Fetal alcohol spectrum disorder
disease diseaseOn this page
Also known as alcohol related birth defectsalcohol related neurodevelopmental disorderalcohol-related birth defectsalcohol-related birth defects (ARBD) - typealcohol-related neurodevelopmental disorder (ARND) - typebirth defects, alcohol-relatedFAE (fetal alcohol effects)FAEs (fetal alcohol effects)FASDFASDsfetal alcohol spectrum disordersfetal alcohol syndromefetal alcohol syndrome (FAS) - typefoetal alcohol spectrum disordersfoetal alcohol syndromefoetal alcohol syndrome (FAS) - typegrowth retardation, facial abnormalities, and central nervous system dysfunctionpartial fetal alcohol syndromepartial foetal alcohol syndromesyndrome, fetal alcohol
Summary
Fetal alcohol spectrum disorder (MONDO:0000408) is a disease and 60 clinical trials. Top therapeutic interventions include atomoxetine, methylphenidate, and choline. A subtype of specific developmental disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 60
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | fetal alcohol spectrum disorder |
| Mondo ID | MONDO:0000408 |
| MeSH | D063647 |
| DOID | DOID:0050696 |
| NCIT | C92780 |
| SNOMED CT | 609437000 |
| UMLS | C2985290 |
| MedGen | 457516 |
| Is cancer (heuristic) | no |
Also known as: alcohol related birth defects · alcohol related neurodevelopmental disorder · alcohol-related birth defects · alcohol-related birth defects (ARBD) - type · alcohol-related neurodevelopmental disorder (ARND) - type · birth defects, alcohol-related · FAE (fetal alcohol effects) · FAEs (fetal alcohol effects) · FASD · FASDs · fetal alcohol spectrum disorders · fetal alcohol syndrome · fetal alcohol syndrome (FAS) - type · foetal alcohol spectrum disorders · foetal alcohol syndrome · foetal alcohol syndrome (FAS) - type · growth retardation, facial abnormalities, and central nervous system dysfunction · partial fetal alcohol syndrome · partial foetal alcohol syndrome · syndrome, fetal alcohol (+1 more)
Disease family
This is a subtype of specific developmental disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by developmental or physiological process › psychiatric disorder › mental disorder › developmental disorder of mental health › specific developmental disorder › fetal alcohol spectrum disorder
Related subtypes (9): oppositional defiant disorder, fetal nicotine spectrum disorder, communication disorder, stereotypic movement disorder, tic disorder, learning disability, developmental coordination disorder, conduct disorder, attention deficit-hyperactivity disorder
Subtypes (4): partial fetal alcohol syndrome, alcohol-related birth defect, fetal alcohol syndrome, neurobehavioral disorder with prenatal alcohol exposure
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 60.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 46 |
| PHASE1/PHASE2 | 4 |
| PHASE2 | 4 |
| PHASE3 | 2 |
| PHASE1 | 2 |
| PHASE4 | 1 |
| EARLY_PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT04968522 | PHASE4 | UNKNOWN | FASST - Fetal Alcohol Spectrum Stimulant Trial |
| NCT00418262 | PHASE3 | COMPLETED | Open-Label Study of the Long Term Tolerability and Safety of Atomoxetine in Children With FASD and ADD/ADHD |
| NCT00996528 | PHASE3 | UNKNOWN | Neighborhood Alcohol & HIV Prevention in South African Townships (Philani) |
| NCT04395196 | PHASE2 | RECRUITING | RCT of Prenatal Choline Supplementation During Pregnancy to Mitigate Adverse Effects of Prenatal Alcohol Exposure |
| NCT05108974 | PHASE2 | ACTIVE_NOT_RECRUITING | Choline Supplementation as a Neurodevelopmental Intervention in Fetal Alcohol Spectrum Disorders Study |
| NCT00164229 | PHASE1/PHASE2 | COMPLETED | Fetal Alcohol Syndrome: Socio-Cognitive Habilitation |
| NCT00164346 | PHASE1/PHASE2 | COMPLETED | Neurocognitive Habilitation for Children With Fetal Alcohol Syndrome (FAS)/Alcohol-Related Neurodevelopmental Disorder (ARND) |
| NCT00164554 | PHASE1/PHASE2 | COMPLETED | Fetal Alcohol Syndrome/ARND Research Consortion |
