Gingival cancer

Summary

Gingival cancer (MONDO:0005507) is a cancer with 1 GWAS associations across 1 studies and 1 clinical trial. A subtype of musculoskeletal system cancer — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• GWAS associations: 1
• Clinical trials: 1

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	gingival cancer
Mondo ID	MONDO:0005507
EFO	EFO:0005557
DOID	DOID:8602
ICD-10-CM	C03
ICD-11	1719710858
NCIT	C9317
SNOMED CT	363382005
UMLS	C0153364
MedGen	57549
GARD	0024198
MedDRA	10067807
Anatomy (UBERON)	UBERON:0001828
Is cancer (heuristic)	yes

Also known as: cancer of gingiva · gingiva cancer · malignant gingiva neoplasm · malignant gingival neoplasm · malignant gingival tumor · malignant gingival tumour · malignant gum neoplasm · malignant gum tumor · malignant gum tumour · malignant neoplasm of gingiva · malignant neoplasm of gum · malignant neoplasm of the gingiva · malignant neoplasm of the gum · malignant tumor of gingiva · malignant tumor of gum · malignant tumor of the gingiva · malignant tumor of the gum · malignant tumour of gingiva · malignant tumour of gum · malignant tumour of the gingiva (+1 more)

Data availability: 1 GWAS association (1 study).

Disease family

This is a subtype of musculoskeletal system cancer. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › musculoskeletal system cancer › gingival cancer

Related subtypes (10): cartilage cancer, broad ligament malignant neoplasm, round ligament malignant neoplasm, laryngeal cartilage cancer, bone cancer, synovium cancer, uterine ligament cancer, tonsillar pillar cancer, muscle cancer, ameloblastic carcinoma

Subtypes (2): upper gum cancer, lower gum cancer

Genetics & variants

GWAS landscape

1 GWAS associations across 1 studies. Top hits map to 1 distinct genes (as reported by GWAS).

Top associations by p-value

rsID	p-value	Gene	Risk allele	Odds ratio
rs1058026	5e-09	HLA-B	?

Top studies (by case count)

Study	Lead author	Year	Cases	Controls	Title
GCST90651377	Liu TY	2025	319	231,112	Diversity and longitudinal records: Genetic architecture of disease associations and polygenic risk in the Taiwanese Han population.

Variant details and genetic-evidence tiers

Tier distribution (top 50 variants)

Tier	Variants
Tier 1: coding	0
Tier 2: splice/UTR	1
Tier 3: regulatory	0
Tier 4: intronic/intergenic	0

MAF distribution

Bucket	Variants
common (>=0.05)	1
low_freq (0.01-0.05)	0
rare (<0.01)	0
unknown	0

Functional consequences

Consequence	Count
3_prime_UTR_variant	1

Top variants

rsID	Chr	Pos	Alleles	MAF	Consequence	Gene	p-value	Tier
rs1058026	6	31353908	A>C	0.05	3_prime_UTR_variant	HLA-B	5e-09	Tier 2: splice/UTR

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 1.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT03137953	Not specified	UNKNOWN	Role of Imaging to Predict the Deep Surgical Margin in Gingivobuccal Complex Tumors