Gonorrhea

Summary

Gonorrhea (MONDO:0004277) is a disease (an umbrella term covering 12 Mondo subtypes) and 94 clinical trials. Top therapeutic interventions include ceftriaxone, doxycycline anhydrous, and azithromycin. A subtype of primary bacterial infectious disease — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Umbrella term: 12 Mondo subtypes
• Clinical trials: 94

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	gonorrhea
Mondo ID	MONDO:0004277
MeSH	D006069
Orphanet	100642
DOID	DOID:7551
NCIT	C92950
SNOMED CT	15628003
UMLS	C0018081
MedGen	9077
Is cancer (heuristic)	no

Also known as: acrodermatitis, infantile lichenoid · acrodermatitis, papular infantile · Crosti-gianotti syndrome · GC · Gianotti Crosti syndrome · infections, Neisseria gonorrhoeae · Neisseria gonorrhoeae infection · PAC · papular acrodermatitis of childhood · PAS

Disease family

This is a subtype of primary bacterial infectious disease. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › bacterial infectious disease › primary bacterial infectious disease › gonorrhea

Related subtypes (36): Buruli ulcer disease, sennetsu fever, salmonellosis, pinta disease, chancroid, anthrax infection, leprosy, botulism, diphtheria, tetanus, bartonellosis, brucellosis, campylobacteriosis, glanders, granuloma inguinale, legionellosis, leptospirosis, listeriosis, Mycobacterium avium complex disease, ornithosis, rhinoscleroma, staphyloenterotoxemia, syphilis, cholera, ehrlichiosis, melioidosis, tuberculosis, tularemia, plague, Q fever, shigellosis, Lyme disease, relapsing fever, spirillary rat-bite fever, streptobacillary rat-bite fever, Borrelia miyamotoi disease

Subtypes (12): gonococcal seminal vesiculitis, gonococcal spondylitis, gonococcal bursitis, gonococcal endophthalmia, gonococcal conjunctivitis, gonococcal urethritis, gonococcal cervicitis, gonococcal epididymo-orchitis, gonococcal salpingitis, gonococcal cystitis, gonococcal prostatitis, gonococcal infection of joint

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

Drugs indicated for this disease

4 approved, 8 in late-stage (phase 3) trials. Disease-direct ChEMBL indications, not inferred from the associated-gene cohort below.

Drug	Development status
Amoxicillin	Approved (phase 4)
Ampicillin	Approved (phase 4)
Cefixime	Approved (phase 4)
Ciprofloxacin	Approved (phase 4)
Azithromycin	Phase 3 (in late-stage trials)
Ceftriaxone	Phase 3 (in late-stage trials)
Delafloxacin	Phase 3 (in late-stage trials)
Ertapenem	Phase 3 (in late-stage trials)
Fosfomycin	Phase 3 (in late-stage trials)
Gepotidacin	Phase 3 (in late-stage trials)
Solithromycin	Phase 3 (in late-stage trials)
Zoliflodacin	Phase 3 (in late-stage trials)

Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Aztreonam, Influenza Virus Vaccine.

