hand-Schuller-Christian disease

Summary

hand-Schuller-Christian disease (MONDO:0020519) is a disease. A subtype of Langerhans cell histiocytosis — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	hand-Schuller-Christian disease
Mondo ID	MONDO:0020519
Orphanet	99873
NCIT	C6920
SNOMED CT	39795003
UMLS	C5574737
MedGen	1804593
GARD	0006567
Is cancer (heuristic)	no

Also known as: chronic multifocal Langerhans cell histiocytosis · classic multifocal Langerhans cell histiocytosis · hand-Schuller-Christian disease · hand-SChüller-Christian disease · multifocal eosinophilic granuloma · multifocal Unisystem Langerhans cell histiocytosis

Disease family

This is a subtype of Langerhans cell histiocytosis. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › immune system disorder › lymphoid system disorder › lymphatic system disorder › histiocytosis › Langerhans cell histiocytosis › hand-Schuller-Christian disease

Related subtypes (7): Langerhans cell histiocytosis specific to childhood, Langerhans cell histiocytosis specific to adulthood, eosinophilic granuloma, unifocal langerhans cell histiocytosis, pulmonary langerhans cell histiocytosis, single-system multifocal langerhans cell histiocytosis, multisystem langerhans cell histiocytosis

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.