Glossitis

Summary

Glossitis (MONDO:0006771) is a disease with 1 GWAS associations across 4 studies. A subtype of tongue disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• GWAS associations: 1

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	glossitis
Mondo ID	MONDO:0006771
EFO	EFO:1000951
MeSH	D005928
DOID	DOID:1456
ICD-10-CM	K14.0
ICD-11	843084384
SNOMED CT	45534005
UMLS	C0017675
MedGen	6618
MedDRA	10018386
Is cancer (heuristic)	no

Also known as: inflammation of tongue · tongue inflammation

Data availability: 1 GWAS association (4 studies).

Disease family

This is a subtype of tongue disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › mouth disorder › tongue disorder › glossitis

Related subtypes (8): hypertrophy of tongue papillae, hairy tongue, ankyloglossia, fissured tongue, isolated congenital hypoglossia/aglossia, digestive duplication cyst of the tongue, tongue neoplasm, glossodynia

Subtypes (2): median rhomboid glossitis, atrophic glossitis

Genetics & variants

GWAS landscape

1 GWAS associations across 4 studies. Top hits map to 1 distinct genes (as reported by GWAS).

Top associations by p-value

rsID	p-value	Gene	Risk allele	Odds ratio
rs7096715	1e-07	PRXL2A	?

Top studies (by case count)

Study	Lead author	Year	Cases	Controls	Title
GCST90482129	Verma A	2024	382	449,648	Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.
GCST90651852	Liu TY	2025	355	215,085	Diversity and longitudinal records: Genetic architecture of disease associations and polygenic risk in the Taiwanese Han population.
GCST90436299	Zhou W	2018	300	403,323	Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies.
GCST90044118	Jiang L	2021	247	456,101	A generalized linear mixed model association tool for biobank-scale data.

Variant details and genetic-evidence tiers

Tier distribution (top 50 variants)

Tier	Variants
Tier 1: coding	0
Tier 2: splice/UTR	1
Tier 3: regulatory	0
Tier 4: intronic/intergenic	0

MAF distribution

Bucket	Variants
common (>=0.05)	1
low_freq (0.01-0.05)	0
rare (<0.01)	0
unknown	0

Functional consequences

Consequence	Count
3_prime_UTR_variant	1

Top variants

rsID	Chr	Pos	Alleles	MAF	Consequence	Gene	p-value	Tier
rs7096715	10	80436193	T>A,C,G	0.05	3_prime_UTR_variant	PRXL2A	1e-07	Tier 2: splice/UTR

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.