Hereditary dementia

Summary

Hereditary dementia (MONDO:0015547) is a disease (an umbrella term covering 15 Mondo subtypes). A subtype of dementia — broader associated-gene and molecular evidence is on the parent page (see Disease family below).

At a glance

• Umbrella term: 15 Mondo subtypes

Clinical features

No curated clinical features (Orphanet) for this disease.

Identifiers

Disease identifiers

Field	Value
Canonical name	hereditary dementia
Mondo ID	MONDO:0015547
Orphanet	158124
UMLS	C5680680
MedGen	1842422
GARD	0020028
Is cancer (heuristic)	no

Also known as: genetic dementia

Disease family

This is a subtype of dementia. Genetic, therapeutic, and trial evidence is largely curated at the broader-term level — see the parent page for the associated-gene cohort and molecular evidence.

Classification path: disease › human disease › disease by developmental or physiological process › psychiatric disorder › cognitive disorder › dementia › hereditary dementia

Related subtypes (8): vascular dementia, Alzheimer disease, Lewy body dementia, dementia pugilistica, parkinsonism with dementia of Guadeloupe, AIDS dementia complex, progressive dementia with neuroserpin inclusion bodies, childhood-onset dementia

Subtypes (15): neuronal intranuclear inclusion disease, hereditary sensory neuropathy-deafness-dementia syndrome, Alzheimer disease 17, Alzheimer disease 18, Huntington disease-like syndrome, frontotemporal dementia with motor neuron disease, frontotemporal dementia, neurodegeneration with brain iron accumulation, PRKAR1B-related neurodegenerative dementia with intermediate filaments, adrenoleukodystrophy, corticobasal syndrome, metachromatic leukodystrophy, posterior cortical atrophy, autosomal dominant cerebellar ataxia, familial Alzheimer disease

Genetics & variants

GWAS landscape

No GWAS associations recorded — common-variant (GWAS) studies don’t cover this disease (typical for Mendelian / rare diseases). See the curated gene cohort and Mendelian overlap below.

Variant details and genetic-evidence tiers

No tiered GWAS variants or ClinVar records for this disease.

Genes & proteins

No associated-gene cohort resolved for this disease. Atlas builds the molecular and therapeutic sections — associated genes, protein families, druggability, pathways, interactions, and drug associations — by aggregating over a disease’s associated genes (resolved via GWAS / GenCC / ClinVar / CIViC), and none resolved here. This is expected for antibody-mediated, autoimmune, or otherwise non-gene-defined conditions; the curated evidence for this disease is its clinical features, GWAS susceptibility, and clinical trials (above).

Function

No pathway enrichment — requires an associated-gene cohort.

Therapeutics

No druggable-target or therapeutic data for this disease’s cohort.

Clinical trials & evidence

Clinical trials

Clinical trials: 0.