Head and neck paraganglioma

Summary

Head and neck paraganglioma (MONDO:0006239) is a disease and 3 clinical trials. A subtype of paraganglioma — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Clinical trials: 3

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	head and neck paraganglioma
Mondo ID	MONDO:0006239
EFO	EFO:1000288
NCIT	C5327
UMLS	C1333944
MedGen	232588
GARD	0024345
Anatomy (UBERON)	UBERON:0007811
Is cancer (heuristic)	no

Also known as: craniocervical region paraganglioma · head and neck paraganglioma · paraganglioma of craniocervical region · paraganglioma of head and neck · paraganglioma of the head and neck

Disease family

This is a subtype of paraganglioma. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by body system or component › nervous system disorder › central nervous system disorder › autonomic nervous system disorder › autonomic nervous system neoplasm › paraganglioma › head and neck paraganglioma

Related subtypes (11): pheochromocytoma/paraganglioma syndrome 4, pheochromocytoma/paraganglioma syndrome 1, pheochromocytoma/paraganglioma syndrome 2, pheochromocytoma/paraganglioma syndrome 3, pheochromocytoma/paraganglioma syndrome 5, sporadic pheochromocytoma/secreting paraganglioma, non-secreting paraganglioma, parasympathetic paraganglioma, sympathetic paraganglioma, pheochromocytoma/paraganglioma syndrome 6, pheochromocytoma/paraganglioma syndrome 7

Subtypes (4): carotid body paraganglioma, jugulotympanic paraganglioma, tympanic paraganglioma, vagus nerve paraganglioma

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 3.

Phase distribution (across all retrieved trials)

Phase	Trials
Not specified	2
PHASE4	1

Top trials by phase / activity

NCT	Phase	Status	Title
NCT01344356	PHASE4	COMPLETED	Stereotactic Body Radiotherapy for Head and Neck Tumors
NCT04583384	Not specified	UNKNOWN	In Vivo Succinate Detection After External Beam Radiation Therapy in SDHx- Paragangliomas
NCT05942482	Not specified	COMPLETED	Head and Neck Paragangliomas: A 16-year Experience of a University Hospital in Turkey