Female reproductive system neoplasm
diseaseOn this page
Also known as female reproductive organ neoplasm (disease)female reproductive organ tumorfemale reproductive organ tumourfemale reproductive system neoplasm (disease)female reproductive system tumorfemale reproductive system tumourgynecologic neoplasmgynecologic tumorgynecologic tumourneoplasm of female reproductive organneoplasm of female reproductive systemneoplasm of the female reproductive systemtumor of female reproductive systemtumor of the female reproductive systemtumour of female reproductive systemtumour of the female reproductive system
Summary
Female reproductive system neoplasm (MONDO:0021148) is a cancer (an umbrella term covering 11 Mondo subtypes) and 33 clinical trials. Top therapeutic interventions include argatroban, carboplatin, and dimenhydrinate. A subtype of female reproductive system disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Classification: Cancer
- Umbrella term: 11 Mondo subtypes
- Clinical trials: 33
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | female reproductive system neoplasm |
| Mondo ID | MONDO:0021148 |
| MeSH | D005833 |
| NCIT | C3053 |
| UMLS | C0017416 |
| MedGen | 9004 |
| Anatomy (UBERON) | UBERON:0000474 |
| Is cancer (heuristic) | yes |
Also known as: female reproductive organ neoplasm (disease) · female reproductive organ tumor · female reproductive organ tumour · female reproductive system neoplasm · female reproductive system neoplasm (disease) · female reproductive system tumor · female reproductive system tumour · gynecologic neoplasm · gynecologic tumor · gynecologic tumour · neoplasm of female reproductive organ · neoplasm of female reproductive system · neoplasm of the female reproductive system · tumor of female reproductive system · tumor of the female reproductive system · tumour of female reproductive system · tumour of the female reproductive system
Disease family
This is a subtype of female reproductive system disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › reproductive system disorder › female reproductive system disorder › female reproductive system neoplasm
Related subtypes (33): ectopic pregnancy, pelvic inflammatory disease, endosalpingiosis, vaginal disorder, prolapse of female genital organ, Allen-Masters syndrome, fallopian tube disorder, vulvar disease, uterine disorder, gynatresia, Bartholin duct cyst, ovarian disorder, hymen, imperforate, preterm premature rupture of the membranes, mammary-digital-nail syndrome, Asherman syndrome, uterine cervical aplasia and agenesis, longitudinal vaginal septum, transverse vaginal septum, polycystic ovaries-urethral sphincter dysfunction syndrome, granulomatous mastitis, vaginal atresia, mullerian aplasia, vulvovaginal gingival syndrome, isolated partial vaginal agenesis, female infertility, polyp of vulva, vulval varices, vulvodynia, menstrual cycle-dependent periodic fever, Bartholin’s gland disease, delayed puberty, self-limited, menstrual disorder
Subtypes (11): benign female reproductive system neoplasm, female reproductive organ cancer, endometrioid tumor, endometrioid stromal and related neoplasms of the cervix, gestational trophoblastic neoplasm, vulvar neoplasm, vaginal neoplasm, ovarian neoplasm, fallopian tube neoplasm, tumor of uterus, endometrioid stromal and related neoplasms
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
Drugs indicated for this disease
0 approved, 5 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.
| Drug | Development status |
|---|---|
| Ferric Carboxymaltose | Phase 3 (in late-stage trials) |
| Heparin | Phase 3 (in late-stage trials) |
| Paclitaxel | Phase 3 (in late-stage trials) |
| Prasterone | Phase 3 (in late-stage trials) |
| Tranexamic Acid | Phase 3 (in late-stage trials) |
Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Avutometinib, Defactinib, Pembrolizumab.
