Fasciitis

Summary

Fasciitis (MONDO:0004830) is a disease (an umbrella term covering 6 Mondo subtypes) and 5 clinical trials. Top therapeutic interventions include glasdegib and methotrexate. A subtype of musculoskeletal system disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Umbrella term: 6 Mondo subtypes
• Clinical trials: 5

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	fasciitis
Mondo ID	MONDO:0004830
MeSH	D005208
DOID	DOID:9598
NCIT	C50559
SNOMED CT	36948007
UMLS	C0015645
MedGen	4658
Is cancer (heuristic)	no

Also known as: fascia inflammation · fasciitis · fasciitis (disease) · Fascitis · inflammation of fascia

Data availability: 1 HPO phenotype.

Disease family

This is a subtype of musculoskeletal system disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › fasciitis

Related subtypes (21): autoimmune disorder of musculoskeletal system, musculoskeletal system benign neoplasm, musculoskeletal system cancer, Klippel-Feil syndrome, enthesopathy, muscle tissue disorder, skeletal system disorder, synovial chondromatosis, auriculoosteodysplasia, hypertrophic osteoarthropathy, primary, autosomal dominant, Upington disease, Ramon syndrome, osteoporosis-oculocutaneous hypopigmentation syndrome, short stature, Brussels type, wormian bone-multiple fractures-dentinogenesis imperfecta-skeletal dysplasia, CINCA syndrome, chondrodysplasia with joint dislocations, gPAPP type, ligament disorder, synovium disorder, disease of the tendon, Short stature, Dauber-Argente type

Subtypes (6): nodular fasciitis, proliferative fasciitis, plantar fasciitis, ischemic fasciitis, necrotizing fasciitis, eosinophilic fasciitis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 5.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	4
PHASE1/PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT04111497	PHASE1/PHASE2	TERMINATED	Glasdegib for Chronic Graft-Versus-Host Disease
NCT07471035	Not specified	NOT_YET_RECRUITING	Focused Shockwave Therapy for Plantar Fasciopathy
NCT00382941	Not specified	COMPLETED	Study of LED Phototherapy for Musculoligamentous Lesions
NCT00441961	Not specified	COMPLETED	Treatment With High Dose Methotrexate in Patients With Eosinophilic Fasciitis
NCT01363375	Not specified	UNKNOWN	Effects of Different Foot Structures on Plantar Fasciitis and Therapeutic Footwear Intervention

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
GLASDEGIB	4	1
METHOTREXATE	4	1