Fusariosis

Summary

Fusariosis (MONDO:0016426) is a disease and 4 clinical trials. A subtype of opportunistic mycosis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: Unknown (Worldwide)
• Phenotypes (HPO): 47
• Clinical trials: 4

Clinical features

Signs & symptoms

Clinical features (HPO)

47 HPO clinical features (Orphanet curated; top 47 by frequency):

HPO ID	Term	Frequency
HP:0020153	Positive blood 1,3 beta glucan test	Very frequent (80-99%)
HP:0000246	Sinusitis	Frequent (30-79%)
HP:0001875	Decreased total neutrophil count	Frequent (30-79%)
HP:0001945	Fever	Frequent (30-79%)
HP:0002090	Pneumonia	Frequent (30-79%)
HP:0002721	Immunodeficiency	Frequent (30-79%)
HP:0011356	Regional abnormality of skin	Frequent (30-79%)
HP:0012203	Onychomycosis	Frequent (30-79%)
HP:0020101	Invasive fungal infection	Frequent (30-79%)
HP:0001482	Subcutaneous nodule	Occasional (5-29%)
HP:0001818	Paronychia	Occasional (5-29%)
HP:0001888	Lymphopenia	Occasional (5-29%)
HP:0002105	Hemoptysis	Occasional (5-29%)
HP:0002113	Pulmonary infiltrates	Occasional (5-29%)
HP:0002202	Pleural effusion	Occasional (5-29%)
HP:0003326	Myalgia	Occasional (5-29%)
HP:0004377	Hematological neoplasm	Occasional (5-29%)
HP:0006516	Hypersensitivity pneumonitis	Occasional (5-29%)
HP:0025179	Ground-glass opacification on pulmonary HRCT	Occasional (5-29%)
HP:0031245	Productive cough	Occasional (5-29%)
HP:0031457	Pulmonary opacity	Occasional (5-29%)
HP:0032177	Parenchymal consolidation	Occasional (5-29%)
HP:0032252	Granuloma	Occasional (5-29%)
HP:0040186	Maculopapular exanthema	Occasional (5-29%)
HP:0100749	Chest pain	Occasional (5-29%)
HP:0200034	Papule	Occasional (5-29%)
HP:0200042	Skin ulcer	Occasional (5-29%)
HP:0000077	Abnormality of the kidney	Very rare (<1-4%)
HP:0000479	Abnormal retinal morphology	Very rare (<1-4%)
HP:0000491	Keratitis	Very rare (<1-4%)
HP:0001369	Arthritis	Very rare (<1-4%)
HP:0001392	Abnormality of the liver	Very rare (<1-4%)
HP:0001743	Abnormality of the spleen	Very rare (<1-4%)
HP:0002110	Bronchiectasis	Very rare (<1-4%)
HP:0002586	Peritonitis	Very rare (<1-4%)
HP:0002754	Osteomyelitis	Very rare (<1-4%)
HP:0008066	Abnormal blistering of the skin	Very rare (<1-4%)
HP:0011450	Unusual CNS infection	Very rare (<1-4%)
HP:0012490	Panniculitis	Very rare (<1-4%)
HP:0025044	Lung abscess	Very rare (<1-4%)
HP:0030049	Brain abscess	Very rare (<1-4%)
HP:0032156	Skin detachment	Very rare (<1-4%)
HP:0032172	Air crescent sign	Very rare (<1-4%)
HP:0100537	Fasciitis	Very rare (<1-4%)
HP:0100614	Myositis	Very rare (<1-4%)
HP:0100658	Cellulitis	Very rare (<1-4%)
HP:0410017	Otitis externa	Very rare (<1-4%)

Identifiers

Disease identifiers

Field	Value
Canonical name	fusariosis
Mondo ID	MONDO:0016426
EFO	EFO:1001795
MeSH	D060585
Orphanet	228119
DOID	DOID:0050289
ICD-11	565900954
SNOMED CT	64250002
UMLS	C0276758
MedGen	452375
GARD	0020570
MedDRA	10051919
Is cancer (heuristic)	no

Also known as: Fusarium caused disease or disorder · Fusarium disease or disorder · Fusarium infection · Fusarium infectious disease

Disease family

This is a subtype of opportunistic mycosis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › fungal infectious disease › opportunistic mycosis › fusariosis

Related subtypes (11): phaeohyphomycosis, candidiasis, maple bark strippers’ lung, aspergillosis, cryptococcosis, geotrichosis, microsporidiosis, pneumocystosis, Zygomycosis, opportunistic systemic mycosis, hyalohyphomycosis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

1 approved. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

Drug	Development status
Voriconazole	Approved (phase 4)

Clinical trials & evidence

Clinical trials

Clinical trials: 4.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	4

Top trials by phase / activity

NCT	Phase	Status	Title
NCT04937751	Not specified	RECRUITING	Markers of Infection and Resistance in Invasive Fusariosis
NCT00518778	Not specified	COMPLETED	Fusariosis in Solid-Organ Transplant Recipients
NCT02714504	Not specified	COMPLETED	Anti-mold Azole in the Prophylaxis for Invasive Fusariosis
NCT02984904	Not specified	COMPLETED	Fusarium Keratitits in Spain 2012 to 2014