Fungal meningitis

Summary

Fungal meningitis (MONDO:0006764) is a disease and 4 clinical trials. Top therapeutic interventions include d-lactic acid. A subtype of fungal infectious disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 4

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	fungal meningitis
Mondo ID	MONDO:0006764
EFO	EFO:1000942
MeSH	D016921
DOID	DOID:11608
ICD-11	1137081791
SNOMED CT	24321005
UMLS	C0085438
MedGen	39285
GARD	0024469
MedDRA	10017538
Is cancer (heuristic)	no

Also known as: Fungi caused infectious meningitis · Fungi infectious meningitis

Disease family

This is a subtype of fungal infectious disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › fungal infectious disease › fungal meningitis

Related subtypes (17): cutaneous mycosis, systemic mycosis, fungal esophagitis, opportunistic mycosis, fungal gastritis, fungal lung infectious disease, Pneumocystis infectious disease, sporotrichosis, fungal myositis, scedosporiosis, fungal infection of eye, mycotic endocarditis, mycotoxicosis, alternariosis, invasive scopulariopsis infection, emergomycosis, fungal discitis

Subtypes (2): histoplasmosis meningitis, Cryptococcal meningitis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 4.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	3
PHASE3	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT01802385	PHASE3	COMPLETED	Adjunctive Sertraline for the Treatment of HIV-Associated Cryptococcal Meningitis
NCT07027475	Not specified	RECRUITING	Acute Treatment and Long-term Assessment of Adult Infectious Meningitis
NCT07062445	Not specified	RECRUITING	Prospective Clinical Registry of Acute Treatment and Long-term Assessment of Children Meningitis
NCT05146570	Not specified	UNKNOWN	Early Diagnosis of Native and Device-associated Meningitis

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
D-LACTIC ACID	3	1
CHEMBL1788361	0	1