Fixed pigmented erythema
disease diseaseOn this page
Also known as fixed drug eruption
Summary
Fixed pigmented erythema (MONDO:0017395) is a disease. A subtype of toxic dermatosis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Prevalence: Unknown (Worldwide) [Orphanet-validated]
- Phenotypes (HPO): 18
Clinical features
Signs & symptoms
Clinical features (HPO)
18 HPO clinical features (Orphanet curated; top 18 by frequency):
| HPO ID | Term | Frequency |
|---|---|---|
| HP:0010783 | Erythema | Very frequent (80-99%) |
| HP:0020172 | Adverse drug response | Very frequent (80-99%) |
| HP:0410323 | Drug allergy | Very frequent (80-99%) |
| HP:0011356 | Regional abnormality of skin | Frequent (30-79%) |
| HP:0025474 | Erythematous plaque | Frequent (30-79%) |
| HP:0003341 | Junctional split | Frequent (30-79%) |
| HP:0000953 | Hyperpigmentation of the skin | Occasional (5-29%) |
| HP:0000155 | Oral ulcer | Occasional (5-29%) |
| HP:0010280 | Stomatitis | Occasional (5-29%) |
| HP:0008066 | Abnormal blistering of the skin | Occasional (5-29%) |
| HP:0200041 | Skin erosion | Occasional (5-29%) |
| HP:0032156 | Skin detachment | Occasional (5-29%) |
| HP:0001945 | Fever | Occasional (5-29%) |
| HP:0012378 | Fatigue | Occasional (5-29%) |
| HP:0011354 | Generalized abnormality of skin | Very rare (<1-4%) |
| HP:0007473 | Crusting erythematous dermatitis | Very rare (<1-4%) |
| HP:0032565 | Vaginal mucosal ulceration | Very rare (<1-4%) |
| HP:0025143 | Chills | Very rare (<1-4%) |
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | fixed pigmented erythema |
| Mondo ID | MONDO:0017395 |
| Orphanet | 293812 |
| ICD-11 | 20014644 |
| SNOMED CT | 73692007 |
| UMLS | C0221242 |
| MedGen | 526203 |
| GARD | 0021170 |
| MedDRA | 10048796 |
| Is cancer (heuristic) | no |
Also known as: fixed drug eruption
Disease family
Classification path: disease › human disease › disease by body system or component › integumentary system disorder › skin disorder › toxic dermatosis › fixed pigmented erythema
Related subtypes (4): drug rash with eosinophilia and systemic symptoms, acute generalized exanthematous pustulosis, toxic epidermal necrolysis, erythema multiforme major
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 0.
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.