Gestational trophoblastic neoplasm
diseaseOn this page
Also known as gestational trophoblastic diseasegestational trophoblastic tumorgestational trophoblastic tumourGTNGTT
Summary
Gestational trophoblastic neoplasm (MONDO:0018944) is a cancer (an umbrella term covering 6 Mondo subtypes) and 38 clinical trials. Top therapeutic interventions include dactinomycin, granisetron, and methotrexate. A subtype of trophoblastic neoplasm — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Classification: Cancer
- Prevalence: Unknown (Worldwide) [Orphanet-validated]
- Umbrella term: 6 Mondo subtypes
- Clinical trials: 38
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | gestational trophoblastic neoplasm |
| Mondo ID | MONDO:0018944 |
| Orphanet | 59305 |
| DOID | DOID:3590 |
| ICD-11 | 1972855304 |
| NCIT | C4699 |
| SNOMED CT | 609519004 |
| UMLS | C1135868 |
| MedGen | 210107 |
| GARD | 0006498 |
| MedDRA | 10061988 |
| Is cancer (heuristic) | yes |
Also known as: gestational trophoblastic disease · gestational trophoblastic tumor · gestational trophoblastic tumour · GTN · GTT
Disease family
This is a subtype of trophoblastic neoplasm. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by etiologic mechanism › cancer or benign tumor › neoplastic disease or syndrome › neoplasm › trophoblastic neoplasm › gestational trophoblastic neoplasm
Related subtypes (3): testicular trophoblastic tumor, choriocarcinoma, hydatidiform mole
Subtypes (6): hydatidiform mole, recurrent, 1, hydatidiform mole, recurrent, 2, epithelioid trophoblastic tumor, invasive hydatidiform mole, gestational choriocarcinoma, placental site trophoblastic tumor
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 38.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 15 |
| PHASE2 | 12 |
| PHASE3 | 4 |
| PHASE2/PHASE3 | 4 |
| PHASE1/PHASE2 | 2 |
| PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT00058071 | PHASE3 | COMPLETED | Amifostine in Treating Peripheral Neuropathy in Patients Who Have Received Chemotherapy for Cancer |
| NCT00324324 | PHASE3 | TERMINATED | Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem Cell Transplant |
| NCT01823315 | PHASE3 | UNKNOWN | Methotrexate Single-dose Treatment and Methotrexate/Actinomycin-D Single-dose Treatment in Low-Risk Gestational Trophoblastic Neoplasia |
| NCT02606539 | PHASE2/PHASE3 | UNKNOWN | Surgery Plus Single Agent Chemotherapy Versus Primary Chemotherapy for Gestational Trophoblastic Neoplasms |
| NCT02639650 | PHASE3 | UNKNOWN | Study of Paclitaxel Plus Cisplatin as the First-line Chemotherapy in High Risk Gestational Trophoblastic Tumor |
| NCT03280979 | PHASE2/PHASE3 | UNKNOWN | Rescue Regimen and High Dose Methotrexate in Management of Presistent Gestational Trophoplastic Neoplasia |
| NCT03885388 | PHASE2/PHASE3 | UNKNOWN | Combination of Methotrexate(MTX) and Actinomycin(ACTD) in the Low Risk Gestational Trophoblastic Neoplasma （GTN） Patients With Score of 5-6 |
| NCT05203562 | PHASE2/PHASE3 | UNKNOWN | Letrozole as a Prophylaxis From GTN for Complete Mole Patients |
| NCT02834013 | PHASE2 | ACTIVE_NOT_RECRUITING | Nivolumab and Ipilimumab in Treating Patients With Rare Tumors |
| NCT05635344 | PHASE2 | RECRUITING | A Feasibility Window Study of Pembrolizumab Prior to Second Evacuation for Post-molar Gestational Trophoblastic Neoplasia |
| NCT06790706 | PHASE2 | RECRUITING | IMMUNORARE5: A National Platform of 5 Academic Phase II Trials Coordinated by Lyon University Hospital to Assess the Safety and the Efficacy of the IMMUNOtherapy With Domvanalimab + Zimberelimab Combination in Patients With Advanced RARE Cancers |
| NCT00003408 | PHASE2 | COMPLETED | Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer |
| NCT00003688 | PHASE2 | COMPLETED | Dactinomycin in Treating Patients With Persistent or Recurrent Gestational Trophoblastic Neoplasia |
