Female infertility of uterine origin

Summary

Female infertility of uterine origin (MONDO:0001753) is a disease and 2 clinical trials. Top therapeutic interventions include estradiol and estrogen. A subtype of uterine disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 2

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	female infertility of uterine origin
Mondo ID	MONDO:0001753
DOID	DOID:13589
ICD-10-CM	N97.2
SNOMED CT	26899006
UMLS	C0156416
MedGen	510285
Is cancer (heuristic)	no

Also known as: infertility, female, of uterine origin

Disease family

This is a subtype of uterine disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › reproductive system disorder › female reproductive system disorder › uterine disorder › female infertility of uterine origin

Related subtypes (20): pyometritis, endometrial disorder, uterine inflammatory disease, chronic subinvolution of uterus, adhesions of uterus, cervix disorder, uterine polyp, pelvic congestion syndrome, uterine inversion, placenta disorder, hemometra, parametritis, cordiform uterus, septate uterus, bicornuate uterus, uterine hypoplasia, agenesis and aplasia of uterine body, tumor of uterus, florid cystic endosalpingiosis of the uterus, pregnancy, cornual

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 2.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE1/PHASE2	1
Not specified	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT04233892	PHASE1/PHASE2	UNKNOWN	Clinical Study of in Situ Regeneration of Endometrium
NCT03307356	Not specified	ACTIVE_NOT_RECRUITING	The University of Pennsylvania Uterus Transplant for Uterine Factor Infertility Trial

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
ESTRADIOL	4	1
ESTROGEN	3	1