Frostbite

Summary

Frostbite (MONDO:0800177) is a disease and 8 clinical trials. Top therapeutic interventions include dalbavancin, oxygen, and aloe. A subtype of injury — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 8

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	frostbite
Mondo ID	MONDO:0800177
ICD-10-CM	T33-T34
ICD-11	152692065
NCIT	C34627
SNOMED CT	370977006
Is cancer (heuristic)	no

Disease family

This is a subtype of injury. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: injury › frostbite

Related subtypes (9): ischemia reperfusion injury, bone fracture, acute lung injury, spinal injury, radiation injury, burn, ankle injury, nervous system injury, head injury

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 8.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	5
PHASE4	3

Top trials by phase / activity

NCT	Phase	Status	Title
NCT06266494	PHASE4	RECRUITING	Prevention and Treatment of Frostbite Infection With Antimicrobial Pharmacokinetic Analysis
NCT07240649	PHASE4	NOT_YET_RECRUITING	Outcomes From Hyperbaric Oxygen (HBO2) Treatment for Emerging Indications
NCT07424378	PHASE4	NOT_YET_RECRUITING	Epoprostenol Plus Conventional Therapy in COld and Frostbite Injury (ECCO)
NCT05777590	Not specified	ACTIVE_NOT_RECRUITING	Comparison of ICG Microangiography and Conventional Angiography in Severe Frostbite
NCT07450469	Not specified	NOT_YET_RECRUITING	Field Study on Intravenous Iloprost for Treatment of Severe Frostbite at High Altitude
NCT03405467	Not specified	COMPLETED	10-years Nationwide Alpine Accidents in Austria
NCT04633174	Not specified	COMPLETED	Sous Vide Rewarming for Frostbitten Extremities
NCT05280301	Not specified	COMPLETED	Multicenter Sous Vide Frostbite

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
DALBAVANCIN	4	1
OXYGEN	4	1
ALOE	3	1
CHEMBL4778239	0	1
CHEMBL4785392	0	1
CHEMBL6174705	0	1