Gingival recession

Summary

Gingival recession (MONDO:0001268) is a disease and 315 clinical trials. Top therapeutic interventions include metamizole, chlorhexidine, and hyaluronic acid. A subtype of gingival disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 315

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	gingival recession
Mondo ID	MONDO:0001268
MeSH	D005889
DOID	DOID:1134
ICD-10-CM	K06.0
ICD-11	1059404242
SNOMED CT	59898000
UMLS	C0017572
MedGen	6607
Is cancer (heuristic)	no

Also known as: gingival recession · gingival recession, localised · gingival recession, localized · gingival recession, unspecified · localised gingival recession

Disease family

This is a subtype of gingival disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › musculoskeletal system disorder › skeletal system disorder › periodontal disorder › gingival disorder › gingival recession

Related subtypes (5): gingival overgrowth, gingivitis, pericoronitis, gingival neoplasm, leukoplakia of gingiva

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 315.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	273
PHASE4	22
PHASE2	5
PHASE3	4
PHASE1/PHASE2	4
EARLY_PHASE1	4
PHASE2/PHASE3	3

Top trials by phase / activity

NCT	Phase	Status	Title
NCT03057730	PHASE4	ACTIVE_NOT_RECRUITING	A Clinical Trial Testing Root Coverage With Acellular Dermal Matrix in Thin and Thick Gingival Biotypes
NCT06634043	PHASE4	NOT_YET_RECRUITING	Coronally Advanced Tunnel Combined With Xenogenic Dermal Matrix and L-PRF
NCT00720707	PHASE4	COMPLETED	Coronally Advanced Flap in Combination With Acellular Dermal Matrix and Enamel Matrix Derivatives for Root Coverage
NCT01440426	PHASE4	COMPLETED	Connective Tissue Graft Versus Mucograft Collagen Matrix for Coverage of Multiple Gingival Recession Defects
NCT02230787	PHASE4	COMPLETED	Gingival Recession Coverage With and Without Emdogain
NCT02242500	PHASE4	COMPLETED	Coronally Advanced Flap With or Without Porcine Collagen Matrix for Root Coverage
NCT02433899	PHASE4	COMPLETED	Microsurgical Versus Conventional Semilunar Coronally Advanced Flap
NCT02433912	PHASE4	COMPLETED	Clinical Evaluation of Single-stage Advanced Versus Rotated Flaps in the Treatment of Gingival Recessions
NCT02438046	PHASE4	UNKNOWN	Platelet Rich Fibrin in the Treatment of Palatal Wounds
NCT02456337	PHASE4	COMPLETED	Xenogenous Collagen Matrix Graft With or Without Enamel Matrix Proteins Derivative for Root Coverage
NCT02459704	PHASE4	COMPLETED	Semilunar Coronally Positioned Flap With or Without Enamel Matrix Derivative for the Treatment of Gingival Recessions
NCT02486991	PHASE4	COMPLETED	Tunnel With and Without Intramucosal Vertical Incisions
NCT02626117	PHASE4	UNKNOWN	Laser De-epithelialization for Epithelial Exclusion in Root Coverage Procedure: a Clinical Study
NCT02632968	PHASE4	UNKNOWN	Pinhole Surgical Technique With And Without Use Of Buttons For Treatment Of Multiple Gingival Recessions: RCT
NCT02818855	PHASE4	COMPLETED	Treatment of Multiple Gingival Recessions
NCT02835430	PHASE4	COMPLETED	Coronally Advanced Flap and PRF With or Without Demineralized Freeze-dried Bone Allograft in Gingival Recession
NCT03059966	PHASE4	COMPLETED	Evaluation of the Inflammatory and Healing Profile After Root Coverage With Emdogain®
NCT04614350	PHASE4	COMPLETED	Pilot Study for Healing and Safety Outcomes in Gingival Recession
NCT04692558	PHASE4	UNKNOWN	Effect of Hyaluronic Acid on Gingival Recession Treatment
NCT05782751	PHASE4	COMPLETED	Growth Factor Enhanced Matrix With Subepithelial Connective Tissue Graft or Collagen Membrane in Treatment of Gingival Recession
NCT06388447	PHASE4	UNKNOWN	Reconstruction of Deficient Interdental Papilla Using Stem Cells vs Physiological Saline
NCT06508476	PHASE4	COMPLETED	The Efficacy of Amnion Chorion Allograft in Management of Gingival Recession.
NCT06643507	PHASE2/PHASE3	RECRUITING	Evaluation of the Modified VISTA Technique Using ALB-PRF vs CTG in the Treatment of Multiple Miller Class III Recessions
NCT07590375	PHASE2/PHASE3	NOT_YET_RECRUITING	Topical Phenytoin for Management of Gingival Recession
NCT00587834	PHASE3	COMPLETED	Safety and Efficacy of Gintuit(TM)for Oral Soft Tissue Regeneration
NCT02896283	PHASE2/PHASE3	COMPLETED	Effect of Low-Level Laser on Pain and Healing of Donor Site Following Free Gingival Graft
NCT03023995	PHASE3	COMPLETED	Coronally Advanced Flap With Connective Tissue Graft and PRF for Recession Coverage
NCT05990049	PHASE3	UNKNOWN	Hyaluronic Acid and Free Gingival Graft Healing
NCT07345520	PHASE3	COMPLETED	VCMX, PRF and SCTG Treatment in the Gingival Recessions
NCT06871475	PHASE2	NOT_YET_RECRUITING	The Effect Of Using Sticky Bone With Coronally Advanced Flap In Management Of Type 1 Gingival Recession
NCT00679081	PHASE1/PHASE2	TERMINATED	A Pilot Study of CelTx(TM) (Apligraf®) in the Treatment of Gingival Recession Requiring Root Coverage
NCT01814592	PHASE2	UNKNOWN	Comparison Between Two Coronally Positioned Flap With Connective Tissue
NCT02135471	PHASE2	COMPLETED	Root Coverage in Smokers With Acellular Dermal Matrix Graft and Enamel Matrix Derivative
NCT02980055	PHASE2	UNKNOWN	Comparison of Root Coverage of Gingival Recessions
NCT03728244	PHASE1/PHASE2	UNKNOWN	MEBO Ointment and Hyaluronic Acid Gel in the Management of Pain After Free Gingival Graft Harvesting
NCT03871218	PHASE2	COMPLETED	Effect of Hyaluronic-acid on the Healing After Free Gingival Graft
NCT04434794	PHASE1/PHASE2	COMPLETED	Treatment of Gingival Recession Using Mesenchymal Stem Cells
NCT07437885	PHASE1/PHASE2	COMPLETED	Effects of the Adjunctive Use of Hyaluronic Acid-based Gel With Coranally Advanced Flap in the Gingival Recession
NCT02335866	EARLY_PHASE1	COMPLETED	Platelet-Rich Fibrin in the Treatment of Multiple Gingival Recessions
NCT02659904	EARLY_PHASE1	COMPLETED	The Quantitative Changes in Palatal Donor Sites Thickness After Free Gingival Graft Harvesting

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
METAMIZOLE	4	20
CHLORHEXIDINE	4	4
HYALURONIC ACID	4	2
PHENYTOIN	4	2
MECRYLATE	3	4
EDETIC ACID	3	1
FIBRIN	3	1
EFROFILCON A	1	1
CHEMBL5592090	0	1
CHEMBL402812	0	1
E968	0	1