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Atlas / Disease / Granulomatous mastitis

Granulomatous mastitis

disease
On this page

Also known as granulomatous lobular mastitisidiopathic granulomatous lobular mastitisidiopathic granulomatous mastitis

Summary

Granulomatous mastitis (MONDO:0018987) is a disease and 24 clinical trials. Top therapeutic interventions include hydrocortisone butyrate, baricitinib, and esomeprazole. A subtype of female reproductive system disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

  • Prevalence: 1-9 / 100 000 (Worldwide) [Orphanet-validated]
  • Clinical trials: 24

Clinical features

Epidemiology

Prevalence records

1 prevalence record(s), Orphanet:

TypeClassValueGeographyValidation
Point prevalence1-9 / 100 0002.4WorldwideValidated

Identifiers

Disease identifiers

FieldValue
Canonical namegranulomatous mastitis
Mondo IDMONDO:0018987
MeSHD058890
Orphanet64722
ICD-10-CMN61.2
SNOMED CT237444008
UMLSC0405469
MedGen98343
GARD0018863
Is cancer (heuristic)no

Also known as: granulomatous lobular mastitis · idiopathic granulomatous lobular mastitis · idiopathic granulomatous mastitis

Disease family

This is a subtype of female reproductive system disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › reproductive system disorder › female reproductive system disorder › granulomatous mastitis

Related subtypes (33): ectopic pregnancy, pelvic inflammatory disease, endosalpingiosis, vaginal disorder, prolapse of female genital organ, Allen-Masters syndrome, fallopian tube disorder, vulvar disease, uterine disorder, gynatresia, Bartholin duct cyst, ovarian disorder, hymen, imperforate, preterm premature rupture of the membranes, mammary-digital-nail syndrome, Asherman syndrome, uterine cervical aplasia and agenesis, longitudinal vaginal septum, transverse vaginal septum, polycystic ovaries-urethral sphincter dysfunction syndrome, vaginal atresia, mullerian aplasia, vulvovaginal gingival syndrome, isolated partial vaginal agenesis, female infertility, female reproductive system neoplasm, polyp of vulva, vulval varices, vulvodynia, menstrual cycle-dependent periodic fever, Bartholin’s gland disease, delayed puberty, self-limited, menstrual disorder

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 24.

Phase distribution (across all retrieved trials)

PhaseTrials
Not specified17
PHASE43
PHASE1/PHASE22
PHASE21
PHASE11

Top trials by phase / activity

NCTPhaseStatusTitle
NCT06943482PHASE4NOT_YET_RECRUITINGComparing Effectiveness of Steroids and Methotrexate in Treatment of Chronic Inflammatory Breast Disease
NCT02959580PHASE4UNKNOWNMedical and Surgical Treatment for Idiopathic Granulomatous Mastitis
NCT03766997PHASE4UNKNOWNLocal Steroid Treatment for Idiopathic Granulomatous Mastitis (LSTIGM)
NCT05852171PHASE2ACTIVE_NOT_RECRUITINGBaricitinib in Idiopathic Granulomatous Mastitis
NCT07454772PHASE1/PHASE2NOT_YET_RECRUITINGAntibiotics vs Corticosteroids in Treatment of Granulomatous Lobular Mastitis
NCT07595900PHASE1/PHASE2NOT_YET_RECRUITINGTocilizumab for the Treatment of Refractory Granulomatous Lobular Mastitis
NCT06985537PHASE1NOT_YET_RECRUITINGSteroid Injection in Idiopathic Granulomatous Mastitis
NCT04637711Not specifiedRECRUITINGSurgical Intervention for Refractory Granulomatous Lobular Mastitis
NCT05395949Not specifiedENROLLING_BY_INVITATIONA Randomized Controlled Study of Conservative Treatment of Granulomatous Lobular Mastitis Combined With Psychiatric Disorders
NCT06565845Not specifiedRECRUITINGAnalysis of Various Treatment Methods of Granulomatous Lobular Mastitis
NCT06665399Not specifiedRECRUITINGObservation Alone for Mild Non-Lactational Mastitis
NCT06667609Not specifiedACTIVE_NOT_RECRUITINGValidity and Reliability of the Mastitis Symptom Severity Assessment Methods (M-Score and BISSI) in Non-Lactational Mastitis
NCT06712524Not specifiedRECRUITINGEffect of Different Surgical Approaches of Granulomatous Mastitis
NCT07422870Not specifiedNOT_YET_RECRUITINGGRAnulomatous MAstitis REGistry Study
NCT07512648Not specifiedNOT_YET_RECRUITINGEfficacy and Safety of Sanyong Jiedu Granules in Treating Lumps-Type Non-Lactational Mastiti
NCT03724903Not specifiedCOMPLETEDDuctal Lavage Versus Corticosteroids Therapy for Idiopathic Granulomatous Mastitis
NCT04096300Not specifiedUNKNOWNAn Integrative Approach for Idiopathic Granulomatous Mastitis.
NCT04424615Not specifiedUNKNOWNIdiopathic Granulomatous Mastitis
NCT04540237Not specifiedCOMPLETEDSerum Cytokine Values in Patients With Granulomatous Mastitis
NCT04543149Not specifiedCOMPLETEDImmune Cells in Patients With Granulomatous Mastitis
NCT04596046Not specifiedCOMPLETEDCould Intralesional Steroid be the Novel Treatment for Granulomatous Mastitis?
NCT05281419Not specifiedUNKNOWNCombined Intralesional Triamcinolone Injection With Whole Breast Detection Radical Surgery
NCT05361629Not specifiedUNKNOWNIdiopathic Granulomatous Mastitis Combination Therapy
NCT05409586Not specifiedCOMPLETEDRisk Factors and the Role of Albumin-to-globulin Ratio in Idiopathic Granulomatous Mastitis

Drugs tested across these trials (top 30)

MoleculeMax phaseTrials referencing
HYDROCORTISONE BUTYRATE42
BARICITINIB41
ESOMEPRAZOLE41
FOLIC ACID41
OMEPRAZOLE41
CHEMBL303924702
CHEMBL542785401
1701

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 20

This page pulls from 20 datasets indexed by BioBTree:

chembl_moleculecivic_evidenceclinical_trialsclinvarefogardgenccgwasgwas_studyhgncicd10cmmedgenmeshmimmondomondochildmondoparentorphanetsctidumls