Granular cell tumor

Summary

Granular cell tumor (MONDO:0006235) is a cancer (an umbrella term covering 9 Mondo subtypes) and 2 clinical trials. Top therapeutic interventions include calcium, cholecalciferol, and teniposide. A subtype of nerve sheath neoplasm — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Classification: Cancer
• Umbrella term: 9 Mondo subtypes
• Clinical trials: 2

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	granular cell tumor
Mondo ID	MONDO:0006235
EFO	EFO:1000284
MeSH	C535558, D016586
DOID	DOID:2411
NCIT	C3474
SNOMED CT	404035005
UMLS	C0085167
MedGen	88345
GARD	0009618
Is cancer (heuristic)	yes

Also known as: Abrikosoff’s granulous cell tumor · Abrikosoff’s granulous cell tumour · Abrikosoff’s tumor · Abrikosoff’s tumour · Abrikosov’s tumor · Abrikosov’s tumour · Abrikosov’s tumor · Abrikosov’s tumour · Abrikossoff tumor · Abrikossoff tumour · Abrikossoff’s tumor · Abrikossoff’s tumour · GCT · giant granulocellular Abrikosov’s tumor · giant granulocellular Abrikosov’s tumour · granular cell myoblastoma · granular cell neoplasm · granular cell nerve sheath tumor · granular cell nerve sheath tumour · granular cell schwannoma (+8 more)

Disease family

This is a subtype of nerve sheath neoplasm. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › nervous system disorder › peripheral nervous system disorder › peripheral nervous system neoplasm › nerve sheath neoplasm › granular cell tumor

Related subtypes (5): schwannoma, neurothekeoma, neurofibroma, malignant peripheral nerve sheath tumor, perineurioma

Subtypes (9): cutaneous granular cell tumor, breast granular cell tumor, benign granular cell tumor, esophageal granular cell tumor, granular cell cancer, vulvar granular cell tumor, mediastinal granular cell myoblastoma, neurohypophysis granular cell tumor, congenital epulis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 2.

Phase distribution (across all retrieved trials)

Phase	Trials
PHASE2	2

Top trials by phase / activity

NCT	Phase	Status	Title
NCT07188441	PHASE2	RECRUITING	Treatment of Newly Diagnosed Central Malignant Germ Cell Tumor People With Teniposide Injection Combined With Cisplatin.
NCT00396279	PHASE2	COMPLETED	Safety and Efficacy Study of Denosumab in Patients With Recurrent or Unresectable Giant Cell Tumor of Bone

Drugs tested across these trials (top 30)

Molecule	Max phase	Trials referencing
CALCIUM	4	1
CHOLECALCIFEROL	4	1
TENIPOSIDE	4	1
CHEMBL5072826	0	1