Femoral neck fracture
diseaseOn this page
Also known as bone fracture of neck of femurfemur neck fracturefemur neck fracturesfracture of neck of femurneck of femur bone fracture
Summary
Femoral neck fracture (MONDO:0043589) is a disease and 169 clinical trials. Top therapeutic interventions include ropivacaine, bupivacaine, and calcium. A subtype of hip fracture — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 169
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | femoral neck fracture |
| Mondo ID | MONDO:0043589 |
| MeSH | D005265 |
| SNOMED CT | 5913000 |
| Anatomy (UBERON) | UBERON:0007119 |
| Is cancer (heuristic) | no |
Also known as: bone fracture of neck of femur · femoral neck fracture · femur neck fracture · femur neck fractures · fracture of neck of femur · neck of femur bone fracture
Disease family
This is a subtype of hip fracture. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: injury › bone fracture › hip fracture › femoral neck fracture
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
Drugs indicated for this disease
0 approved, 2 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.
| Drug | Development status |
|---|---|
| Ergocalciferol | Phase 3 (in late-stage trials) |
| Tranexamic Acid | Phase 3 (in late-stage trials) |
Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Bupivacaine.
Clinical trials & evidence
Clinical trials
Clinical trials: 169.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 139 |
| PHASE4 | 19 |
| PHASE3 | 7 |
| PHASE2/PHASE3 | 1 |
| PHASE2 | 1 |
| PHASE1/PHASE2 | 1 |
| PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT05023369 | PHASE4 | RECRUITING | This is a Study to Verify if Periarticular Hip Injection of Corticosteroid After Hip Replacement Reduce the Pain and the Hospitalisation Time |
| NCT06565910 | PHASE4 | RECRUITING | Bupivacaine Liposome Plus Bupivacaine or Ropivacaine for Pericapsular Nerve Group Block in Hip Arthroplasty (PENG) |
| NCT07130006 | PHASE4 | NOT_YET_RECRUITING | Preoperative Use of Peripheral Nerve Blocks in Elderly Patients With Hip Fractures |
| NCT00464230 | PHASE4 | COMPLETED | Hemiarthroplasty or Internal Fixation for Displaced Femoral Neck Fractures |
| NCT00529425 | PHASE4 | COMPLETED | Postoperative Analgesia With Local Infiltration After Femoral Neck Fracture |
| NCT00829725 | PHASE4 | UNKNOWN | Comparison Study of 3-4-screws-internal Fixation With Multi-screw-system Targon FN for Femoral Neck Fracture |
| NCT00926666 | PHASE4 | UNKNOWN | A Dose Finding Study for Pain Relief of a Broken Hip |
| NCT01005550 | PHASE4 | COMPLETED | Ropivacaine Hypobaric Spinal Anaesthesia in Traumatic Hip Surgery |
| NCT01052974 | PHASE4 | COMPLETED | Perioperative Analgesia by Femoral Perineural Catheter for Femoral Neck Fracture - Study KTcol |
| NCT01112436 | PHASE4 | UNKNOWN | The Effect of Periarticular Multi-Drug Regimen on Pain After Partial Hip Replacement |
| NCT01219062 | PHASE4 | TERMINATED | Postoperative Pain Control After Hip Hemiarthroplasty: Intrathecal Morphine vs Periarticular Infiltration of Bupivacaine |
| NCT01219088 | PHASE4 | UNKNOWN | Intrathecal Morphine,Femoral Nerve Block,Periarticular Bupivacaine Infiltration for Pain After Intramedullary Hip Screw |
| NCT01408693 | PHASE4 | COMPLETED | Minimal Invasive Anterior Approach Versus Trans-gluteal Approach for Hemi-arthroplasty in Femoral Neck Fractures |
| NCT01934049 | PHASE4 | UNKNOWN | Postoperative Recovery in Elderly Patients Undergoing Hip Hemi-arthroplasty |
| NCT02148848 | PHASE4 | UNKNOWN | Short-term Functional Recovery Between Early- and Late Bisphosphonate Treatment Following Hemiarthroplasty |
