-Aldrich syndrome, hemophilia A, hemophilia B, hereditary thrombocytopenia and hematologic cancer predisposition syndrome, platelet-type bleeding disorder 12, platelet-type bleeding disorder 10, platelet-type bleeding disorder 8, hypercoagulability syndrome due to glycosylphosphatidylinositol deficiency, congenital factor XI deficiency, inherited prekallikrein deficiency, factor XIII, A subunit, deficiency of, factor XIII, b subunit, deficiency of, congenital plasminogen activator inhibitor type 1 deficiency, factor 5 and Factor VIII, combined deficiency of, 2, platelet-type bleeding disorder 14, platelet-type bleeding disorder 18, congenital vitamin K-dependent coagulation factors deficiency, hereditary thrombocytosis with transverse limb defect, familial thrombomodulin anomalies, cytosolic phospholipase-A2 alpha deficiency associated bleeding disorder, Hermansky-Pudlak syndrome, hereditary von Willebrand disease, inherited thrombophilia, Glanzmann thrombasthenia, plasminogen deficiency, type II, dysplasminogenemia, hereditary hemolytic uremic syndrome, hepatic fibrinogen storage disease

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.