group B streptococcal infection

Summary

group B streptococcal infection (MONDO:0700218) is a disease and 16 clinical trials. A subtype of streptococcal infection — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 16

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	group B streptococcal infection
Mondo ID	MONDO:0700218
NCIT	C87168
UMLS	C2020625
MedGen	378336
Is cancer (heuristic)	no

Disease family

This is a subtype of streptococcal infection. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › infectious disease › bacterial infectious disease › gram-positive bacterial infections › streptococcal infection › group B streptococcal infection

Related subtypes (7): erysipelas, streptococcal meningitis, impetigo, pneumococcal infection, scarlet fever, streptococcal toxic-shock syndrome, streptococcal sore throat

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 16.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	9
PHASE2	5
PHASE1/PHASE2	1
PHASE1	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT06611371	PHASE1/PHASE2	ACTIVE_NOT_RECRUITING	Phase I/II Study to a Assess the GBS-06 Vaccine Manufactured by Inventprise, Inc., in Healthy, Non-Pregnant, Adult Women of Childbearing Age.
NCT03170609	PHASE2	COMPLETED	A Phase 1/2, Randomized, Placebo-controlled, Observer-blinded Trial To Evaluate The Safety, Tolerability, And Immunogenicity Of A Multivalent Group B Streptococcus Vaccine In Healthy Adults 18 To 49 Years Of Age
NCT04258995	PHASE2	COMPLETED	A TRIAL TO EVALUATE THE SAFETY, TOLERABILITY, AND IMMUNOGENICITY OF A BOOSTER DOSE OF A GROUP B STREPTOCOCCUS 6 VALENT POLYSACCHARIDE CONJUGATE VACCINE (GBS6) IN HEALTHY ADULTS
NCT04596878	PHASE2	COMPLETED	Study of a Group B Streptococcus Vaccine in Pregnant Women Living With HIV and in Pregnant Women Who do Not Have HIV
NCT05154578	PHASE2	COMPLETED	Immunogenicity and Safety of GBS-NN/NN2 in Pregnant Women
NCT05832502	PHASE2	UNKNOWN	Clinical Trial Investigating the Safety and Immunogenicity of GBS6 in Pregnant Women With and Without HIV (PREPARE)
NCT05782179	PHASE1	COMPLETED	Study to Evaluate the Safety, Tolerability and Immunogenicity of Three Doses of GBS Vaccine in Elderly Participants
NCT06735703	Not specified	NOT_YET_RECRUITING	Group B Streptococcus Infection and PROM Incidince
NCT06896526	Not specified	NOT_YET_RECRUITING	Comprehensive Outcomes Monitoring for Peri- and Postnatal Invasive Group B Strep Sequelae (COMPPASS) Registry
NCT01577108	Not specified	COMPLETED	Oral Probiotics Reduce Group B Streptococci Colonization in Pregnant Women
NCT02142933	Not specified	COMPLETED	Simplified GBS Screening and Prevalence of ESBL in Pregnant Women
NCT02528981	Not specified	COMPLETED	Effect of Probiotics on GBS Colonization Status During Pregnancy: A Pilot Randomized Controlled Trial
NCT02814318	Not specified	TERMINATED	Intrapartum Effect of Vancomycin on Rectovaginal GBS Colonization
NCT04116645	Not specified	WITHDRAWN	Time Frame for GBS Screening
NCT04227730	Not specified	WITHDRAWN	MATERNAL AND NEONATAL SCREENING FOR GROUP B STREPTOCOCCI : A Follow up STUDY
NCT05726006	Not specified	UNKNOWN	Invasive Group B Streptococcus Disease Burden and Its Antimicrobial Resistance in Malaysia Among Non-pregnant Adults.