Heavy metal poisoning
diseaseOn this page
Also known as chronic heavy metal poisoningheavy metal toxicitytoxic effect of heavy metal
Summary
Heavy metal poisoning (MONDO:0023305) is a disease with 1 GWAS associations across 1 studies and 4 clinical trials. Top therapeutic interventions include edetate calcium disodium monohydrate. A subtype of poisoning — broader associated-gene and molecular evidence is on the parent page (see Disease family below).
At a glance
- GWAS associations: 1
- Clinical trials: 4
Clinical features
No curated clinical features (Orphanet) for this disease.
Identifiers
Disease identifiers
| Field | Value |
|---|---|
| Canonical name | heavy metal poisoning |
| Mondo ID | MONDO:0023305 |
| EFO | EFO:1001518 |
| MeSH | D000075322 |
| SNOMED CT | 85866007 |
| GARD | 0006577 |
| NORD | 1219 |
| Is cancer (heuristic) | no |
Also known as: chronic heavy metal poisoning · heavy metal poisoning · heavy metal toxicity · toxic effect of heavy metal
Data availability: 1 GWAS association (1 study).
Disease family
This is a subtype of poisoning. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.
Classification path: disease › human disease › disease by etiologic mechanism › disease of primarily extrinsic mechanism › poisoning › heavy metal poisoning
Related subtypes (58): toxic oil syndrome, infantile mercury poisoning, ketamine-induced biliary dilatation, manganese poisoning, cyanide-induced parkinsonism, colchicine poisoning, methanol poisoning, ethylene glycol poisoning, paraquat poisoning, lead poisoning, mercury poisoning, acute opioid poisoning, acute tricyclic antidepressant poisoning, acute poisoning by drugs with membrane-stabilizing effect, snakebite envenomation, paracetamol poisoning, cyanide poisoning, scorpion envenomation, argyria, acute ackee fruit intoxication, cocaine intoxication, systemic monochloroacetate poisoning, water intoxication, cassavism, formaldehyde poisoning, abacavir toxicity, allopurinol toxicity, codeine toxicity, efavirenz toxicity, flucloxacilline toxicity, isoniazid toxicity, raltegravir toxicity, voriconazole toxicity, curariform drugs toxicity, statin toxicity, phenytoin or carbamazepine toxicity, letrozole toxicity, ricin poisoning, ivermectin toxicity, belinostat toxicity or dose selection, toxicity to dolutegravir, mycotoxicosis, ciguatera fish poisoning, lathyrism, cadmium poisoning, phenytoin toxicity, nerve agent poisoning, local anesthetic poisoning, fire ant poisoning, aflatoxicosis, black widow spider envenomation, platinum-induced ototoxicity, carbon monoxide poisoning, organophosphate poisoning, sulfur mustard poisoning, cardiac glycoside intoxication, monochloroacetic acid poisoning, chemotherapy-induced toxicity
Subtypes (3): thallium poisoning, cesium poisoning, iron poisoning
Genetics & variants
GWAS landscape
1 GWAS associations across 1 studies. Top hits map to 1 distinct genes (as reported by GWAS).
Top associations by p-value
| rsID | p-value | Gene | Risk allele | Odds ratio |
|---|---|---|---|---|
| rs139079831 | 2e-11 | B3GAT1-DT | ? |
Top studies (by case count)
| Study | Lead author | Year | Cases | Controls | Title |
|---|---|---|---|---|---|
| GCST90651243 | Liu TY | 2025 | 93 | 236,141 | Diversity and longitudinal records: Genetic architecture of disease associations and polygenic risk in the Taiwanese Han population. |
Variant details and genetic-evidence tiers
Tier distribution (top 50 variants)
| Tier | Variants |
|---|---|
| Tier 1: coding | 0 |
| Tier 2: splice/UTR | 0 |
| Tier 3: regulatory | 0 |
| Tier 4: intronic/intergenic | 1 |
MAF distribution
| Bucket | Variants |
|---|---|
| common (>=0.05) | 0 |
| low_freq (0.01-0.05) | 0 |
| rare (<0.01) | 0 |
| unknown | 1 |
Functional consequences
| Consequence | Count |
|---|---|
| intron_variant | 1 |
Top variants
| rsID | Chr | Pos | Alleles | MAF | Consequence | Gene | p-value | Tier |
|---|---|---|---|---|---|---|---|---|
| rs139079831 | 11 | 134524977 | G>A | intron_variant | B3GAT1-DT | 2e-11 | Tier 4: intronic/intergenic |
Genes & proteins
No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).
Function
No pathway enrichment — requires an associated-gene cohort.
Therapeutics
Drugs indicated for this disease
No approved or late-stage (phase ≥3) drug is indicated for this disease; the following are in earlier-phase trials only.
Earlier-phase candidates (phase 2, investigational — efficacy not yet established): Ferrous Sulfate, Folic Acid, Propylene Glycol, Salicylic Acid, Vitamin E.
Clinical trials & evidence
Clinical trials
Clinical trials: 4.
Phase distribution (across all retrieved trials)
| Phase | Trials |
|---|---|
| Not specified | 3 |
| PHASE4 | 1 |
Top trials by phase / activity
| NCT | Phase | Status | Title |
|---|---|---|---|
| NCT02421029 | PHASE4 | WITHDRAWN | Prolonged Gadolinium Retention After MRI Imaging |
| NCT02159235 | Not specified | COMPLETED | Heavy Metals, Angiogenesis Factors and Osteopontin in Coronary Artery Disease (CAD) |
| NCT03332706 | Not specified | UNKNOWN | the Association Between Blood’s and Urinary Heavy Metal Level in Pregnant Women and the Spontaneous Abortion |
| NCT03693079 | Not specified | COMPLETED | Investigation of Wet Cupping Therapy on Heavy Metal Levels of Steel Industry Workers |
Drugs tested across these trials (top 30)
| Molecule | Max phase | Trials referencing |
|---|---|---|
| EDETATE CALCIUM DISODIUM MONOHYDRATE | 4 | 1 |