Head injury
diseaseOn this page
Summary
Head injury (MONDO:0800482) is a disease and 74 clinical trials. Top therapeutic interventions include phenytoin, albumin human, and magnesium sulfate. A subtype of injury — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- Clinical trials: 74
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | head injury |
| Mondo ID | MONDO:0800482 |
| Is cancer (heuristic) | no |
Disease family
This is a subtype of injury. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: injury › head injury
Related subtypes (9): ischemia reperfusion injury, bone fracture, acute lung injury, spinal injury, radiation injury, burn, ankle injury, nervous system injury, frostbite
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
No tiered GWAS variants or ClinVar records for this disease.
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 74.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 63 |
| PHASE3 | 3 |
| PHASE1/PHASE2 | 3 |
| PHASE2 | 2 |
| PHASE4 | 1 |
| PHASE2/PHASE3 | 1 |
| EARLY_PHASE1 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT01824589 | PHASE4 | TERMINATED | Effect of Intrathoracic Pressure Regulation on Traumatic Brain Injury |
| NCT00004730 | PHASE3 | COMPLETED | Magnesium Sulfate For Brain Injury |
| NCT00004817 | PHASE3 | COMPLETED | Phase III Double Blind Trial of Valproate Sodium for Prophylaxis of Post Traumatic Seizures |
| NCT00152685 | PHASE2/PHASE3 | UNKNOWN | High Dose Hyperoncotic Serum Albumin for the Treatment of the Acute Phase of Severe Head Injury |
| NCT00993252 | PHASE3 | COMPLETED | Canadian Computed Tomography (CT) Head Rule Study |
| NCT06073886 | PHASE2 | RECRUITING | Personalized Brain Stimulation to Treat Chronic Concussive Symptoms |
| NCT00329758 | PHASE2 | COMPLETED | Effect of Rosuvastatin on Amnesia and Orientation Through Galveston Outcome Amnesia Test in Moderate Head Injury |
| NCT00871884 | PHASE1/PHASE2 | TERMINATED | Evaluation of Two Treatments for Chronic Post Concussion Syndrome |
| NCT00990028 | PHASE1/PHASE2 | COMPLETED | Effect of Rosuvastatin on Cytokines After Traumatic Brain Injury |
| NCT01605357 | PHASE1/PHASE2 | WITHDRAWN | Hypernatremia for the Prevention and Treatment of Cerebral Edema in Traumatic Brain Injury |
| NCT06270680 | EARLY_PHASE1 | COMPLETED | Carotenoids for Collision Athletes |
| NCT04002505 | Not specified | ENROLLING_BY_INVITATION | The Concussion or Brain Bleed Trial |
| NCT05364749 | Not specified | RECRUITING | Selective CT for Anticoagulated Head Injured Patients |
| NCT05562050 | Not specified | ACTIVE_NOT_RECRUITING | Characteristics of the Anosmic Olfactory Mucosa |
| NCT05622461 | Not specified | RECRUITING | Setting Families on a Positive Path to Recovery After Pediatric TBI: Road-to-Recovery |
| NCT05663034 | Not specified | RECRUITING | CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms |
| NCT06370520 | Not specified | RECRUITING | Screening Emotions in Adolescents at the Hospital for mTBI |
| NCT06803420 | Not specified | NOT_YET_RECRUITING | AI-powered Portable MRI Abnormality Detection |
| NCT06810193 | Not specified | ENROLLING_BY_INVITATION | Monitoring & Mitigation of Neurologic Injuries to Optimize Resilience After Repetitive Head Impacts |
| NCT06932588 | Not specified | RECRUITING | Biomarker Role in Assessing Imaging Needs for Mild Cranial Trauma |
| NCT07111871 | Not specified | RECRUITING | Healthcare Services for Older People Who Have Fallen With Potential Head Injury |
| NCT07195760 | Not specified | ACTIVE_NOT_RECRUITING | Delayed IntraCranial Hemorrhage in Oral AntiCoagulant Treated Patients With Mild Traumatic Brain Injury |
| NCT00001192 | Not specified | COMPLETED | Neuropsychological Evaluation of Psychiatric and Neurological Patients |
| NCT00005004 | Not specified | COMPLETED | Brain Processing of Language Meanings |
| NCT00295074 | Not specified | COMPLETED | The Effect of Mild Traumatic Brain Injury on Recovery From Injury |
| NCT00353444 | Not specified | SUSPENDED | Transcranial Doppler Measurement and Prognosis in Moderate Head Injury |
| NCT00457600 | Not specified | COMPLETED | ParentLink: Better and Safer Emergency Care for Children |
| NCT00636376 | Not specified | COMPLETED | Effects of Head Elevation on Intracranial Pressure in Children |
| NCT00754169 | Not specified | TERMINATED | Warfighter Head Injury Study |
| NCT00886054 | Not specified | UNKNOWN | The Prediction of Intracranial Pressure and Clinical Outcome by Transcranial Doppler in Neurocritical Patients |
| NCT01054846 | Not specified | COMPLETED | Impact of Helmet Use in Preschool Children |
| NCT01113645 | Not specified | COMPLETED | Impact of Cranioplasty On Cerebral Perfusion |
| NCT01695577 | Not specified | COMPLETED | Vestibular Rehabilitation and Balance Training After Traumatic Brain Injury |
| NCT01773291 | Not specified | COMPLETED | Adjuvant Acupuncture for Severe Head Injury |
| NCT01779427 | Not specified | WITHDRAWN | Attention Intervention Management |
| NCT01824576 | Not specified | TERMINATED | Effect of Intrathoracic Pressure Regulation on Decreased Cerebral Perfusion |
| NCT01858675 | Not specified | COMPLETED | Biomarkers Correlation With Volemia |
| NCT01942564 | Not specified | COMPLETED | The Head Injury-associated Photosensitivity and Pupillary Function (HIPP) Study |
| NCT02063087 | Not specified | COMPLETED | Shared Decision Making in Parents of Children With Head Trauma: Head CT Choice |
| NCT02357186 | Not specified | COMPLETED | Broad Validation Study of a Management Algorithm Mild Head Injury in Children |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| PHENYTOIN | 4 | 2 |
| ALBUMIN HUMAN | 4 | 1 |
| MAGNESIUM SULFATE | 4 | 1 |
| VALPROATE SODIUM | 4 | 1 |
Related Atlas pages
- Drugs: Phenytoin, Albumin Human, Magnesium, Valproate