Gestational choriocarcinoma

Summary

Gestational choriocarcinoma (MONDO:0020550) is a disease. A subtype of female reproductive organ cancer — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Prevalence: Unknown (Worldwide) [Orphanet-validated]
• Phenotypes (HPO): 6

Clinical features

Signs & symptoms

Clinical features (HPO)

6 HPO clinical features (Orphanet curated; top 6 by frequency):

HPO ID	Term	Frequency
HP:0100768	Choriocarcinoma	Obligate (100%)
HP:0002664	Neoplasm	Very frequent (80-99%)
HP:0005268	Spontaneous abortion	Very frequent (80-99%)
HP:0011433	High maternal serum chorionic gonadotropin	Very frequent (80-99%)
HP:0031502	Trophoblastic tumor	Very frequent (80-99%)
HP:0100608	Metrorrhagia	Very frequent (80-99%)

Identifiers

Disease identifiers

Field	Value
Canonical name	gestational choriocarcinoma
Mondo ID	MONDO:0020550
Orphanet	99926
DOID	DOID:2025
ICD-11	2136066651
NCIT	C4646
SNOMED CT	417570003
UMLS	C0349557
MedGen	138102
GARD	0019712
Is cancer (heuristic)	no

Also known as: gestational choriocarcinoma · gestational choriocarcinoma (morphologic abnormality)

Data availability: 53 cell lines.

Disease family

This is a subtype of female reproductive organ cancer. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › cancer › reproductive system cancer › female reproductive organ cancer › gestational choriocarcinoma

Related subtypes (8): vaginal cancer, vulva cancer, fallopian tube cancer, uterine cancer, adenocarcinofibroma, endometrioid adenocarcinoma, adenosarcoma, ovarian cancer

Subtypes (4): gestational ovarian choriocarcinoma, fallopian tube gestational choriocarcinoma, uterine corpus choriocarcinoma, placental choriocarcinoma

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.