Functional colonic disease

Summary

Functional colonic disease (MONDO:0002802) is a disease and 5 clinical trials. Top therapeutic interventions include desipramine. A subtype of colonic disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 5

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	functional colonic disease
Mondo ID	MONDO:0002802
MeSH	D003109
DOID	DOID:3877
UMLS	C0009374
MedGen	40395
Is cancer (heuristic)	no

Disease family

This is a subtype of colonic disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › digestive system disorder › intestinal disorder › large intestine disorder › colonic disorder › functional colonic disease

Related subtypes (12): neuronal intestinal dysplasia, functional diarrhea, megacolon, diverticulitis of colon, cecal disorder, sigmoid disease, colitis, colonic neoplasm, colon dysplasia, polyp of colon, Chilaiditi syndrome, colonic duplication

Subtypes (1): colonic pseudo-obstruction

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 5.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	4
PHASE3	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT00006157	PHASE3	COMPLETED	Treatment of Functional Bowel Disorders
NCT06438068	Not specified	NOT_YET_RECRUITING	Influence of Modern Colon Hydrotherapy on Intestinal Transit
NCT00213317	Not specified	COMPLETED	Effect of Lumbo-sacral Magnetic Stimulation on Colonic Motility
NCT00518349	Not specified	COMPLETED	Colonoscope Passive Bending Function
NCT06653647	Not specified	COMPLETED	Efficacy of Guided Imagery Therapy Mobile Application for Functional Abdominal Pain

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
DESIPRAMINE	4	1