Fungal keratitis
disease diseaseOn this page
Summary
Fungal keratitis (MONDO:0033821) is a disease and 11 clinical trials. Top therapeutic interventions include natamycin, rose bengal free acid, and voriconazole. A subtype of fungal infection of eye — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 11
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | fungal keratitis |
| Mondo ID | MONDO:0033821 |
| Orphanet | 519930 |
| ICD-11 | 712798367 |
| NCIT | C128370 |
| UMLS | C1262117 |
| MedGen | 687913 |
| GARD | 0022134 |
| Is cancer (heuristic) | no |
Disease family
This is a subtype of fungal infection of eye. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › fungal infectious disease › fungal infection of eye › fungal keratitis
Related subtypes (1): histoplasmosis retinitis
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 11.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| PHASE3 | 4 |
| Not specified | 4 |
| PHASE2 | 2 |
| PHASE1/PHASE2 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT06658002 | PHASE3 | RECRUITING | Fungal Ulcer Treatment Augmented With Natamycin and Cyclosporine A |
| NCT00516399 | PHASE3 | TERMINATED | A Clinical Trial of the Treatment of Fungal Corneal Ulcers With Povidone-Iodine |
| NCT02731638 | PHASE3 | COMPLETED | Mycotic Antimicrobial Localized Injection for Treatment of Corneal Ulcers |
| NCT05110001 | PHASE3 | COMPLETED | Rose Bengal Electromagnetic Activation With Green Light for Infection Reduction |
| NCT06463678 | PHASE2 | NOT_YET_RECRUITING | Trial to Evaluate the Efficacy And Safety of IVIEW-1201 In the Treatment of Fungal Keratitis |
| NCT00557362 | PHASE1/PHASE2 | COMPLETED | Therapeutic Exploratory Study of Comparing Natamycin and Voriconazole to Treat Fungal Corneal Ulcer |
| NCT01831206 | PHASE2 | COMPLETED | Collagen Cross-linking in Infectious Keratitis Trial |
| NCT02088970 | Not specified | TERMINATED | Safety and Efficacity of Corneal Collagen Crosslinking in Infectious Keratitis (Bacterial and Fungal ): Randomized,Controlled, Prospective Study. (CXL) |
| NCT05620264 | Not specified | UNKNOWN | Validation of Interleukins and Other Cytokines Together With OCT Imaging for Rapid Infectious Keratitis Assessment |
| NCT05655689 | Not specified | COMPLETED | The Antibiogram and Outcomes of Antimicrobial Regimens in Microbial Keratitis: A Prospective Cohort Study |
| NCT07557966 | Not specified | COMPLETED | Intrastromal Injection of Fluconazole in Treatment of Fungal Keratitis |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| NATAMYCIN | 4 | 4 |
| ROSE BENGAL FREE ACID | 4 | 2 |
| VORICONAZOLE | 4 | 2 |
| CEFTAZIDIME | 4 | 1 |
| CHLORHEXIDINE GLUCONATE | 4 | 1 |
| GENTAMICIN | 4 | 1 |
| MOXIFLOXACIN | 4 | 1 |
| POVIDONE-IODINE | 4 | 1 |
| CHEMBL4740747 | 0 | 4 |
| CHEMBL1628 | 0 | 1 |
| CHEMBL195892 | 0 | 1 |
| CHEMBL3039597 | 0 | 1 |
| CHEMBL4740200 | 0 | 1 |
| 17 | 0 | 1 |
| GENTAMICIN C1A | 0 | 1 |
| GENTAMICIN C2 | 0 | 1 |
| ROSE BENGAL | 0 | 1 |