| NCT02379663 | PHASE4 | COMPLETED | Prophylaxis of Deep Vein Thrombosis Following Total Hip Arthroplasty |
| NCT02433548 | PHASE4 | COMPLETED | Fascia Iliaca Block in the Emergency Department for Analgesia After Femoral Neck Fracture |
| NCT02664909 | PHASE4 | COMPLETED | Topical (Intra-Articular) Tranexamic Acid and Transfusion Rates Following Hip Hemiarthroplasty |
| NCT03502018 | PHASE4 | COMPLETED | Hip Fracture Exparel Administration Trial Capsule During Hemiarthroplasty |
| NCT05164081 | PHASE3 | ACTIVE_NOT_RECRUITING | Dual vs. Single-Antibiotic Impregnated Cement in Hemiarthroplasty for Femoral Neck Fracture |
| NCT00307905 | PHASE3 | WITHDRAWN | TRAUMEEL for Pain After Fracture of Neck of Femur |
| NCT01473589 | PHASE3 | COMPLETED | Effect of Teriparatide on Hip Fracture Healing |
| NCT01473602 | PHASE3 | COMPLETED | Second Study of the Effect of Teriparatide on Hip Fracture Healing |
| NCT01727843 | PHASE3 | TERMINATED | Topical Application of Tranexamic Acid and Postoperative Blood Loss in Femoral Neck Fractures |
| NCT01798472 | PHASE2/PHASE3 | UNKNOWN | Hip Fractures Treated With Uncemented Arthroplasties |
| NCT01908751 | PHASE3 | TERMINATED | Fixation Using Alternative Implants for the Treatment of Hip Fractures (FAITH-2) |
| NCT04408053 | PHASE3 | UNKNOWN | Mini-invasive Preventive Fixation of the Contralateral Femoral Neck in Patients Operated on for a Femoral Neck Fracture |
| NCT01701414 | PHASE2 | COMPLETED | Ultrasound-guided Femoral Nerve Blocks in Elderly Patients With Hip Fractures |
| NCT02630836 | PHASE1/PHASE2 | WITHDRAWN | Allogeneic Mesenchymal Stromal Cells in Elderly Patients With Hip Fracture |
| NCT01109862 | PHASE1 | UNKNOWN | Prospective Randomized Comparison of Bipolar Hemiarthroplasty and Total Hip Arthroplasty With Large Femoral Heads for the Treatment of Displaced Intracapsular Femoral Neck Fractures in the Elderly |
| NCT02362971 | Not specified | ACTIVE_NOT_RECRUITING | External Validity of a Randomized Trial in Patients With a Femoral Neck Fracture |
| NCT03266874 | Not specified | ACTIVE_NOT_RECRUITING | G7 BiSpherical Acetabular Shell PMCF Study |
| NCT03357445 | Not specified | ACTIVE_NOT_RECRUITING | AVANTAGE® RELOAD Double Mobility Acetabular Cup -Clinical Study |
| NCT03396224 | Not specified | ACTIVE_NOT_RECRUITING | Avenir® Cemented Hip Stem - PMCF |
| NCT03966716 | Not specified | RECRUITING | Hips Screws or (Total) Hip Replacement for Undisplaced Femoral Neck Fractures in Elderly Patients (HipSTHeR) |
| NCT04349046 | Not specified | ACTIVE_NOT_RECRUITING | Exception Cementless Hip Stem |
| NCT04589598 | Not specified | ACTIVE_NOT_RECRUITING | Femoral Neck System and Multiple Cannulated Screws in Femoral Neck Fracture |
| NCT04869332 | Not specified | RECRUITING | Three Cancellous Screws Versus Four Cancellous Screws for Femoral Neck Fixation |
| NCT04900506 | Not specified | ACTIVE_NOT_RECRUITING | Surgical Approach in Hemiarthroplasty. A Randomized Clinical Trial Comparing Posterior and Anterior Approach |
| NCT05144191 | Not specified | ACTIVE_NOT_RECRUITING | Insignia™ Hip Stem Outcomes Study |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| ROPIVACAINE | 4 | 5 |
| BUPIVACAINE | 4 | 2 |
| CALCIUM | 4 | 2 |
| MORPHINE | 4 | 2 |
| TERIPARATIDE | 4 | 2 |
| ENOXAPARIN SODIUM | 4 | 1 |
| LEVOBUPIVACAINE | 4 | 1 |
| RISEDRONIC ACID | 4 | 1 |
| RIVAROXABAN | 4 | 1 |
| TRANEXAMIC ACID | 4 | 1 |
| CIPEPOFOL | 3 | 1 |
| CHEMBL4589226 | 0 | 2 |
| CHEMBL5072826 | 0 | 2 |
| CHEMBL443232 | 0 | 1 |
| ENOXAPARIN | 0 | 1 |