Genital herpes
diseaseOn this page
Also known as herpes genitaliaherpes genitalis
Summary
Genital herpes (MONDO:0005770) is a disease and 48 clinical trials. Top therapeutic interventions include valacyclovir, acyclovir, and famciclovir. A subtype of herpes simplex infectious disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 48
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | genital herpes |
| Mondo ID | MONDO:0005770 |
| EFO | EFO:0007282 |
| MeSH | D006558 |
| DOID | DOID:8704 |
| NCIT | C14364 |
| SNOMED CT | 33839006 |
| UMLS | C0019342 |
| MedGen | 42436 |
| Anatomy (UBERON) | UBERON:0000990 |
| Is cancer (heuristic) | no |
Also known as: herpes genitalia · herpes genitalis
Disease family
This is a subtype of herpes simplex infectious disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › viral infectious disease › primary viral infectious disease › Herpesviridae infectious disease › herpes simplex infectious disease › genital herpes
Related subtypes (9): herpetic whitlow, herpes simplex dermatitis, herpes simplex virus gingivostomatitis, herpes simplex encephalitis, herpes simplex virus keratitis, congenital herpes simplex virus infection, herpes labialis, herpes simplex type 1 infectious disease, herpes simplex type 2 infectious disease
Subtypes (2): genital herpes simplex type 2 infectious disorder, genital herpes simplex type 1 infectious disorder
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
Drugs indicated for this disease
3 approved. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.
| Drug | Development status |
|---|---|
| Acyclovir | Approved (phase 4) |
| Famciclovir | Approved (phase 4) |
| Valacyclovir | Approved (phase 4) |
Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Amenamevir, Pritelivir, Sodium Chloride.
Clinical trials & evidence
Clinical trials
Clinical trials: 48.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 13 |
| PHASE2 | 12 |
| PHASE4 | 10 |
| PHASE3 | 8 |
| PHASE1 | 4 |
| PHASE1/PHASE2 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00079911 | PHASE4 | TERMINATED | A Clinical Research Study For The Suppression And Treatment Of Genital Herpes Infection In HIV-Infected Persons |
| NCT00129818 | PHASE4 | COMPLETED | A Study to Evaluate the Effect of Famciclovir in Reducing Herpes Virus Shedding |
| NCT00158860 | PHASE4 | COMPLETED | A Study Comparing Daily Treatment With Valaciclovir To Placebo For Suppression Of Herpes Simplex Virus HSV-2 Genital Herpes In Newly Diagnosed Patients. VALTREX® Tablet is a Trademark of the GlaxoSmithKline Group of Companies. |
| NCT00362297 | PHASE4 | COMPLETED | Randomized Trial to Evaluate Suppressive Effect of High-Dose Acyclovir Versus Once-Daily Valacyclovir on Persons With HSV-2 |
| NCT00477334 | PHASE4 | COMPLETED | Patient-initiated Episodic Treatment of Recurrent Genital Herpes in Black Patients |
| NCT00495716 | PHASE4 | TERMINATED | Effect of HSV-2 Suppressive Therapy on Sexual Behavior |
| NCT00527618 | PHASE4 | COMPLETED | Trial to Study the Effect of Dose of Herpes Simplex Virus-2 (HSV-2) Suppressive Therapy on HSV and HIV |
| NCT00723229 | PHASE4 | COMPLETED | A Randomized Trial to Evaluated the Suppressive Effect of Acyclovir on Rapidly Cleared HSV-2 Reactivation |
| NCT01346475 | PHASE4 | COMPLETED | Randomized Trial to Evaluate Suppressive Effect of High-Dose Valacyclovir Versus Once-Daily Valacyclovir on Persons With HSV-2 |
| NCT03831165 | PHASE4 | COMPLETED | Melatonin Effects on Genital Herpes in Brazilian Women |
| NCT00005663 | PHASE3 | UNKNOWN | A Study of Valacyclovir as Treatment for Genital Herpes Simplex Virus in HIV-Infected Patients |
| NCT00076232 | PHASE3 | COMPLETED | A Study of Acyclovir to Help Prevent HIV Infection in People With Genital Herpes |
| NCT00122525 | PHASE3 | TERMINATED | Effect of Male Circumcision on HIV Incidence (ANRS 1265) |
| NCT00124878 | PHASE3 | UNKNOWN | Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community |
