Hearing loss, mixed conductive-sensorineural
diseaseOn this page
Also known as hearing loss, mixedhearing loss, mixed conductive sensorineuralloss, mixed hearingLosses, mixed hearingmixed conductive and sensorineural deafnessmixed conductive and sensorineural hearing lossmixed hearing loss
Summary
Hearing loss, mixed conductive-sensorineural (MONDO:0044001) is a disease and 35 clinical trials. A subtype of hearing loss disorder — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- ClinVar variants: 1
- Clinical trials: 35
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | hearing loss, mixed conductive-sensorineural |
| Mondo ID | MONDO:0044001 |
| MeSH | D046089 |
| NCIT | C26974 |
| SNOMED CT | 77507001 |
| UMLS | C0155552 |
| MedGen | 102336 |
| Is cancer (heuristic) | no |
Also known as: hearing loss, mixed · hearing loss, mixed conductive sensorineural · loss, mixed hearing · Losses, mixed hearing · mixed conductive and sensorineural deafness · mixed conductive and sensorineural hearing loss · mixed hearing loss
Data availability: 1 ClinVar variant.
Disease family
This is a subtype of hearing loss disorder. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by body system or component › auditory system disorder › hearing disorder › hearing loss disorder › hearing loss, mixed conductive-sensorineural
Related subtypes (10): Johanson-Blizzard syndrome, noise induced hearing loss, nonsyndromic genetic hearing loss, sudden hearing loss disorder, sensorineural hearing loss disorder, conductive hearing loss disorder, central hearing loss, X-linked deafness, auditory neuropathy, drug-induced hearing loss
Genetics & variants
GWAS landscape
No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.
Variant details and genetic-evidence tiers
ClinVar germline variants
1 retrieved; paginated sample, class counts are floors:
1 uncertain significance
| ClinVar | Variant (HGVS) | Gene | Classification | Review |
|---|---|---|---|---|
| 267810 | 46;XX;t(4;15)(q31.3;q15) | Uncertain significance | criteria provided, single submitter |
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
No druggable-target or therapeutic data for this disease’s cohort.
Clinical trials & evidence
Clinical trials
Clinical trials: 35.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 34 |
| PHASE4 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT01264510 | PHASE4 | WITHDRAWN | Evaluation of the Effectiveness of Bone-anchored Hearing Aids (Baha) |
| NCT04899037 | Not specified | RECRUITING | Pilot Study to Evaluate the Long-term Chronic Care of Patients Who Could or do Utilize an Osseointegrated Device (OID) |
| NCT05615649 | Not specified | ACTIVE_NOT_RECRUITING | Expanded Indications in the Pediatric BONEBRIDGE Population |
| NCT06039332 | Not specified | RECRUITING | Subjective and Audiological Benefit of BONEBRIDGE (BCI602) With Two Different Fitting Strategies |
| NCT06058767 | Not specified | RECRUITING | Preschool Hearing Screening |
| NCT06976086 | Not specified | RECRUITING | Pediatric Expansion Study of the Sentio System |
| NCT07130136 | Not specified | NOT_YET_RECRUITING | Post-market Evaluation of the Transition From the Baha Connect System to the Osia System in Adult Bone Conduction Implant Recipients |
| NCT07161154 | Not specified | NOT_YET_RECRUITING | Sentio Systematic Evaluation |
| NCT07294976 | Not specified | RECRUITING | Evaluation of Actual Maximum Gain in Bone Anchored Devices |
| NCT07580287 | Not specified | NOT_YET_RECRUITING | Comparative Study of Non-surgical Hearing Devices Based on Bone Conduction |
| NCT01780025 | Not specified | COMPLETED | Objective Measures in Implantable Hearing Devices |
| NCT01796236 | Not specified | COMPLETED | Clinical and Health Economic Evaluation With a New Baha® Abutment Combined With a Minimally Invasive Surgical Technique |
| NCT02019888 | Not specified | COMPLETED | Wide Frequency Band Test of Hearing in Veterans |
| NCT02064478 | Not specified | COMPLETED | Clinical Survey of Oticon Medical Ponto Implants and a Surgical Technique With Tissue Preservation |
| NCT02274129 | Not specified | COMPLETED | Clinical Survey of Oticon Medical Healing Cap |
| NCT02304692 | Not specified | COMPLETED | Clinical Survey of Different Abutment Topologies |
| NCT03086135 | Not specified | COMPLETED | Clinical Performance of a New Implant System for Bone Conduction Hearing |
| NCT03143257 | Not specified | COMPLETED | Ambispective Clinical Evaluation of Sophono™ |
| NCT03281967 | Not specified | COMPLETED | Clinical Survey of Minimally Invasive Ponto Surgical Technique (MIPS) |
| NCT03333577 | Not specified | COMPLETED | Evaluation of the Baha SoundArc in Pediatric Patients |
| NCT03374787 | Not specified | COMPLETED | Evaluation of Sound Processor for a Transcutaneous System |
| NCT03807713 | Not specified | COMPLETED | Clinical Study of Minimally Invasive Ponto Surgical Technique (MIPS) - Design Iteration |
| NCT03848910 | Not specified | COMPLETED | Subject´s Preference Regarding Hearing Performance and Functionality Using a New Sound Processor |
| NCT03859648 | Not specified | TERMINATED | BONEBRIDGE Bone Conduction Implant in Adults |
| NCT04320407 | Not specified | COMPLETED | Osia CPT Code Study |
| NCT04427033 | Not specified | COMPLETED | The BCI 602 BONEBRIDGE Post-Market Clinical Follow-up Study |
| NCT04761926 | Not specified | COMPLETED | Investigating Hearing With the Ponto 4, a Bone Anchored Hearing Aid |
| NCT05000931 | Not specified | COMPLETED | Osia 2 Pediatric Expansion Study |
| NCT05086809 | Not specified | COMPLETED | Investigation of an Updated Bone-anchored Sound Processor |
| NCT05166265 | Not specified | UNKNOWN | Clinical Investigation Study of Safety and Performance of the Sentio System. |
| NCT05628285 | Not specified | COMPLETED | Evaluation of a Hearing Device for Transmitting Sound to the Inner Ear |
| NCT05793580 | Not specified | COMPLETED | Long Term Results With the Vibrant Soundbridge in Patients With Mixed Hearing Loss: a 60-month Longitudinal Study |
| NCT06338670 | Not specified | COMPLETED | Clinical Performance of the Osia 3 Sound Processor Compared With the Osia 2 Sound Processor in Adult Osia Implant Users |
| NCT06634784 | Not specified | COMPLETED | Evaluating the Safety of BONEBRIDGE Implants in Children Under Five Years Old: This Study Looks at Children Under Five Who Got BONEBRIDGE BCI 602 Implants. It Collects Information on Any Problems With the Device or the Surgery to See if it is Safe Within the First Year After the Operation. |
| NCT07156461 | Not specified | COMPLETED | Hearing Outcomes With the Osia 3 Sound Processor Compared to the Osia 2 Sound Processor in Adult Osia Implant Recipients |
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.