Frey syndrome

Summary

Frey syndrome (MONDO:0007753) is a disease and 2 clinical trials. Top therapeutic interventions include zinc oxide, silver, and durapatite. A subtype of autonomic nervous system disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: Unknown (Worldwide) [Orphanet-validated]
• Clinical trials: 2

Clinical features

Epidemiology

Prevalence records

1 prevalence record(s), Orphanet:

Type	Class	Value	Geography	Validation
Cases/families		121	Worldwide	Validated

Identifiers

Disease identifiers

Field	Value
Canonical name	Frey syndrome
Mondo ID	MONDO:0007753
EFO	EFO:1000940
MeSH	D013547
OMIM	144100
Orphanet	662240
DOID	DOID:11599
SNOMED CT	238758008
UMLS	C0038994
MedGen	21041
GARD	0027052
Is cancer (heuristic)	no

Also known as: Baillarger syndrome · Frey syndrome · Frey’s syndrome · gustatory hyperhidrosis · gustatory sweating · hyperhidrosis gustatory · hyperhidrosis, gustatory · HYPRG

Disease family

This is a subtype of autonomic nervous system disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › nervous system disorder › central nervous system disorder › autonomic nervous system disorder › Frey syndrome

Related subtypes (12): idiopathic peripheral autonomic neuropathy, autonomic neuropathy, autonomic nervous system neoplasm, harlequin syndrome, chronic hiccup, pure autonomic failure, baroreflex failure, autonomic dysreflexia, dysautonomia, sympathetic nervous system disorder, parasympathetic nervous system disorder, central hypoventilation syndrome, congenital, 1, with or without Hirschsprung disease

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 2.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	2

Top trials by phase / activity

NCT	Phase	Status	Title
NCT05452837	Not specified	COMPLETED	FDFG Versus SMAS Flap After Superficial Parotidectomy; Evaluation of Functional and Esthetic Outcome
NCT05898724	Not specified	COMPLETED	Assessment of the Rate of Oseointegration Surrounding Nano-coated Orthodontic Titanium Miniscrew

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
ZINC OXIDE	4	1
SILVER	3	1
DURAPATITE	2	1