Clinical trials & evidence
Clinical trials
Clinical trials: 33.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 22 |
| PHASE3 | 3 |
| PHASE2 | 3 |
| PHASE1 | 3 |
| PHASE1/PHASE2 | 1 |
| EARLY_PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00328757 | PHASE3 | WITHDRAWN | Safety of Regular Diet as the First Meal in Patients Who Underwent Surgical Treatment for Gynecologic Cancer |
| NCT02935530 | PHASE3 | COMPLETED | Thromboprophylaxis After Surgery for Gynecologic Malignancy in China |
| NCT03740633 | PHASE3 | UNKNOWN | Functional Training for the Prevention of Deep Venous Thrombosis |
| NCT04969887 | PHASE2 | ACTIVE_NOT_RECRUITING | Combination Immunotherapy in Rare Cancers Under InvesTigation |
| NCT05979610 | PHASE2 | RECRUITING | Using Reiki Therapy to Improve Symptoms Associated With Brachytherapy in Patients With Gynecological Malignancies |
| NCT04493619 | PHASE1/PHASE2 | TERMINATED | PLX2853 as a Single Agent in Advanced Gynecological Malignancies and in Combination With Carboplatin in Platinum-Resistant Epithelial Ovarian Cancer |
| NCT05185947 | PHASE2 | COMPLETED | Intravenous and Intraperitoneal Paclitaxel and Oral Nilotinib for Peritoneal Carcinomatosis |
| NCT07038369 | PHASE1 | ACTIVE_NOT_RECRUITING | A Phase 1 Study of ATV-1601 in Patients With Advanced Cancer That Have AKT1 E17K Mutations |
| NCT00800345 | PHASE1 | COMPLETED | Phase I Trial of Oral Metronomic Topotecan and Oral Pazopanib to Treat Recurrent/Persistent Gynecologic Tumors |
| NCT03101280 | PHASE1 | COMPLETED | A Combination Study of Rucaparib and Atezolizumab in Participants With Advanced Gynecologic Cancers and Triple-Negative Breast Cancer |
| NCT02728830 | EARLY_PHASE1 | COMPLETED | A Study of Pembrolizumab on the Tumoral Immunoprofile of Gynecologic Cancers |
| NCT03141437 | Not specified | ACTIVE_NOT_RECRUITING | Decision Aid Website in Helping to Make Decisions About Fertility in Participants With Cancer |
| NCT04075305 | Not specified | RECRUITING | The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study |
| NCT05053230 | Not specified | RECRUITING | A Study Evaluating the Integrative Medicine at Home (IM@HOME) Program in People With Cancer |
| NCT05242861 | Not specified | RECRUITING | Retrospective Study of Brachytherapy |
| NCT06018935 | Not specified | RECRUITING | A Cohort Establishment Study of Total Management of Ovarian Cancer |
| NCT06089083 | Not specified | RECRUITING | PROmOting Gynecologic Cancer Patients With Frailty to Achieve Functional Recovery |
| NCT07267780 | Not specified | NOT_YET_RECRUITING | Contribution of Oncovascular Surgery in the Treatment of Gynecological Advanced Malignant Diseases. |
| NCT07280312 | Not specified | RECRUITING | Ultrasound Microvessel Imaging for the Evaluation of Ovarian and Adnexal Lesions |
| NCT02309944 | Not specified | COMPLETED | Negative Pressure Wound Therapy in Obese Gynecologic Oncology Patients |
| NCT02653469 | Not specified | COMPLETED | Augmented Pulse Pressure Variation to Predict Fluid Responsiveness in Open Laparotomy |
| NCT02786524 | Not specified | COMPLETED | Effect of Outpatient Symptom Management on Gynecologic Oncology Patients Receiving Chemotherapy |
| NCT02918461 | Not specified | COMPLETED | Emerging From the Haze for Gynecologic Cancer Survivors |
| NCT03142477 | Not specified | UNKNOWN | Effects of Therapeutic Touch in Patients With Female Genital Neoplasia: a Randomized Controlled Clinical Trial |
| NCT03379376 | Not specified | COMPLETED | EHealth Mindful Movement and Breathing in Improving Outcomes in Participants Undergoing Gynecologic Surgery |
| NCT03993210 | Not specified | TERMINATED | The Value of Advanced MR Imaging in Gynecological Tumors and Benign Uterine Fibroids |
| NCT04122235 | Not specified | COMPLETED | The Lifestyle and Empowerment Techniques in Survivorship of Gynecologic Oncology Study |
| NCT04626895 | Not specified | COMPLETED | Efficacy of Paxman Scalp Cooling to Prevent Chemo Induced Alopecia in Black Patients With Breast or GYN Cancers |
| NCT04945187 | Not specified | UNKNOWN | Patient-Reported Outcomes Among Women Wtih Gynecological Cancer (The CONNECT Study) |
| NCT05738902 | Not specified | UNKNOWN | Adherence and Compliance to ERAS in Gynecological Surgery |
| NCT06395064 | Not specified | UNKNOWN | The Effect of Dimenhydrinate on Postoperative Nausea and Vomiting After Abdominal Hysterectomy: Randomized-controlled Trial |
| NCT07036549 | Not specified | COMPLETED | Impact of Preoperative Sleep Quality and Anxiety on Postoperative Outcomes in Abdominal Gynecologic Cancer Surgery |
| NCT07226102 | Not specified | WITHDRAWN | Virtual Mental Health Intervention to Address Fear of Progression for Women With High Risk or Stage III-IV Gynecologic or Breast Cancer |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| ARGATROBAN | 4 | 1 |
| CARBOPLATIN | 4 | 1 |
| DIMENHYDRINATE | 4 | 1 |
| RUCAPARIB | 4 | 1 |
| CHEMBL502016 | 0 | 1 |
| CHEMBL59461 | 0 | 1 |
| CHEMBL454299 | 0 | 1 |
Related Atlas pages
- Drugs: Argatroban, Carboplatin, Dimenhydrinate, Rucaparib