Food protein-induced enterocolitis syndrome

Summary

Food protein-induced enterocolitis syndrome (MONDO:0100008) is a disease and 8 clinical trials. A subtype of enterocolitis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 8

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	food protein-induced enterocolitis syndrome
Mondo ID	MONDO:0100008
ICD-10-CM	K52.21
ICD-11	1729235847
UMLS	C4268599
MedGen	1623554
Is cancer (heuristic)	no

Also known as: delayed food allergy · FPIES

Disease family

This is a subtype of enterocolitis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › disease of genetic or genomic mechanism › hereditary disease › enterocolitis › food protein-induced enterocolitis syndrome

Related subtypes (1): necrotizing enterocolitis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 8.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	8

Top trials by phase / activity

NCT	Phase	Status	Title
NCT05528900	Not specified	RECRUITING	A Multicentre French Prospective Study of Children With Food Protein Induced Enterocolitis Syndrome in Its Acute Form
NCT06614244	Not specified	NOT_YET_RECRUITING	Oral Immunotherapy for Food Protein Induced Enterocolitis Syndrome
NCT06683521	Not specified	RECRUITING	Immunologic Basis of Food Protein-Induced Enterocolitis Syndrome
NCT07592182	Not specified	NOT_YET_RECRUITING	Tolerance and Growth Outcomes of an Extensively Hydrolysed Anti-regurgitation Casein-based Formula in Infants With Cow’s Milk Protein Allergy
NCT04081415	Not specified	UNKNOWN	Longitudinal Study of the Intestinal, Cutaneous and Salivary Microbiota in Children With Food-induced Enterocolitis Syndrome (SEIPA)
NCT04462978	Not specified	UNKNOWN	Non-Immunoglobulin E-mediated Food Allergies in Children
NCT04643704	Not specified	COMPLETED	Quality of Life and Eating Disorders in Children With FPIES, Food Allergy or Celiac Disease
NCT04644783	Not specified	COMPLETED	Novel Blood Test to Predict Safe Foods for Infants and Toddlers With Food Protein-induced Enterocolitis Syndrome (FPIES)