Clinical trials & evidence

Clinical trials

Clinical trials: 94.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	63
PHASE3	12
PHASE4	9
PHASE2	6
PHASE1	2
PHASE2/PHASE3	1
PHASE1/PHASE2	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT06188442	PHASE4	RECRUITING	Superiority of On-demand PrEP Versus PEP on Using Doxycycline for Preventing STI in MSM
NCT06738407	PHASE4	RECRUITING	Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections
NCT07397403	PHASE4	RECRUITING	The Efficacy of Doxycycline Post Exposure Prophylaxis for Preventing STIs Among MSM in Bangkok, Thailand.
NCT01329588	PHASE4	COMPLETED	Periodical Presumptive Treatment for the Control of Gonococcal Infections Among Sex Workers
NCT01665690	PHASE4	COMPLETED	Washington State Community Expedited Partner Treatment (EPT) Trial
NCT03980223	PHASE4	COMPLETED	Evaluation of Doxycycline Post-exposure Prophylaxis to Reduce Sexually Transmitted Infections in PrEP Users and HIV-infected Men Who Have Sex With Men
NCT04094883	PHASE4	COMPLETED	Study to Assess Gonorrhoeae Immune Responses Induced by a N. Meningitidis Vaccine
NCT04202068	PHASE4	COMPLETED	A Study Evaluating Efficacy and Safety of CRO-SBT in the Treatment of Gonorrhea
NCT06090565	PHASE4	COMPLETED	Cefixime Plus Doxycycline Compared to Ceftriaxone Plus Azithromycin for Treatment of Gonorrhoea
NCT05766904	PHASE3	ACTIVE_NOT_RECRUITING	Efficacy Trial on Meningococcal B Vaccine for Preventing Gonorrhea Infections
NCT06446752	PHASE3	ACTIVE_NOT_RECRUITING	BIYELA - Bexsero Immunisation in Young Women in Africa
NCT00120770	PHASE3	TERMINATED	Cellulose Sulfate (CS) Gel and HIV in Nigeria
NCT00124878	PHASE3	UNKNOWN	Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community
NCT00177437	PHASE3	COMPLETED	Home Screening for Chlamydia Surveillance
NCT00262106	PHASE3	COMPLETED	Trial to Evaluate PRO 2000/5 Gels for the Prevention of Vaginally Acquired HIV Infection
NCT02015637	PHASE3	TERMINATED	Comparison of Delafloxacin Versus Ceftriaxone for the Treatment of Uncomplicated Gonorrhea
NCT03294395	PHASE3	COMPLETED	New AntiBiotic Treatment Options for Uncomplicated Anogenital GOnorrhoea
NCT03867734	PHASE2/PHASE3	COMPLETED	Aztreonam for Pharyngeal Gonorrhea
NCT03959527	PHASE3	COMPLETED	Zoliflodacin in Uncomplicated Gonorrhoea
NCT04010539	PHASE3	COMPLETED	A Study Evaluating Efficacy and Safety of Gepotidacin Compared With Ceftriaxone Plus Azithromycin in the Treatment of Uncomplicated Urogenital Gonorrhea
NCT04553068	PHASE3	COMPLETED	Evaluation of EVO100 for Prevention of Urogenital Chlamydia Trachomatis and Neisseria Gonorrhoeae Infection
NCT05971550	PHASE3	UNKNOWN	Clearance of Asymptomatic Pharyngeal Carriage of Neisseria Gonorrhoeae With or Without Ceftriaxone Treatment: Randomized Non-inferiority Study
NCT00207506	PHASE1/PHASE2	COMPLETED	Lay Health Advisors for Sexually Transmitted Disease Prevention
NCT01439503	PHASE2	COMPLETED	Safer Sex Program for Young African-American Men
NCT02294682	PHASE2	COMPLETED	A Dose-Ranging Study Evaluating the Efficacy, Safety, and Tolerability of GSK2140944 in the Treatment of Uncomplicated Urogenital Gonorrhea Caused by Neisseria Gonorrhoeae
NCT03186534	PHASE2	COMPLETED	Randomized Trial of an HIV Prevention and Relationship Education Program for Young Male Couples
NCT03284541	PHASE2	COMPLETED	Online HIV Prevention for Young Male Couples
NCT04966507	PHASE2	COMPLETED	Antibacterial Mouthwash for Pharyngeal Gonorrhea Prevention
NCT05216744	PHASE2	COMPLETED	Comparison of Efficacy of Two Combination Regimens for the Neisseria Gonorrhoeae and Chlamydia Coinfection
NCT03718806	PHASE1	COMPLETED	Study to Investigate Effect of Food and Safety of a New Formulation of Zoliflodacin
NCT04484740	PHASE1	COMPLETED	Penetration of the Innovative Antibiotic Gepotidacin Into Prostate and Tonsillar Tissue
NCT05286931	Not specified	RECRUITING	SpeeDx Ciprofloxacin gyrA Assay for N. Gonorrhoeae Gonococcal Infection
NCT05326061	Not specified	RECRUITING	Vienna HIV Infection Via Sex Study
NCT05678556	Not specified	RECRUITING	Effectiveness of Relationship Education for Reducing HIV Incidence Among Men Who Have Sex With Men
NCT06428643	Not specified	RECRUITING	A Seek, Test, and Treat Intervention to Reduce Chlamydia Trachomatis Disparities
NCT06766331	Not specified	NOT_YET_RECRUITING	Integrated Care Versus Usual Care for Opioid Use Disorder and Infectious Diseases in Veterans
NCT06951438	Not specified	RECRUITING	Assessing Acceptability and Feasibiity of STI Self-swab Testing, to be Offered at the Time of Telemed Medication Abortion Provision
NCT07399873	Not specified	NOT_YET_RECRUITING	Outcomes From Point-of-Care Sexually Transmitted Infection (STI) Testing in an Urban Sexual Health Clinic: A Randomized Trial
NCT07464236	Not specified	NOT_YET_RECRUITING	Improving Clinic Delivery of HIV-related Anal Health Services
NCT07500415	Not specified	RECRUITING	Doxi-Rio: Study on the Use of Doxycycline to Prevent Sexually Transmitted Infections in Rio de Janeiro

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
CEFTRIAXONE	4	7
DOXYCYCLINE ANHYDROUS	4	3
AZITHROMYCIN	4	1
AZTREONAM	4	1
CEFIXIME	4	1
DELAFLOXACIN	4	1
ERTAPENEM	4	1
FOSFOMYCIN	4	1
GENTAMICIN	4	1
NEISSERIA MENINGITIDIS FACTOR H BINDING PROTEIN	4	1
GEPOTIDACIN	3	3
ZOLIFLODACIN	3	2
POWDERED CELLULOSE	3	1
CHEMBL3702468	0	2
CHEMBL4299381	0	1
CHEMBL195892	0	1
CHEMBL3039597	0	1
17	0	1
GENTAMICIN C1A	0	1
GENTAMICIN C2	0	1