| NCT00171990 | PHASE3 | COMPLETED | Efficacy and Safety of Oral Famciclovir in Patients With Active Recurrent Genital Herpes |
| NCT00262106 | PHASE3 | COMPLETED | Trial to Evaluate PRO 2000/5 Gels for the Prevention of Vaginally Acquired HIV Infection |
| NCT00306787 | PHASE3 | COMPLETED | Efficacy and Safety of Famciclovir 1-day Treatment Compared to 3-day Treatment With Valacyclovir in Adults With Recurrent Genital Herpes |
| NCT01281007 | PHASE3 | COMPLETED | Efficacy of Oral Famciclovir 125mg Comparing to Aciclovir 200 mg Treatment in Patients With Active Recurrent Genital Herpes |
| NCT04979975 | PHASE2 | NOT_YET_RECRUITING | Evaluating Safety and Efficacy of Repeat Doses of UB-621in Adult Patients With Recurrent Genital Herpes |
| NCT00158483 | PHASE2 | COMPLETED | Anti-Herpetic Treatment of Genital Ulcer : Effect on HIV & Herpes Shedding (ANRS 1212) |
| NCT00158509 | PHASE2 | COMPLETED | Randomised Controlled Trial Assessing the Impact of Genital Herpes Suppressive Therapy on HIV Shedding |
| NCT00405821 | PHASE2 | COMPLETED | Acyclovir to Treat Patients Co-infected With HIV and Herpes Viruses in Uganda |
| NCT00486200 | PHASE2 | COMPLETED | A Study With ASP2151 in Subjects With Recurrent Episodes of Genital Herpes |
| NCT01658826 | PHASE2 | TERMINATED | Safety and Efficacy Comparator Trial of a New Drug Against Genital Herpes |
| NCT01765114 | PHASE2 | TERMINATED | A Study to Investigate the Efficacy, Safety and Tolerability of PEG in Patients With Genital Herpes |
| NCT02837575 | PHASE2 | COMPLETED | Safety and Efficacy Study of Herpes Simplex Virus Type 2 (HSV-2) Therapeutic DNA Vaccine |
| NCT03146403 | PHASE2 | TERMINATED | Maintenance Dose Study of GEN-003 in Subjects With Genital Herpes Infection |
| NCT03595995 | PHASE2 | UNKNOWN | A Phase 2 Trial to Evaluate the Safety and Efficacy of UB-621 |
| NCT04165122 | PHASE2 | COMPLETED | Monoclonal Antibody Therapy Against Chronic Herpes Simplex Virus 2 Infection |
| NCT04714060 | PHASE2 | UNKNOWN | UB-621, a New Type of Anti-herpes Simplex Virus (HSV) Monoclonal Antibody for the Use in the Treatment of Adult Recurrent HSV-2 Infections of the Genitals |
| NCT06033261 | PHASE1/PHASE2 | COMPLETED | A Study of mRNA-1608, a Herpes Simplex Virus -2 (HSV-2) Therapeutic Candidate Vaccine, in Healthy Adults 18 to 55 Years of Age With Recurrent HSV-2 Genital Herpes |
| NCT07330440 | PHASE1 | ENROLLING_BY_INVITATION | A Phase I Study to Evaluate the Safety, Tolerability, and Immunogenicity of an mRNA Vaccine Against Herpes Simplex Virus Type 2 (HSV-2) Post-Vaccination |
| NCT00231049 | PHASE1 | COMPLETED | Trial Evaluating Safety, Tolerability and Immune Response of AG-707 |
| NCT02852876 | PHASE1 | COMPLETED | Study to Evaluate the Safety and Pharmacokinetics of Single Doses of ASP2151 in Healthy Male Subjects and the Effects of Food |
| NCT04222985 | PHASE1 | TERMINATED | Safety and Efficacy of 4 Investigational HSV 2 Vaccines in Adults With Recurrent Genital Herpes Caused by HSV 2 |
| NCT00023582 | Not specified | COMPLETED | HIV and Genital Herpes Among High-Risk Men Who Have Sex With Men (MSM) in Lima, Peru |
| NCT00495573 | Not specified | COMPLETED | HSV-2 Shedding Resolution After Acyclovir Treatment |
| NCT00808405 | Not specified | COMPLETED | GUD Clinical and Virologic Response to Acyclovir in HIV Negative African Women |
| NCT01112956 | Not specified | COMPLETED | Serologic Assays for the Diagnosis of Herpes Simplex Virus Type 2 |
| NCT01132716 | Not specified | COMPLETED | Bioequivalency Study of Valacyclovir Hydrochloride 1000 mg Under Fed Conditions |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| VALACYCLOVIR | 4 | 34 |
| ACYCLOVIR | 4 | 11 |
| FAMCICLOVIR | 4 | 5 |
| AMENAMEVIR | 4 | 2 |
| MELATONIN | 4 | 1 |
| PRITELIVIR | 3 | 1 |
Related Atlas pages
- Drugs: Valacyclovir, Acyclovir, Famciclovir, Amenamevir, Melatonin, Pritelivir