Functional diarrhea
diseaseOn this page
Summary
Functional diarrhea (MONDO:0001272) is a disease and 5 clinical trials. Top therapeutic interventions include loperamide and aldafermin. A subtype of colonic disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 5
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | functional diarrhea |
| Mondo ID | MONDO:0001272 |
| DOID | DOID:11371 |
| ICD-10-CM | K59.1 |
| SNOMED CT | 47812002 |
| UMLS | C0156173 |
| MedGen | 510199 |
| Is cancer (heuristic) | no |
Disease family
This is a subtype of colonic disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › digestive system disorder › intestinal disorder › large intestine disorder › colonic disorder › functional diarrhea
Related subtypes (12): neuronal intestinal dysplasia, megacolon, diverticulitis of colon, cecal disorder, sigmoid disease, functional colonic disease, colitis, colonic neoplasm, colon dysplasia, polyp of colon, Chilaiditi syndrome, colonic duplication
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 5.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 2 |
| PHASE2/PHASE3 | 1 |
| PHASE2 | 1 |
| PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT01350570 | PHASE2/PHASE3 | COMPLETED | Acupuncture for Patients With Diarrhea-predominant IBS or Functional Diarrhea: a Randomized Controlled Trial |
| NCT05130047 | PHASE2 | COMPLETED | Aldafermin (NGM282) for Chronic Diarrhea Due to Bile Acid Malabsorption (BAM) |
| NCT01274793 | PHASE1 | UNKNOWN | Trial for Quantity-Effect Relationship of Acupuncture With Two-ways Regulation to Treat Functional Enteropathy |
| NCT07148583 | Not specified | RECRUITING | BioAmicus Complete for Functional Gastrointestinal Symptoms in Infants Aged 0 to 24 Months |
| NCT03694223 | Not specified | COMPLETED | Health Education Delivery Methods for a Low Fermentable Carbohydrate Diet in Patients With Functional Bowel Disorders |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| LOPERAMIDE | 4 | 3 |
| ALDAFERMIN | 2 | 1 |
Related Atlas pages
- Drugs: Loperamide