| NCT00003887 | PHASE2 | COMPLETED | Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation |
| NCT00004157 | PHASE2 | COMPLETED | Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin’s Lymphoma, Hodgkin’s Disease, Breast Cancer, or Other Solid Tumors |
| NCT00010283 | PHASE1/PHASE2 | COMPLETED | Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon |
| NCT00064311 | PHASE1/PHASE2 | COMPLETED | Ravuconazole in Preventing Fungal Infections in Patients Undergoing Allogeneic Stem Cell Transplantation |
| NCT00096187 | PHASE2 | TERMINATED | Pemetrexed Disodium in Treating Patients With Recurrent or Persistent Low-Risk Gestational Trophoblastic Tumor After a Molar Pregnancy |
| NCT00109993 | PHASE2 | COMPLETED | Campath-1H + FK506 and Methylprednisolone for GVHD |
| NCT00410657 | PHASE2 | COMPLETED | Alemtuzumab and Glucocorticoids in Treating Newly Diagnosed Acute Graft-Versus-Host Disease in Patients Who Have Undergone a Donor Stem Cell Transplant |
| NCT01764802 | PHASE2 | COMPLETED | Psychosexual Intervention in Patients With Stage I-III Gynecologic or Breast Cancer |
| NCT04047017 | PHASE2 | COMPLETED | Camrelizumab Combined With Apatinib for Recurrent Resistant GTN |
| NCT00003107 | PHASE1 | COMPLETED | Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors |
| NCT02892877 | Not specified | RECRUITING | The French National Reference Centre of GTD |
| NCT04562558 | Not specified | ACTIVE_NOT_RECRUITING | Biweekly Actinomycin-D Treatment or Multi-day Methotrexate Protocol in Low-risk Gestational Trophoblastic Neoplasia |
| NCT06339827 | Not specified | RECRUITING | ASk Questions in GYnecologic Oncology (ASQ-GYO) |
| NCT00082654 | Not specified | COMPLETED | Study of the Emotional Needs of Caregivers of Stem Cell Transplantation Patients |
| NCT00256802 | Not specified | COMPLETED | The Diameter of the Middle Cerebral Artery Measured With Magnetic Resonance Angiography |
| NCT00293384 | Not specified | COMPLETED | Aprepitant, Granisetron, & Dexamethasone in Preventing Nausea & Vomiting in Pts. Receiving Cyclophosphamide Before a Stem Cell Transplant |
| NCT00651716 | Not specified | TERMINATED | T Cells in Predicting Acute Graft-Versus-Host Disease in Patients Undergoing Donor Stem Cell Transplant |
| NCT00706875 | Not specified | COMPLETED | A Global Assessment of Medical, Emotional and Reproductive Concerns in Gestational Trophoblastic Disease Survivors |
| NCT00897442 | Not specified | COMPLETED | Collecting Tumor Samples From Patients With Gynecological Tumors |
| NCT00900068 | Not specified | TERMINATED | Blood Samples From Patients on a Clinical Trial to CINV During HSCT |
| NCT00900406 | Not specified | COMPLETED | Collecting and Storing Tissue and DNA Samples From Patients Undergoing a Donor Stem Cell Transplant |
| NCT01764789 | Not specified | COMPLETED | Stress Reduction in Improving Quality of Life in Patients With Recurrent Gynecologic or Breast Cancer |
| NCT02096783 | Not specified | COMPLETED | Scripted Sexual Health Informational Intervention in Improving Sexual Function in Patients With Gynecologic Cancer |
| NCT04028479 | Not specified | COMPLETED | The Registry of Oncology Outcomes Associated With Testing and Treatment |
| NCT06242522 | Not specified | UNKNOWN | Fertility and Pregnancy After Avelumab Treatment |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| DACTINOMYCIN | 4 | 3 |
| GRANISETRON | 4 | 3 |
| METHOTREXATE | 4 | 3 |
| ALEMTUZUMAB | 4 | 2 |
| ALDESLEUKIN | 4 | 1 |
| AMIFOSTINE | 4 | 1 |
| BECLOMETHASONE DIPROPIONATE | 4 | 1 |
| MOXIFLOXACIN HYDROCHLORIDE | 4 | 1 |
| SARGRAMOSTIM | 4 | 1 |
| CAMRELIZUMAB | 3 | 1 |
| DOMVANALIMAB | 3 | 1 |
| ZIMBERELIMAB | 3 | 1 |
| EDODEKIN ALFA | 2 | 1 |
| RAVUCONAZOLE | 2 | 1 |
| CHEMBL4748391 | 0 | 3 |
| CHEMBL427947 | 0 | 1 |
| CHEMBL4299292 | 0 | 1 |
| CHEMBL1319520 | 0 | 1 |
| CHEMBL1900758 | 0 | 1 |