| NCT01149538 | PHASE1/PHASE2 | COMPLETED | Postnatal Choline Supplementation in Children With Prenatal Alcohol Exposure |
| NCT01911299 | PHASE2 | COMPLETED | Choline Supplementation in Children With Fetal Alcohol Spectrum Disorders |
| NCT02735473 | PHASE2 | COMPLETED | Choline Supplementation as a Neurodevelopmental Intervention in Fetal Alcohol Spectrum Disorders |
| NCT06635746 | PHASE1 | NOT_YET_RECRUITING | Dose Escalation Study of Vinpocetine in Healthy Volunteers |
| NCT00417794 | PHASE1 | COMPLETED | Assess the Effectiveness of Atomoxetine in Children With Fetal Alcohol Syndrome and ADD/ADHD |
| NCT00747630 | EARLY_PHASE1 | TERMINATED | Evaluating the Efficacy of a Video Based Intervention to Educate Teen Moms About Fetal Alcohol Syndrome (FAS) |
| NCT03371641 | Not specified | RECRUITING | In Utero Alcoholic Exposure: PlGF, Biomarker of Fetal Brain Lesions |
| NCT05456321 | Not specified | RECRUITING | CIFASD 5 tDCS and Cognitive Training |
| NCT05534568 | Not specified | RECRUITING | The Oklahoma Parent-Child Assistance Program |
| NCT05686473 | Not specified | RECRUITING | Psychoeducation of Parents to Children With FASD |
| NCT05960461 | Not specified | RECRUITING | Families Moving Forward (FMF) Connect Pro for Mental Health Providers |
| NCT06005181 | Not specified | RECRUITING | The Synchrony Study: Examining Music Training for Children With FASD |
| NCT06638463 | Not specified | RECRUITING | My Health Coach App RCT |
| NCT06847165 | Not specified | RECRUITING | Trigeminal Nerve Stimulation for Children With Prenatal Alcohol Exposure |
| NCT06935461 | Not specified | ENROLLING_BY_INVITATION | Families Moving Forward Bridges: An Early Intervention for Infants and Toddlers With PAE With or At-risk for FASD |
| NCT07016009 | Not specified | RECRUITING | Thrive Person-Centered Planning Program for Young Adults With Fetal Alcohol Spectrum Disorders |
| NCT07547696 | Not specified | NOT_YET_RECRUITING | CARRII Native Intervention Optimization Trial |
| NCT00244062 | Not specified | COMPLETED | Healthy Moms Alcohol Intervention |
| NCT00696085 | Not specified | COMPLETED | Fetal Alcohol Damage Prevention Study |
| NCT01536184 | Not specified | COMPLETED | Evaluating the Effectiveness of an Attachment-Focused Intervention in Preschool Children With FASD |
| NCT01961050 | Not specified | COMPLETED | Preventing FAS/ARND in Russian Children |
| NCT01971398 | Not specified | COMPLETED | Development of Education Materials for Prevention of FAS in Russia |
| NCT01994603 | Not specified | COMPLETED | Expansion to Interdisciplinary HIV Prevention in Women |
| NCT02128880 | Not specified | COMPLETED | Contraception and Alcohol Risk Reduction Internet Intervention Randomized Trial |
| NCT02210455 | Not specified | COMPLETED | Parenting Training for Children With FASD |
| NCT02457676 | Not specified | COMPLETED | Improving Self Regulation in Children With Fetal Alcohol Syndrome Spectrum Disorders: A Neuroplastic Intervention |
| NCT02558933 | Not specified | COMPLETED | Epigallocatechin Gallate (EGCG) to Improve Cognitive Performance in Foetal Alcohol Syndrome (FAS) Children |
| NCT02600624 | Not specified | COMPLETED | Prenatal Alcohol Biomarker Study in Uruguay |
| NCT02912962 | Not specified | COMPLETED | Self-Regulation in Adolescents With FASD: The Efficacy of a Targeted Intervention |
| NCT03342495 | Not specified | COMPLETED | Evaluating Innovations in Transition From Pediatric to Adult Care - The Transition Navigator Trial |
| NCT03361293 | Not specified | COMPLETED | Cognitive Training and tDCS for Children With FASD |
| NCT03494738 | Not specified | UNKNOWN | Development of an Epigenetic Biomarker for Prediction of Fetal Alcohol Spectrum Disorder |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| ATOMOXETINE | 4 | 3 |
| METHYLPHENIDATE | 4 | 3 |
| CHOLINE | 4 | 1 |
| DEXTROAMPHETAMINE SULFATE | 4 | 1 |
| NICOTINE POLACRILEX | 4 | 1 |
| VINPOCETINE | 4 | 1 |
| CHOLINE BITARTRATE | 3 | 4 |
| EPIGALOCATECHIN GALLATE | 3 | 1 |
| CHEMBL1360725 | 0 | 1 |